Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 10,876–10,900 of 27,380 studies, newest first · page 436 of 1096.
December 2020 25
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2020-12-08
Cerebral small vessel disease genomics and its implications across the lifespan
70/100 ✓ Peer-reviewed Genetics Nature communications
Key finding: Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk.
Full summary, score breakdown and related studies → Original source
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2020-12-07
Plasma Phospho-Tau Identifies Alzheimer's Co-Pathology in Patients with Lewy Body Disease
55/100 ✓ Peer-reviewed Brain tissue and pathology Movement disorders : official journal of the Movement Disorder Society
Key finding: Plasma phospho-tau217 correlated with plasma phospho-tau181, CSF phospho-tau217 (rs = 0.68, P < 0.001), and negatively with CSF β-amyloid42/40 (rs = -0.52, P = 0.001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-12-07
Function of TREM1 and TREM2 in Liver-Related Diseases
40/100 ✓ Peer-reviewed TREM2 and immune genetics Cells
Key finding: Both TREM1 and TREM2 are immunoglobulin superfamily receptors. +3 more findings
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2020-12-06
Cognitive reserve relates to executive functioning in the old-old
41/100 ✓ Peer-reviewed Risk factors Aging clinical and experimental research
Key finding: Moderation analyses revealed a significant effect for fluency and a trend for flexibility, showing that the negative relationship between age and cognitive performance is reduced as the level of CR increases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-12-05
Development and validation of language and visuospatial composite scores in ADNI
52/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia (New York, N. Y.)
Key finding: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. +3 more findings
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2020-12-04
Repositioning of Immunomodulators: A Ray of Hope for Alzheimer's Disease?
39/100 ✓ Peer-reviewed Drug development Frontiers in neuroscience
Key finding: Current pharmacological treatments only transiently mitigate the severity of symptoms, with modest or null overall improvement.
Full summary, score breakdown and related studies → Original source
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2020-12-03
Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis
66/100 ✓ Peer-reviewed Genetics EMBO molecular medicine
Key finding: Using sparse canonical correlation analysis (sCCA), an unsupervised machine-learning technique, we observed that single nucleotide polymorphisms collectively associate with baseline cognitive performance in a large ALS patient cohort (N = 327) from the multicenter Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium. +1 more finding
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2020-12-03
Human Health and Ocean Pollution
41/100 ✓ Peer-reviewed Risk factors Annals of global health
Key finding: Bans on persistent organic pollutants (POPs) have reduced pollution by PCBs and DDT. +4 more findings
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2020-12-03
Neuroinflammation and protein pathology in Parkinson's disease dementia
48/100 ✓ Peer-reviewed Digital health tools Acta neuropathologica communications
Key finding: Digital quantification after immunohistochemical staining showed a significant increase in the severity of α-synuclein pathology in the hippocampus, entorhinal and occipitotemporal cortex of PDD compared to PDND cases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-12-02
Clinical nurse specialist's role in young-onset dementia care
39/100 ✓ Peer-reviewed Caregiving British journal of community nursing
Key finding: The CNSs address various areas affected by mid-life dementia, including patients' mental health, caregiver stress and families' psycho-social problems. +4 more findings
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2020-12-02
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease
41/100 ✓ Peer-reviewed Treatments Acta pharmacologica Sinica
Key finding: In recent decades, the concept of amyloid-β (Aβ) cascade and tau hyperphosphorylation leading to AD has dominated AD drug development. +4 more findings
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2020-12-02
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review
71/100 ✓ Peer-reviewed Mild cognitive impairment Journal of sleep research
Key finding: Psychotherapeutic approaches utilising adapted CBT-I and a Structured Limbs Exercise Programme each achieved statistically significant improvements in the Pittsburgh Sleep Quality Index with one study reporting co-existent improved actigraphy variables. +3 more findings
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2020-12-02
Occupational Noise: Auditory and Non-Auditory Consequences
46/100 ✓ Peer-reviewed Digital health tools International journal of environmental research and public health
Key finding: Occupational noise exposure accounts for approximately 16% of all disabling hearing losses, but the true value and societal costs may be grossly underestimated because current regulations only identify hearing impairments in the workplace if exposures result in audiometric threshold shifts within a limited frequency region. +2 more findings
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2020-12-01
Deep learning detection of informative features in tau PET for Alzheimer’s disease classification
57/100 ✓ Peer-reviewed Brain scans and imaging BMC Bioinformatics
Key finding: A deep learning framework combining 3D CNN and LRP algorithms can be used with tau PET images to identify informative features for AD classification and may have application for early detection during prodromal stages of AD. +3 more findings
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2020-12-01
Translating the REACH OUT dementia caregiver intervention into a primary care setting: a pilot study
41/100 ✓ Peer-reviewed Caregiving Aging & mental health
Key finding: Twenty-five caregivers participated in one of four intervention groups; 21 caregivers completed the intervention (attended at least five of six group sessions). +3 more findings
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2020-12-01
Neuropsychiatric symptoms in limbic-predominant age-related TDP-43 encephalopathy and Alzheimer's disease
66/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology
Key finding: It has been suggested that the combination of Alzheimer's disease neuropathological change (ADNC) and LATE neuropathological changes (LATE-NC) is associated with greater neuropsychiatric symptom burden, compared to either pathology alone. +3 more findings
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2020-12 month only
[Dementia of the Oldest-Old]
39/100 ✓ Peer-reviewed Brain tissue and pathology Brain and nerve = Shinkei kenkyu no shinpo
Key finding: The neuropathologic changes of dementia in the oldest-old individuals are associated with Alzheimer's disease, Lewy body disease, cerebrovascular disease, primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), and aging-related tau astrogliopathy (ARTAG).
Full summary, score breakdown and related studies → Original source
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2020-12 month only
Factors Influencing Social Isolation and Loneliness Among Lung Cancer Patients: A Cross-sectional Study
61/100 ✓ Peer-reviewed Risk factors Anticancer research
Key finding: From March 2019 to March 2020, 264 patients were included. +4 more findings
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2020-12-01
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome
48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain : a journal of neurology
Key finding: Epidemiological and experimental studies suggest that a disease-aggravating neuroinflammatory process is present at preclinical stages of Alzheimer's disease. +3 more findings
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2020-12-01
Polygala tenuifolia : a source for anti-Alzheimer's disease drugs
41/100 ✓ Peer-reviewed Drug development Pharmaceutical biology
Key finding: Polygala tenuifolia and its active components have multiplex neuroprotective potential associated with AD, such as anti-A β aggregation, anti-Tau protein, anti-inflammation, antioxidant, anti-neuronal apoptosis, enhancing central cholinergic system and promote neuronal proliferation. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-12-01
18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases
43/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Mean SUVRs were calculated for progressive supranuclear palsy, corticobasal degeneration, and neurofibrillary tangle Braak stage regions of interest, and these values were compared to SUVRs derived from young, non-autopsy, cognitively normal controls used as a standard for tau negativity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-12-01
Assessment of Plasma Amyloid-β42/40 and Cognitive Decline Among Community-Dwelling Older Adults
81/100 ✓ Peer-reviewed Biomarkers JAMA network open
Key finding: In this study, low plasma Aβ42/40 was associated with more pronounced decline in cognitive function (measured by multiple outcomes) over time. +4 more findings
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2020-12-01
Gender Inequality and Late-Life Cognition
27/100 ✓ Peer-reviewed Risk factors Innovation in Aging
Key finding: We investigate and find strong evidence that cross-state differences in gender inequality are significantly associated with the gender gap in cognition. +2 more findings
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2020-12-01
Neighborhood disadvantage is associated with accelerated cortical thinning and cognitive decline in cognitively unimpaired adults
50/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: Exposure to high neighborhood‐level socioeconomic disadvantage is associated with negative health outcomes. +4 more findings
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2020-12-01
3D Team Care Management Trial: Study Design Features and Participant Characteristics
31/100 ✓ Peer-reviewed Health systems and care delivery Innovation in Aging
Key finding: This clinical trial was designed in partnership with a Medicare Advantage (MA) plan, with the goal of comparing two care management approaches for its MA policyholders age >65 living with cognitive vulnerability. +4 more findings
Full summary, score breakdown and related studies → Original source
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