Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 10,751–10,775 of 27,380 studies, newest first · page 431 of 1096.
January 2021 25
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2021 year only
Retinal Changes in Transgenic Mouse Models of Alzheimer's Disease
41/100 ✓ Peer-reviewed Brain scans and imaging Current Alzheimer research
Key finding: Accurate and early diagnosis is currently unavailable in lifespan, hampering early intervention of potential new treatments. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Donanemab (LY3002813) Phase 1b Study in Alzheimer's Disease: Rapid and Sustained Reduction of Brain Amyloid Measured by Florbetapir F18 Imaging
80/100 ✓ Peer-reviewed Brain scans and imaging The journal of prevention of Alzheimer's disease
Key finding: Treatment with donanemab resulted in rapid reduction of amyloid, even after a single dose. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD
41/100 ✓ Peer-reviewed Brain scans and imaging Current Alzheimer research
Key finding: High tau PET signal was generally observed in the lateral temporal and parietal cortices, with uptake in the occipital cortex in one subject. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk
50/100 ✓ Peer-reviewed Genetics Current Alzheimer research
Key finding: There was no difference in age acceleration between dementia cases and controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Relevance of a Truncated PRESENILIN 2 Transcript to Alzheimer's Disease and Neurodegeneration
50/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Alzheimer's disease : JAD
Key finding: PS2V levels increased in AD postmortem brain but PS2V was also present at significant levels in FTD and LBD brains. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Microglia and its Genetics in Alzheimer's Disease
41/100 ✓ Peer-reviewed Genetics Current Alzheimer research
Key finding: As the main innate immune cell type in the central nervous system (CNS), microglia play a very important role in regulating neuroinflammation, which occurs commonly in neurodegenerative conditions, including AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Interaction Between APOE Genotype and Diabetes in Longevity
59/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease : JAD
Key finding: Diabetes was associated with shorter lifespan in APOE3 carriers (n = 12,415, HR = 1.29, 95%CI = 1.17-1.42, p < 0.001) and APOE2 carriers (n = 2,390, HR = 1.37, 95%CI = 1.10-1.69, p = 0.016), while such associations were weaker and not significant in APOE4 carriers (n = 9,490, HR = 1.11, 95%CI = 0.99-1.24, p = 0.162). +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Computerized cognitive stimulation for people with dementia or with mild cognitive impairment: a bibliometric review
41/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia & neuropsychologia
Key finding: The data show that dementia research is exponentially developing following the evolution of widespread use of computer science. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Cognitive Performance and Cerebrospinal Fluid Markers in Preclinical Alzheimer's Disease: Results from the Gothenburg H70 Birth Cohort Studies
66/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD
Key finding: Among participants with CDR 0 (n = 259), those with amyloid (A+) and/or tau pathology (T+, N+) showed similar performance on most cognitive tests compared to participants with A-T-N-. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Sleep Characteristics and Cognitive Function in Older Adults Without Dementia: The CABLE Study
50/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD
Key finding: The Pittsburgh Sleep Quality Index (PSQI) total score was significantly negatively correlated with Montreal Cognitive Assessment (MoCA) score (p = 0.0176). +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Hyperconnectivity of Self-Referential Network as a Predictive Biomarker of the Progression of Alzheimer's Disease
48/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD
Key finding: Compared to cognitively normal subjects, AD-spectrum patients (i.e., EMCI, LMCI, and AD) showed a reversing trend toward an association between CSF pathological markers and the abnormal SRN occurring during the progression of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Cerebrospinal Fluid Biomarker Levels as Markers for Nursing Home Placement and Survival Time in Alzheimer's Disease
50/100 ✓ Peer-reviewed Tau biomarkers Current Alzheimer research
Key finding: After 20 years of follow-up, 123 patients (95%) were deceased. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Fluid Biomarkers of Frontotemporal Lobar Degeneration
41/100 ✓ Peer-reviewed Biomarkers Advances in experimental medicine and biology
Key finding: In recent years, significant progress has been made in developing biomarkers of neurodegenerative diseases: amyloid-β and tau in cerebrospinal fluid (CSF) can be used to exclude Alzheimer's disease, while neurofilament light chain (NfL) is emerging as a promising, albeit nonspecific, marker of neurodegeneration in both CSF and blood.
Full summary, score breakdown and related studies → Original source
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2021 year only
Inhibition of miR-96-5p May Reduce Aβ42/Aβ40 Ratio via Regulating ATP-binding cassette transporter A1
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: The expression of ABCA1 was significantly downregulated in AD models at both mRNA and protein levels. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021 year only
Plasma Neurofilament Light Chain Predicts Cognitive Progression in Prodromal and Clinical Dementia with Lewy Bodies
48/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: At baseline, plasma NfL levels were higher in both probable DLB and prodromal cases compared to controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-01-01
Visual Impairment, Eye Diseases, and Dementia Risk: A Systematic Review and Meta-Analysis
84/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: As visual impairment, cataract, and diabetic retinopathy are associated with an increased likelihood of developing dementia, early diagnosis may help identify those at risk of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-01-01
Herbal Medicines for Diabetes Management and its Secondary Complications
48/100 ✓ Peer-reviewed Risk factors Current diabetes reviews
Key finding: These constituents have shown a reduction in blood glucose levels. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-01-01
Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
77/100 ✓ Peer-reviewed Clinical trials The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Relative abundance of inflammation-causing gut bacteria was significantly reduced at Week 12 in the probiotics group (p < .05). +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-01-01
Aducanumab: Appropriate Use Recommendations
43/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease
Key finding: Aducanumab can substantially increase the incidence of amyloid-related imaging abnormalities (ARIA) with brain effusion or hemorrhage. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-01-01
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches
74/100 ✓ Peer-reviewed Genetics The Lancet. Neurology
Key finding: The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's disease and the APOE ε2 allele the strongest genetic protective factor after multiple large scale genome-wide association studies and genome-wide association meta-analyses. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-01-01
Validity of the MemTrax Memory Test Compared to the Montreal Cognitive Assessment in the Detection of Mild Cognitive Impairment and Dementia due to Alzheimer's Disease in a Chinese Cohort
43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: MemTrax can effectively detect both clinically diagnosed MCI and AD with better accuracy as compared to the MoCA based on AUCs in a Chinese cohort. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-01-01
A Brief Digital Cognitive Assessment for Detection of Cognitive Impairment in Cuban Older Adults
55/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: The BHA has excellent performance characteristics in detecting cognitive impairment including dementia and MCI in a Hispanic population in Cuba and outperformed the MoCA. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-01-01
The Computerized Cognitive Composite (C3) in an Alzheimer's Disease Secondary Prevention Trial
61/100 ✓ Peer-reviewed Cognitive tests and assessment The journal of prevention of Alzheimer's disease
Key finding: These findings provide support for both the feasibility and validity of C3 and computerized cognitive outcomes more generally in AD secondary prevention trials. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-01-01
The Impact of a Global Pandemic on People Living with Dementia and Their Care Partners: Analysis of 417 Lived Experience Reports
52/100 ✓ Peer-reviewed End-of-life care Journal of Alzheimer's disease : JAD
Key finding: Looking at the complex effects of a global pandemic through the experiences of people living with dementia and their care partners is vital to inform healthcare priorities to restore their quality of life and health and better prepare for the future. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-01-01
Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life
62/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine
Key finding: Compared with 2000, the adjusted odds ratio (AOR) for the increase in NIV use was 2.63 (95% CI, 2.46-2.82; % receipt: 0.8% vs 2.0%) for 2005 and 11.84 (95% CI, 11.11-12.61; % receipt: 0.8% vs 7.1%) for 2017. +3 more findings
Full summary, score breakdown and related studies → Original source
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