Newest studies

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

39/100 ✓ Peer-reviewed Inflammation and the immune system Nature Communications

Key finding: We found that microglia sense self-DNA from degenerating neurons following seizure, and secrete tumour necrosis factor-α, resulting in attenuation of aberrant neurogenesis. +1 more finding

• Brain Biology

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The cost of hospital-acquired complications for older people with and without dementia; a retrospective cohort study

60/100 ✓ Peer-reviewed Clinical safety BMC health services research

Key finding: Urinary tract infections, pressure areas, pneumonia and delirium are potentially preventable hospital-acquired complications. +1 more finding

• Care Services
• Policy

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Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population

43/100 ✓ Peer-reviewed Prevention trials Age (Dordrecht, Netherlands)

Key finding: Regression analysis showed that the MeDi score was not associated with LTL in the overall study population (β = 12.5; p = 0.32) after adjusting for age, sex, education, ethnicity, caloric intake, smoking, and physical and leisure activities. +4 more findings

• Lifestyle
• Health Equity

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Development of a smartphone application for the objective detection of attentional deficits in delirium

62/100 ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics

Key finding: The DelApp test showed good performance, supporting the utility of objectively measuring attention in delirium assessment. +1 more finding

• Digital Tools

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Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

48/100 ✓ Peer-reviewed Inflammation and the immune system Cell death and differentiation

Key finding: Caspase-1 (Casp1) can activate Casp6 but the expression and functionality of Casp1-activating inflammasomes has not been well-defined in human neurons. +3 more findings

• Brain Biology

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Risk of dementia in peritoneal dialysis patients compared with hemodialysis patients

67/100 ✓ Peer-reviewed Digital health tools Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Key finding: Dialysis modality is associated with incident dementia in a cohort of older ESRD patients. +3 more findings

• Risk Factors

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Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF

40/100 ✓ Peer-reviewed Disease mechanisms Oxidative medicine and cellular longevity

Key finding: The cytokine tumor necrosis factor (TNF), a master regulator of the immune system, plays an important role in the propagation of inflammation due to the activation and recruitment of immune cells via its receptor TNF receptor 1 (TNFR1). +4 more findings

• Brain Biology

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Structural Plasticity of the Hippocampus and Amygdala Induced by Electroconvulsive Therapy in Major Depression

53/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: ECT-induced neuroplasticity in the hippocampus and amygdala relates to improved clinical response and is pronounced in regions with prominent connections to ventromedial prefrontal cortex and other limbic structures. +1 more finding

• Treatments
• Brain Scans

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Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

40/100 ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

Key finding: Overexpression of apoE isoforms induces differential effects in the apoE4-TR background: apoE4 decreases apoE lipidation and enhances Aβ accumulation, whereas apoE2 has the opposite effects. +1 more finding

• Brain Biology
• Genetics

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Epidemiology of mild traumatic brain injury and neurodegenerative disease

51/100 ✓ Peer-reviewed How common it is Molecular and cellular neurosciences

Key finding: Repetitive MTBI and repetitive sub-concussive head trauma have been linked to increased risk for a variety of neurodegenerative diseases including chronic traumatic encephalopathy (CTE).

• Risk Factors
• Other Dementias

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Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)

72/100 ✓ Peer-reviewed Getting a diagnosis The Cochrane database of systematic reviews

Key finding: The Mini-Mental State Examination (MMSE) is the best-known and the most often used short screening tool for providing an overall measure of cognitive impairment in clinical, research and community settings. +3 more findings

• Diagnosis
• Early Stage

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Measurement of longitudinal β-amyloid change with 18F-florbetapir PET and standardized uptake value ratios

65/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Reference region selection has an important influence on the detection of florbetapir change. +3 more findings

• Biomarkers
• Brain Scans

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Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV‐2 Microglia

36/100 ✓ Peer-reviewed Inflammation and the immune system ChemMedChem

Key finding: The most active compound, methyl ((3 S ,10 R ,13 S )‐3‐hydroxy‐10,13‐dimethyl‐2,3,4,7,8,9,10,11,12,13,14,15,16,17‐tetradecahydro‐1 H ‐cyclopenta[ a ]phenanthrene‐17‐carbonyl)‐ L ‐phenylalaninate ( 10 ) significantly suppressed LPS‐induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase‐2 (COX‐2), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α). +2 more findings

• Brain Biology

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Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated

38/100 ✓ Peer-reviewed Vascular contributions Neuroscience letters

Key finding: The brain's ability to maintain constant blood flow across a range of cerebral perfusion pressures, or autoregulation, may both promote and result from small vessel cerebrovascular disease and AD-related amyloid pathology. +1 more finding

• Brain Scans

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Cerebral amyloid angiopathy-related atraumatic convexal subarachnoid hemorrhage: an ARIA before the tsunami

59/100 ✓ Peer-reviewed Treatments Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: Atraumatic convexal subarachnoid hemorrhage (cSAH) in elderly patients is a rare entity that has been associated with cerebral amyloid angiopathy (CAA) and intracerebral hematomas (ICH). +4 more findings

• Biomarkers
• Brain Scans

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Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease

53/100 ✓ Peer-reviewed Mild cognitive impairment Movement disorders : official journal of the Movement Disorder Society

Key finding: Baseline data of 423 PD patients and 196 HCs yielded no between-group differences in demographic characteristics. +2 more findings

• Early Stage
• Diagnosis
• Other Dementias

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GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for A lzheimer's disease

36/100 ✓ Peer-reviewed Inflammation and the immune system Glia

Key finding: In conclusion, absence of GFAP, or both GFAP and VIM, alters AD‐induced changes in gene expression profile of astrocytes, showing a compensation of the decrease of neuronal support genes and a trend for a slightly higher inflammatory expression profile.

• Brain Biology
• Biomarkers
• Genetics

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Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

38/100 ✓ Peer-reviewed Biomarkers Proceedings of the National Academy of Sciences of the United States of America

Key finding: These findings identify PSH as a surrogate protease for the screening of agents that may regulate the protease activity and the cleavage preference of γ-secretase.

• Genetics

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GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

40/100 ✓ Peer-reviewed Vascular contributions Nature neuroscience

Key finding: Alzheimer's disease is characterized by early reductions in glucose transport associated with diminished GLUT1 expression at the BBB. +1 more finding

• Brain Biology

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Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions

47/100 ✓ Peer-reviewed Inflammation and the immune system International journal of stroke : official journal of the International Stroke Society

Key finding: Potential prophylactic and treatment strategies might be those that target brain microvascular endothelium and the blood brain barrier, microvascular function and neuroinflammation. +4 more findings

• Treatments
• Other Dementias

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models

58/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine

Key finding: However, the cell types and mechanisms underlying TREM2's involvement in neurodegeneration remain to be established. +3 more findings

• Genetics
• Brain Biology

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Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

42/100 ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology

Key finding: Growing evidence indicates that the activation of c-Jun N-terminal kinase (JNK) is implicated in the multiple major pathological features of Alzheimer disease (AD). +3 more findings

• Brain Biology

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Assessment and management of behavioral and psychological symptoms of dementia

61/100 ✓ Peer-reviewed Risk factors BMJ (Clinical research ed.)

Key finding: Non-pharmacologic approaches should be used first line, although several exceptions are discussed. +4 more findings

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Levels of Processing in Working Memory: Differential Involvement of Frontotemporal Networks

36/100 ✓ Peer-reviewed Lewy body dementia Journal of Cognitive Neuroscience

Key finding: In this fMRI study, we tried to clarify the role of LTM in performance on a WM task and the type of representation that is used to maintain an item in WM during rehearsal-filled versus distractor-filled delays. +1 more finding

• Other Dementias

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Associations Between Sleep‐Disordered Breathing, Nocturnal Hypoxemia, and Subsequent Cognitive Decline in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study

66/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: Nocturnal hypoxemia was related to greater decline on the 3 MS . +4 more findings

• Lifestyle

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