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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 13,426–13,450 of 27,380 studies, newest first · page 538 of 1096.

December 2018 25

  1. 2018-12-07

    Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)

    Key finding: This study suggests that the baseline value of amyloid PET and CSF Aβ 42 measures may be useful for screening participants for AD trials; however, brain hippocampus atrophy and hypometabolism are only useful as repeated longitudinal assessments for tracking cognition and disease progression. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2018-12-06

    Proteomic analysis of protein homeostasis and aggregation

    ✓ Peer-reviewed Disease mechanisms Journal of proteomics

    Key finding: Various extracellular and intracellular stresses including heat shock, oxidative stress, proteasome malfunction, mutations and aging-related modifications can result in disturbed proteostasis manifested by enhanced misfolding and aggregation of proteins. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2018-12-06

    Mutation screening in Chinese patients with familial Alzheimer's disease by whole-exome sequencing

    ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

    Key finding: Two novel variants (APP: p.D244G, p.K687Q), 3 variants not previously associated with FAD (APP: p.T297M, p.D332G; PSEN1: p.R157S), and 7 previously reported pathogenic variants (APP: p.V717I; PSEN1: p.M139I, p.T147I, p.L173W, p.F177S, p.R269H; PSEN2: p.V139M) were identified. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2018-12-06

    Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

    ✓ Peer-reviewed Prevention trials Experimental gerontology

    Key finding: It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1 TG ). +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2018-12-06

    Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium

    ✓ Peer-reviewed Biomarkers Dementia and geriatric cognitive disorders

    Key finding: Our findings support an association between neuroaxonal injury and delirium. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2018-12-06

    Pet robot intervention for people with dementia: A systematic review and meta-analysis of randomized controlled trials

    ✓ Peer-reviewed Digital health tools Psychiatry research

    Key finding: The results of the meta-analysis showed a statistically significant decrease in behavioral and psychological symptoms of dementia (BPSD), especially agitation and depression, in people with dementia who were treated with PRI. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2018-12-06

    Evaluation of Technology-Based Interventions for Informal Caregivers of Patients With Dementia-A Meta-Analysis of Randomized Controlled Trials

    ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: Technology-based interventions have the potential to support informal caregivers of PWD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2018-12-05

    Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss

    ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Here, we studied Pyk2 neuronal function in mice lacking expression with and without transgenes generating amyloid-β (Aβ) plaque pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2018-12-05

    Centiloid scaling for quantification of brain amyloid with [ 18 F]flutemetamol using multiple processing methods

    ✓ Peer-reviewed Treatments EJNMMI research

    Key finding: [ 18 F]flutemetamol data can now be expressed in Centiloid units, enhancing its utility in clinical and research applications for β-amyloid imaging. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2018-12-05

    What Does Death Preparedness Mean for Family Caregivers of Persons With Dementia?

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: Most importantly attributes included (1) knowing and recognizing the symptoms of decline in dementia and what dying looks like; (2) understanding emotions and grief responses; (3) accessing and appraising supports needed to manage and care for dying; (4) organizing affairs and completing tasks in advance; (5) accepting that losses are inevitable and imminent; (6) reflecting on caregiving and finding meaning, "a silver-lining"; and (7) closing, reconciling, and renewing relationship bonds and completing the family member's life. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2018-12-05

    Disease Trajectories and End-of-Life Care for Dementias: Latent Topic Modeling and Trend Analysis Using Clinical Notes

    ✓ Peer-reviewed End-of-life care AMIA ... Annual Symposium proceedings. AMIA Symposium

    Key finding: Despite the increasing prevalence, growing costs, and high mortality of dementia in older adults in the U.S., little is known about the course of these diseases and what care dementia patients receive in their final years of life. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2018-12-05

    Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

    ✓ Peer-reviewed Genetics PLoS genetics

    Key finding: The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2018-12-04

    What enables good end of life care for people with dementia? A multi-method qualitative study with key stakeholders

    ✓ Peer-reviewed End-of-life care BMC geriatrics

    Key finding: This unique study has confirmed the relevance of much of the content of existing end of life frameworks to dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2018-12-04

    Advance Care Planning in Nursing Homes - Improving the Communication Among Patient, Family, and Staff: Results From a Cluster Randomized Controlled Trial (COSMOS)

    ✓ Peer-reviewed End-of-life care Frontiers in psychology

    Key finding: Five hundred and forty five patients from 67 NH units were included and randomized to the intervention ( N = 297; 36 units) and control group ( N = 248; 31 units). +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2018-12-03

    Effect of Liraglutide on Cardiovascular Outcomes in Elderly Patients: A Post Hoc Analysis of a Randomized Controlled Trial

    ✓ Peer-reviewed Drug development Annals of Internal Medicine

    Key finding: Buse, MD PhDDiabetes Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.B.B.), and the LEADER Publication Committee on behalf of the LEADER Trial Investigators*Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-1569 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Comorbidities and complications associated with type 2 diabetes mellitus (T2DM) increase with age, making treatment of elderly persons with this condition challenging.

    Full summary, score breakdown and related studies → Original source

  16. 2018-12-03

    The exploration of novel Alzheimer's therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches

    ✓ Peer-reviewed Drug development Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Key finding: Taken together, Cinitapride displayed a comparable results with standard and can be used as possible therapeutic agent in the treatment of AD.

    Full summary, score breakdown and related studies → Original source

  17. 2018-12-03

    Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?

    ✓ Peer-reviewed Brain scans and imaging NeuroImage. Clinical

    Key finding: Patients with PCA showed disproportionate deficits in the visuospatial domain; they also showed preserved social sensitivity and endorsed more depressive symptoms than HCs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2018-12-03

    Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology

    ✓ Peer-reviewed Disparities Acta neuropathologica

    Key finding: The earliest stages of TDP-43 pathobiology are not well-characterized, and whether neurodegeneration results from TDP-43 loss-of-function or aggregation remains unclear. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2018-12-02

    Interventions to Improve Gait in Older Adults with Cognitive Impairment: A Systematic Review

    ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society

    Key finding: Of 6,379 citations, 36 articles met inclusion criteria. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2018-12-01

    A new era for understanding amyloid structures and disease

    ✓ Peer-reviewed Risk factors Nature reviews. Molecular cell biology

    Key finding: The accumulation and deposition of amyloid fibrils, collectively known as amyloidosis, is associated with many pathological conditions that can be associated with ageing, such as Alzheimer disease, Parkinson disease, type II diabetes and dialysis-related amyloidosis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2018-12-01

    Integrated care for adults with dementia and other cognitive disorders

    ✓ Peer-reviewed End-of-life care International review of psychiatry (Abingdon, England)

    Key finding: Models of integrated community dementia assessment and management have varying degrees of involvement of primary and specialist care, but share an emphasis on improving care coordination, interdisciplinary teamwork, and personalized care. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2018-12-01

    In-hospital dementia-related deaths following implementation of the national dementia plan: observational study of national death certificates from 1996 to 2016

    ✓ Peer-reviewed Health systems and care delivery BMJ Open

    Key finding: The annual number of deaths at hospital was consistently increased over time from 1996 to 2016 (age-adjusted OR: 6.01; 95% CI 5.81 to 6.21 versus home deaths). +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2018-12-01

    Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death

    ✓ Peer-reviewed Long-term cohort studies Stroke

    Key finding: In the general population, we investigated the association of a recently developed cerebral small vessel disease (CSVD) sum score with stroke, dementia, and mortality. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2018-12-01

    CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

    ✓ Peer-reviewed TREM2 and immune genetics EMBO molecular medicine

    Key finding: We asked whether PGRN expression is changed in a disease severity-specific manner in AD We measured PGRN in cerebrospinal fluid (CSF) in two of the best-characterized AD patient cohorts, namely the Dominant Inherited Alzheimer's Disease Network (DIAN) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2018-12-01

    Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

    Key finding: This study focuses on the alterations of cerebral lactate metabolism in the double-transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mouse model of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →