Newest studies

The effects of computer-based cognitive training on attention and working memory in Thai older adults with mild cognitive impairment

32/100 ✓ Peer-reviewed Prevention trials Journal of Associated Medical Sciences

Key finding: The results showed that the experimental group had a statistically significant difference of attention (TMT-B) and working memory scores, while the control group had no statistically significant difference for both attention and working memory. +2 more findings

• Early Stage

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Herpes zoster as risk factor for dementia: a matched cohort study over 20 years in a 10-million population in Italy

51/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: We identified 132,968 individuals, of whom 12,088 with severe Zoster, 60,440 matched controls among the general population, and 60,440 matched controls among the hospitalised population. +4 more findings

• Risk Factors

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Mapping the Trajectories of Social Relations for White, Black, and Hispanic/Latino Individuals Approaching Death With Dementia

40/100 ✓ Peer-reviewed Disparities The Journals of Gerontology Series B

Key finding: Social networks shrank linearly as death approached. +4 more findings

• Health Equity

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Associations between the EAT-Lancet planetary health diet and incident dementia

49/100 ✓ Peer-reviewed Prevention and risk The Journal of Prevention of Alzheimer s Disease

Key finding: With one of the scores, higher adherence to the EAT-Lancet diet was associated with a reduced risk of AD and all-cause dementia. +4 more findings

• Risk Factors
• Lifestyle

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Invariance of Extreme Hydrologic Events and Climate Change in the Risk Reduction on Environment and Health

39/100 ✓ Peer-reviewed Prevention and risk Greenfort International Journal of Applied Medical Science

Key finding: Climate change exerts an expansive impact on global technology due to a warmer climate culminating in arduous morbidity and mortality from risks, such as extreme hydrologic events, heat, diarrhoea, malaria, emerging and reemerging infectious diseases as demonstrated on the clinicopathologic and healthcare spectra. +2 more findings

• Prevention

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APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos

64/100 ✓ Peer-reviewed Genetics Alzheimer's & Dementia

Key finding: APOE shows a heterogeneous effect on ADRD risk in our Hispanics/Latinos sample, the largest to date. +3 more findings

• Genetics

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Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis

77/100 ✓ Peer-reviewed Risk factors GeroScience

Key finding: Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, and neurodegenerative diseases such as Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID). +3 more findings

• Risk Factors
• Lifestyle

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Tau aggregation induces cell death in iPSC-derived neurons

43/100 ✓ Peer-reviewed Drug development Aging brain

Key finding: Additionally, we demonstrated the neuroprotective efficacy of known tau-targeting compounds within this system. +1 more finding

• Brain Biology
• Treatments

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Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)

43/100 ✓ Peer-reviewed Vascular contributions GeroScience

Key finding: Among the key hallmarks of aging, genomic instability and genetic heterogeneity have emerged as significant drivers of age-related diseases.

• Genetics
• Brain Biology
• Risk Factors

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Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer's disease: A DTI-ALPS study

53/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of Prevention of Alzheimer s Disease

Key finding: • Low ALPS index was significantly associated with high risk of MCI, and the risk of MCI decreased linearly with a higher ALPS index • High ALPS index was dose-dependently associated with a decreased progression from MCI to AD • High ALPS index may delay the MCI onset approximately 3.8 years among CN participants and delay MCI progression to AD by approximately 3.5 years in MCI group • Aβ in choroid plexus, tau in part of the cortex and executive function were partially mediate ALPS-AD association We aimed to explore the association between ALPS index and both risks of MCI from cognitively normal (CN) and incident AD progressed from MCI, as well as potential mediating factors.

• Early Stage

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UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia

48/100 ✓ Peer-reviewed Lewy body dementia Annals of Neurology

Key finding: UNC13A (rs12608932-CC) is associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and shortens survival in ALS. +1 more finding

• Other Dementias

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A role for astrocytic miR-129-5p in frontotemporal dementia

42/100 ✓ Peer-reviewed Lewy body dementia Translational Psychiatry

Key finding: Functional investigations in in-vitro models revealed a novel role of miR-129-5p in astrocytes, where its loss led to neuroinflammation and impaired neuronal support functions, including reduced glutamate uptake. +1 more finding

• Other Dementias
• Brain Biology

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Chronotype as a potential risk factor for cognitive decline: The mediating role of sleep quality and health behaviours in a 10-year follow-up study

54/100 ✓ Peer-reviewed Risk factors The Journal of Prevention of Alzheimer s Disease

Key finding: - Cognition was assessed with the Ruff Figural Fluency Test (RFFT), measuring non-verbal fluency and executive functioning. +4 more findings

• Risk Factors
• Lifestyle

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Association of Body Mass Index in Late Life, and Change from Midlife to Late Life, With Incident Dementia in the ARIC Study Participants

53/100 ✓ Peer-reviewed Disparities Neurology

Key finding: A total of 5,129 participants were included in the study (59% female; 22% identified as Black; mean (standard deviation) age at visit 5 of 75 (5) years). +4 more findings

• Risk Factors

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The impact of caregiver burden on sense of coherence in Chinese family caregivers of people with dementia: the mediating effect of family resilience

47/100 ✓ Peer-reviewed Caregiving BMC Psychology

Key finding: In this study, the total scores of caregiver burden, family resilience, and SOC were 45.64 ± 17.04, 175.30 ± 34.38, and 52.29 ± 15.91 among family caregivers of people with dementia. +4 more findings

• Caregiving

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A comprehensive review of climate change adaptation and disaster risk reduction in Africa

60/100 ✓ Peer-reviewed Prevention and risk Journal of Water and Climate Change

Key finding: Agriculture in Nigeria, Kenya, and Mali is impacted by droughts, necessitating resilient crops and improved irrigation. +4 more findings

• Prevention

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Long-term surveillance of the anti-amyloid monoclonal antibody lecanemab: rights and duties of pharmacovigilance

36/100 ✓ Peer-reviewed Treatments Alzheimer s Research & Therapy

Key finding: However, its regulatory assessment in Europe is still ongoing, and the European Commission has asked the Committee for Medicinal Products for Human Use of the European Medicines Agency to consider an update on the safety of lecanemab. +4 more findings

• Treatments

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A fully automated paper-based smartphone-assisted microfluidic chemiluminescence sample to result immunoassay platform

43/100 ✓ Peer-reviewed Cognitive tests and assessment Analytica chimica acta

Key finding: In this study, we developed a newly designed μPAD for CL immunoassays, leveraging smartphone-based image capture, valve-regulated reaction process, and app-driven result analysis to enable fully automated detection. +4 more findings

• Digital Tools

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Vascular Smooth Muscle Cell Dysfunction in Cerebral Small Vessel Disease: Mechanisms and Therapeutic Potential

32/100 ✓ Peer-reviewed Vascular contributions Cerebrovascular Diseases

Key finding: These dysregulations are associated with malfunctions in multiple signaling pathways or disrupted mechanical cellular responses.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cognitive therapies and their impact on neuropsychiatric symptoms in mild cognitive impairment or dementia: a scoping review

43/100 ✓ Peer-reviewed Prevention trials Frontiers in Psychology

Key finding: All participants had undergone cognitive training interventions, cognitive rehabilitation, cognitive stimulation, art therapy, reminiscence therapy or psychobehavioural therapy and were evaluated for NPS. +4 more findings

• Early Stage
• Treatments

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Natural Products in the Treatment of Neuroinflammation at Microglia: Recent Trend and Features

41/100 ✓ Peer-reviewed Inflammation and the immune system Cells

Key finding: Natural products (NPs) are considered to be the oldest medicine in human history and numerous NPs have been investigated to search for therapeutic agents in various diseases. +4 more findings

• Brain Biology
• Treatments

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Mediators of educational differences in dementia risk later in life: evidence from the HUNT study

53/100 ✓ Peer-reviewed Brain tissue and pathology BMC Public Health

Key finding: These findings suggest potential targets to address varying dementia risks linked to education levels.

• Risk Factors

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Should we Treat Sleep Apnoea to Prevent Dementia?

35/100 ✓ Peer-reviewed Risk factors Current Treatment Options in Neurology

Key finding: Obstructive sleep apnoea (OSA) is increasingly recognised as a significant risk factor for cognitive decline and dementia.

• Prevention
• Policy

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Automated Speech Analysis to Differentiate Frontal and Right Anterior Temporal Lobe Atrophy in Frontotemporal Dementia

62/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: We evaluated 62 Automated speech analysis demonstrated high accuracy in differentiating FTD subtypes and provided insights into the neural basis of language impairments. +2 more findings

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Prevalence and Misperception: Exploring the Gap Between Objective and Subjective Assessment of Sleep Apnea in a Population at Increased Risk for Dementia

49/100 ✓ Peer-reviewed How common it is Journal of Clinical Medicine

Key finding: Among 322 participants (48.8% women; mean age 71.4 ± 6.4 years), moderate-to-severe OSA (apnea–hypopnea index [AHI] ≥ 15) was identified in 48.49%, despite the absence of prior diagnoses. +4 more findings

• Risk Factors

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