Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 10,851–10,875 of 27,380 studies, newest first · page 435 of 1096.
December 2020 25
-
2020-12-18
An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum
55/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The NTK contains promising markers that improve the pathophysiological characterization of AD.
Full summary, score breakdown and related studies → Original source
-
2020-12-18
Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study
52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of medical Internet research
Key finding: Previous studies have shown that the diagnostic performance of digital cognitive tests is comparable with that of conventional paper-and-pencil tests. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-18
Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review
53/100 ✓ Peer-reviewed Inflammation and the immune system Molecules (Basel, Switzerland)
Key finding: Alzheimer's disease (AD) is closely associated with aging and is defined by increasing memory loss and severe dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-17
Can Anti-β-amyloid Monoclonal Antibodies Work in Autosomal Dominant Alzheimer Disease?
50/100 ✓ Peer-reviewed Treatments Neurology. Genetics
Key finding: Two long-term preventive studies (Dominantly Inherited Alzheimer Network Trials Unit Adaptive Prevention Trial [DIAN-TU-APT] and Alzheimer Preventive Initiative-ADAD) were set up to evaluate the efficacy of monoclonal anti-Aβ antibodies (solanezumab, gantenerumab, and crenezumab) in carriers of ADAD, but the results of the DIAN-TU-APT study have shown that neither solanezumab nor gantenerumab slowed cognitive decline in 144 subjects with ADAD followed for 4 years, despite one of the drugs (gantenerumab) significantly affected biomarkers relevant to their intended mechanism of action. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-17
Orally Administered Benzofuran Derivative Disaggregated Aβ Plaques and Oligomers in the Brain of 5XFAD Alzheimer Transgenic Mouse
36/100 ✓ Peer-reviewed Drug development ACS chemical neuroscience
Key finding: Aβ abnormally accumulates in the brain and induces neuronal damages and symptoms of AD such as cognitive impairment and memory loss. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-16
Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
41/100 ✓ Peer-reviewed Risk factors NeuroImage. Clinical
Key finding: Compared to healthy controls, patients with FTD showed glucose hypometabolism in bilateral frontal and temporal brain areas whereas cognition was only associated with deteriorated glucose metabolism in the left temporal lobe. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-15
Fibrinogen isoforms as potential blood-based biomarkers of Alzheimer's disease using a proteomics approach
41/100 ✓ Peer-reviewed Biomarkers The International journal of neuroscience
Key finding: Mass spectrometry (MS)-based protein identification via MALDI ToF/ToF showed that fibrinogen-β-chain (spot 64) and fibrinogen-γ-chain (spot 91) with differential expression ratio >1.5 were significantly upregulated (p < 0.05) in AD patients when compared to non-AD individuals. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-15
Lessons Learnt from the Second Generation of Anti-Amyloid Monoclonal Antibodies Clinical Trials
44/100 ✓ Peer-reviewed Drug development Dementia and geriatric cognitive disorders
Key finding: Alzheimer disease (AD) is a chronic neurodegenerative disorder with complex pathophysiology that affects over 50 million people worldwide. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-14
A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region
41/100 ✓ Peer-reviewed TREM2 and immune genetics Glia
Key finding: Cell biological and biochemical analyses revealed transport of TREM2 to the cell surface, and canonical sequential proteolytic processing and shedding of TREM2 (sTREM2). +2 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-14
Deep Learning-Based Screening Test for Cognitive Impairment Using Basic Blood Test Data for Health Examination
48/100 ✓ Peer-reviewed Biomarkers Frontiers in neurology
Key finding: There were significant positive correlations between the predicted MMSE scores and ground truth scores in the Patient and Healthy groups (r = 0.66, p < 0.001). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-14
How to measure the effects and potential adverse events of palliative sedation? An integrative review
43/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: There are palliative care validated instruments to assess the sedation effect but this review shows the need for a more standardized approach when assessing it.
Full summary, score breakdown and related studies → Original source
-
2020-12-14
Exercise interventions preserve hippocampal volume: A meta-analysis
74/100 ✓ Peer-reviewed Prevention trials Hippocampus
Key finding: Exercise may be effective at increasing and preserving hippocampal volume, potentially serving as a treatment for conditions associated with hippocampal atrophy (e.g., dementia). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-14
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
57/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neurology
Key finding: According to the prevailing amyloid cascade hypothesis, amyloid-β (Aβ) deposition in the brain is the initiating event in AD, although evidence is accumulating that this hypothesis is insufficient to explain many aspects of AD pathogenesis. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-14
Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown
46/100 ✓ Peer-reviewed Digital health tools Frontiers in psychiatry
Key finding: All groups showed a worsening of cognitive (39.6%), pre-existing (37.5%), and new (26%) behavioral symptoms, and motor symptoms (35.4%) during the COVID-19 lockdown, resulting in an increased caregiver burden in 26% of cases. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-14
Added value of cerebrospinal fluid multimarker analysis in diagnosis and progression of dementia
54/100 ✓ Peer-reviewed Biomarkers European journal of neurology
Key finding: These results suggest that emerging biomarkers in conjunction with core AD markers improve diagnosis of AD, are associated with the conversion from MCI into AD, and predict a faster progression of dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-13
REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment
39/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences
Key finding: Previous findings suggested that a protein regulated in development and DNA damage response 1 (REDD1), a stress-coping regulator, is an Aβ-responsive gene involved in Aβ cytotoxicity. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-12
Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice
47/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Herein, we demonstrate that endogenous Tyrobp transcription is specifically increased in recruited microglia. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-11
Clinical Characteristics, Frailty, and Mortality of Residents With COVID-19 in Nursing Homes of a Region of Madrid
55/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: Mortality of the residents living in NHs with COVID-19 was almost 45%. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-10
Successful Discharge to Community Gap of FFS Medicare Beneficiaries With and Without ADRD Narrowed
64/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society
Key finding: Successful discharge of beneficiaries with ADRD increased from 43.4% in 2007 to 53.9% in 2015 (average annual percent change (AAPC) = 2.1 (95% CI = 2.0-2.2)); those without ADRD also increased (from 59.1% to 63.6%, AAPC = 0.9 (95% CI = 0.7-1.1)) but not as fast as those with ADRD (P < .01). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-10
Revisiting the Role of Physicians in Assisted Living and Residential Care Settings
39/100 ✓ Peer-reviewed Health systems and care delivery Gerontology & geriatric medicine
Key finding: This change increases physicians' need for information about assisted living and residential care (AL/RC) settings, which provide supportive care and housing to older adults. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-10
The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology
41/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in immunology
Key finding: During dysbiosis, these pathways are dysregulated and associated with altered permeability of the blood-brain barrier (BBB) and neuroinflammation. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2020-12-10
Current Clinical Applications of In Vivo Gene Therapy with AAVs
43/100 ✓ Peer-reviewed Brain scans and imaging Molecular therapy : the journal of the American Society of Gene Therapy
Key finding: This review is limited to gene therapy using adeno-associated virus (AAV) because the gene delivered by this vector does not integrate into the patient genome and has a low immunogenicity. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-09
Palliative and end of life care for people with advanced dementia
39/100 ✓ Peer-reviewed End-of-life care Nursing older people
Key finding: Despite growing understanding in recent years of the biological, psychological, social, environmental and spiritual aspects of dementia, people with advanced dementia continue to experience inequalities in accessing healthcare capable of improving their lives. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2020-12-08
Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging
Key finding: Ever-mounting evidence suggests that UPS deficits contribute to p-tau accumulation.
Full summary, score breakdown and related studies → Original source
-
2020-12-08
Engaging persons with dementia in advance care planning: Challenges and opportunities
47/100 ✓ Peer-reviewed End-of-life care Dementia (London, England)
Key finding: Although individually focused models of ACP engagement hold promise for those persons with dementia ready to engage in future planning, our findings suggest that early engagement of families in the reflective process may go a long way in supporting ACP activation. +1 more finding
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →