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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,501–11,525 of 27,380 studies, newest first · page 461 of 1096.

June 2020 25

  1. 2020-06-29

    Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

    ✓ Peer-reviewed TREM2 and immune genetics Nature medicine

    Key finding: We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-06-29

    Meta-analysis: Resistance Training Improves Cognition in Mild Cognitive Impairment

    ✓ Peer-reviewed Prevention and risk International Journal of Sports Medicine

    Key finding: The results indicate that general cognitive function improved significantly (standardized mean difference: 0.53, P=0.04), and further subgroup analyses on frequency and duration per session showed that the subgroups 'twice a week' (P=0.01) and 'duration per session > 60 min' (P=0.0006) exhibited better performance than the subgroups 'three time a week' (P=0.47) and 'duration per session <60 min' (P=0.53). +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2020-06-27

    The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Life sciences

    Key finding: In context, developing evidence suggest that Aβ decreases brain-derived neurotrophic factor (BDNF) mostly by lowering phosphorylated cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) protein.

    Full summary, score breakdown and related studies → Original source

  4. 2020-06-26

    Effect of long-term omega-3 supplementation and a lifestyle multidomain intervention on intrinsic capacity among community-dwelling older adults: Secondary analysis of a randomized, placebo-controlled trial (MAPT study)

    ✓ Peer-reviewed Treatments Maturitas

    Key finding: Further investigations are needed, especially trials providing stronger interventions (such as exercise training and a controlled diet) and also embracing the sensorial domain of IC.

    Full summary, score breakdown and related studies → Original source

  5. 2020-06-26

    CSF biomarkers in Olmsted County: Evidence of 2 subclasses and associations with demographics

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: We hypothesize the population without dementia can be subdivided into participants with and without biological Alzheimer disease (AD) based on the combination of CSF Aβ42 and p-tau/t-tau (represented also by the p-tau/t-tau/Aβ42 ratio). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-06-25

    Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

    ✓ Peer-reviewed Biomarkers Stem cell reports

    Key finding: Here, we report a chemical approach to rapidly generate free-floating hippocampal spheroids (HSs), from human induced pluripotent stem cells. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-06-25

    Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study

    ✓ Peer-reviewed Vascular contributions The lancet. Psychiatry

    Key finding: Broad clinical syndromes associated with COVID-19 were classified as a cerebrovascular event (defined as an acute ischaemic, haemorrhagic, or thrombotic vascular event involving the brain parenchyma or subarachnoid space), altered mental status (defined as an acute alteration in personality, behaviour, cognition, or consciousness), peripheral neurology (defined as involving nerve roots, peripheral nerves, neuromuscular junction, or muscle), or other (with free text boxes for those not meeting these syndromic presentations). +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-06-25

    Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: All synaptic biomarkers tested had a good discriminatory power to distinguish patients with AD abnormal CSF from those with non-AD disorders. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-06-24

    Effects of Cardiovascular Risk Factor Variability on Health Outcomes

    ✓ Peer-reviewed Risk factors Endocrinology and metabolism (Seoul, Korea)

    Key finding: High lipid variability is associated with increased mortality and elevated risks of cardiovascular disease, diabetes, end-stage renal disease, and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-06-24

    Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Brain, behavior, and immunity

    Key finding: Delirium is a complex and multifactorial condition associated with long-term cognitive decline. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-06-24

    Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

    ✓ Peer-reviewed TREM2 and immune genetics eLife

    Key finding: Trem2 R47H rats were engineered to produce human Aβ to define human-Aβ-dependent and -independent pathogenic mechanisms triggered by this variant. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-06-24

    Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Groups were comparable on clinical and cognitive measures. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-06-23

    Pharmacogenetic considerations when prescribing cholinesterase inhibitors for the treatment of Alzheimer's disease

    ✓ Peer-reviewed Treatments Expert opinion on drug metabolism & toxicology

    Key finding: Cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to the introduction of acetylcholinesterase inhibitors (AChEIs) in 1993 (Tacrine) to enhance cholinergic neurotransmission as the first line of treatment against Alzheimer's disease (AD).

    Full summary, score breakdown and related studies → Original source

  14. 2020-06-23

    Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases

    ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging

    Key finding: SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-06-23

    Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

    ✓ Peer-reviewed Disease mechanisms Gut

    Key finding: This population-based cohort study demonstrates significant association between IBD and subsequent development of dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2020-06-23

    Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Multiple biological pathways are altered and could be targeted very early in the Alzheimer's continuum.

    Full summary, score breakdown and related studies → Original source

  17. 2020-06-23

    The Effects of Dementia Care Co-Management on Acute Care, Hospice, and Long-Term Care Utilization

    ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

    Key finding: Comprehensive nurse practitioner dementia care co-management reduced ED visits, shortened hospital length of stay, increased hospice use, and delayed admission to long-term care. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-06-23

    The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates

    ✓ Peer-reviewed Disease mechanisms Molecular neurobiology

    Key finding: Our lab has recently shown that the Sigma-2 Receptor/Transmembrane Protein 97 (TMEM97) and Progesterone Receptor Membrane Component 1 (PGRMC1) form a complex with the Low Density Lipoprotein Receptor (LDLR), and this intact complex is required for efficient uptake of lipoproteins such as LDL and apolipoprotein E (apoE). +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-06-23

    Quality of Nursing Homes and Admission of Residents With Alzheimer's Disease and Related Dementias: The Potential Influence of Market Factors and State Policies

    ✓ Peer-reviewed Risk factors Journal of the American Medical Directors Association

    Key finding: After accounting for NH-level aggregated resident characteristics and market/state-level factors, the prevalence of ADRD among newly admitted residents was 3% lower in high-quality NHs compared with low-quality NHs (P < .01). +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-06-23

    Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity

    ✓ Peer-reviewed Down syndrome and Alzheimer's PloS one

    Key finding: In humans, GART [phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) / phosphoribosylglycinamide synthetase (EC 6.3.4.13) / phosphoribosylaminoimidazole synthetase (EC 6.3.3.1)] is a trifunctional protein which catalyzes the second, third, and fifth reactions of the ten step de novo purine synthesis (DNPS) pathway. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2020-06-23

    Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

    ✓ Peer-reviewed Caregiving Life sciences

    Key finding: Thus, disease modifying therapies which can directly address the pathological changes in AD, are needed. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-06-22

    Do Patients Retain their Family Physicians after Long-Term Care Entry? A Retrospective Cohort Study

    ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

    Key finding: Out of 50,089 LTC residents, 12.1% retained their family physicians post-LTC admission. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2020-06-22

    Optical coherence tomography in mild cognitive impairment - Systematic review and meta-analysis

    ✓ Peer-reviewed Brain scans and imaging Clinical neurology and neurosurgery

    Key finding: Thinning of retinal layers, measured using optical coherence tomography (OCT), is associated with some neurodegenerative disorders such as established Alzheimer's disease and multiple sclerosis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-06-22

    Down syndrome: A curative prospect?

    ✓ Peer-reviewed Down syndrome and Alzheimer's AIMS neuroscience

    Key finding: Experimental work regarding corrective actions on chromosomes and genes, and control of gene products is yielding promising results.

    Full summary, score breakdown and related studies → Original source

  25. 2020-06-22

    Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice

    ✓ Peer-reviewed Digital health tools The EPMA journal

    Key finding: The presented comparison was conducted on individual feature level and revealed significant differences among both cohorts. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →