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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,626–9,650 of 27,380 studies, newest first · page 386 of 1096.

November 2021 25

  1. 2021-11-07

    Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice

    ✓ Peer-reviewed Risk genes beyond APOE Behavioural brain research

    Key finding: Here, we demonstrated that the forebrain presenilin 1(Psen1)/presenilin 2 (Psen2) conditional double knockout (DKO) mice exhibited deficits in nest building, marble burying and food burrowing starting at 3 months old and worsening at later ages. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-11-06

    Racial/Ethnic Differences in Correspondence Between Subjective Cognitive Ratings and Cognitive Impairment

    ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: Blacks and Hispanics were more prone to falsely positive perceptions of their cognitive function in the presence of cognitive impairment than non-Hispanic Whites. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-11-06

    Single-cell Transcriptional Changes in Neurodegenerative Diseases

    ✓ Peer-reviewed Genetics Neuroscience

    Key finding: In recent decades, our understanding of the molecular changes involved in neurodegenerative diseases has been transformed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-11-05

    Social isolation, social support, and loneliness and their relationship with cognitive health and dementia

    ✓ Peer-reviewed Risk factors International journal of geriatric psychiatry

    Key finding: Most participants self-reported good social health (92%) with very few socially isolated (2%), with low social support (2%) or lonely (5%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-11-05

    Drug repositioning based on the heterogeneous information fusion graph convolutional network

    ✓ Peer-reviewed Drug development Briefings in bioinformatics

    Key finding: In silico reuse of old drugs (also known as drug repositioning) to treat common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked drugs, with potentially lower overall development costs and shorter development timelines.

    Full summary, score breakdown and related studies → Original source

  6. 2021-11-05

    Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults

    ✓ Peer-reviewed Biomarkers Frontiers in psychology

    Key finding: Logistic regression revealed no significant relationship between plasma total tau and any measures of neurobehavioral symptoms. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2021-11-05

    Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases

    ✓ Peer-reviewed TREM2 and immune genetics Cells

    Key finding: Gal-3's role in the central nervous system has been less studied than in the immune system. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-11-04

    Truncating tau reveals different pathophysiological actions of oligomers in single neurons

    ✓ Peer-reviewed Drug development Communications biology

    Key finding: Previously, oligomers made from full-length human tau were found to have multiple effects on neuronal properties. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-11-03

    Gut feelings: the microbiota-gut-brain axis on steroids

    ✓ Peer-reviewed Disease mechanisms American journal of physiology. Gastrointestinal and liver physiology

    Key finding: The intricate connection between central and enteric nervous systems is well established with emerging evidence linking gut microbiota function as a significant new contributor to gut-brain axis signaling.

    Full summary, score breakdown and related studies → Original source

  10. 2021-11-03

    Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation

    ✓ Peer-reviewed Risk genes beyond APOE Translational psychiatry

    Key finding: While low levels of Aβ38, Aβ40, and Aβ42 were generated in the CSF of FAD participants, the levels of Aβ43 were unchanged in some of them compared with other participants. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-11-03

    MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Science translational medicine

    Key finding: We next turned to repositories of human clinical and brain transcriptomic data, where we found that the MEF2 transcriptional network was overrepresented among genes that are most predictive of end-stage cognition. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2021-11-03

    Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Reproductive history events signaling more estrogen exposure such as premenopausal status, longer reproductive span, higher number of children, and use of HT and HC were associated with larger GMV in women in midlife. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-11-02

    Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia

    ✓ Peer-reviewed Risk factors Human brain mapping

    Key finding: Lifelong bilingualism is associated with delayed dementia onset, suggesting a protective effect on the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-11-02

    P-tau235: a novel biomarker for staging preclinical Alzheimer's disease

    ✓ Peer-reviewed Biomarkers EMBO molecular medicine

    Key finding: Combining exploratory and targeted mass spectrometry methods in neuropathologically confirmed brain tissue, we observed that p-tau235 is a prominent feature of AD pathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-11-02

    Neuropathology of Alzheimer's Disease

    ✓ Peer-reviewed Brain tissue and pathology Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    Key finding: The notion that the pathological processes underlying AD already start decades before symptoms are apparent in patients has brought a major change reflected in the current neuropathological classification of AD neuropathological changes (ADNC). +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-11 month only

    The effectiveness and value of aducanumab for Alzheimer's disease

    ✓ Peer-reviewed Costs and economics Journal of managed care & specialty pharmacy

    Key finding: DISCLOSURES: Funding for this summary was contributed by Arnold Ventures, The Donaghue Foundation, Harvard Pilgrim Health Care, and Kaiser Foundation Health Plan to the Institute for Clinical and Economic Review (ICER), an independent organization that evaluates the evidence on the value of health care interventions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-11 month only

    Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial

    ✓ Peer-reviewed Clinical trials The Lancet. Neurology

    Key finding: Between July 22, 2014, and May 17, 2018, 261 participants entered the open-label phase. 211 were randomly assigned losartan (n=105) or placebo (n=106). +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-11 month only

    Oral frailty and neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed Clinical trials Neural regeneration research

    Key finding: Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes, including falls, disability, hospitalizations, institutionalization, mortality, dementia, and Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  19. 2021-11-01

    Ophthalmic manifestations of dementing disorders

    ✓ Peer-reviewed Brain scans and imaging Current opinion in ophthalmology

    Key finding: Dementia is a term for loss of memory, language, problem-solving, and other thinking abilities, which significantly interferes with daily life.

    Full summary, score breakdown and related studies → Original source

  20. 2021-11 month only

    [Retinal Imaging as Potential Biomarkers for Dementia]

    ✓ Peer-reviewed Brain scans and imaging Brain and nerve = Shinkei kenkyu no shinpo

    Key finding: Previous studies have demonstrated that inner retinal thinning (measured using optical coherence tomography [OCT]) is associated with an increased risk of dementia, including AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2021-11-01

    Cerebrospinal fluid dynamics and discordant amyloid biomarkers

    ✓ Peer-reviewed Tau biomarkers Neurobiology of aging

    Key finding: One-hundred participants (21%) in the abnormal-CSF and/or normal-PET group had highest DESH-pattern scores and lowest CSF-phosphorylated-tau levels. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-11-01

    Low-Value Care at the Actionable Level of Individual Health Systems

    ✓ Peer-reviewed Digital health tools JAMA internal medicine

    Key finding: The findings of this large cohort study suggest that system-level measurement and reporting of specific low-value services is feasible, enables cross-system comparisons, and reveals a broad range of low-value care use. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-11-01

    Relationship between Fried's frailty phenotype and oral frailty in long-term care residents

    ✓ Peer-reviewed Digital health tools Age and ageing

    Key finding: Design the FINnish ORAL Health Study in Long-Term Care study is a cross-sectional clinical research comprising findings on oral and general health and nutrition.

    Full summary, score breakdown and related studies → Original source

  24. 2021-11-01

    Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease

    ✓ Peer-reviewed How common it is JAMA neurology

    Key finding: When identifying participants with abnormal CSF Aβ42/40 in the whole cohort, plasma IP-MS-WashU Aβ42/40 showed significantly higher accuracy (area under the receiver operating characteristic curve [AUC], 0.86; 95% CI, 0.81-0.90) than LC-MS-Arc Aβ42/40, IA-Elc Aβ42/40, IA-EI Aβ42/40, and IA-N4PE Aβ42/40 (AUC range, 0.69-0.78; P Conclusions and relevance The results from 2 independent cohorts indicate that certain MS-based methods performed better than most of the immunoassays for plasma Aβ42/40 when detecting brain Aβ pathology. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2021-11-01

    Alzheimer's disease associated with Down syndrome: a genetic form of dementia

    ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

    Key finding: Diagnosis of dementia remains a clinical challenge because of the lack of validated diagnostic criteria in this population, and because symptoms are overshadowed by the intellectual disability associated with Down syndrome.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →