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Function of TREM1 and TREM2 in Liver-Related Diseases
Sun H, Feng J, Tang L.. Cells, 2020-12-07
Topic: Brain proteins, microglia and lab models
TREM1 and TREM2 are members of the triggering receptors expressed on myeloid cells (TREM) family. Both TREM1 and TREM2 are immunoglobulin superfamily receptors. Their main function is to identify foreign antigens and toxic substances, thereby adjusting the inflammatory response.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Sun, H., Feng, J., & Tang, L. (2020). Function of TREM1 and TREM2 in Liver-Related Diseases. Cells. https://doi.org/10.3390/cells9122626
Vancouver
Sun H, Feng J, Tang L. Function of TREM1 and TREM2 in Liver-Related Diseases. Cells. 2020. doi:10.3390/cells9122626. PMID: 33297569.
BibTeX
@article{sun2020-33297569,
author = {Sun, H. and Feng, J. and Tang, L.},
title = {{Function of TREM1 and TREM2 in Liver-Related Diseases}},
journal = {Cells},
year = {2020},
doi = {10.3390/cells9122626},
pmid = {33297569},
url = {https://doi.org/10.3390/cells9122626}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Both TREM1 and TREM2 are immunoglobulin superfamily receptors.
- Their main function is to identify foreign antigens and toxic substances, thereby adjusting the inflammatory response.
- In the liver, TREM1 and TREM2 are expressed on non-parenchymal cells, such as liver sinusoidal endothelial cells, Kupffer cells, and hepatic stellate cells, and cells which infiltrate the liver in response to injury including monocyte-derived macrophages and neutrophils.
- The function of TREM1 and TREM2 in inflammatory response depends on Toll-like receptor 4.
Why it matters
This review describes the function of TREM1 and TREM2 in liver-related diseases. It is about liver disease and not Alzheimer's disease, so it has no implications for treating, curing or preventing Alzheimer's.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cells) |
| Journal's citation record | 2 / 4 | Cells: journal h-index 234 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 70 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.8 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 2 / 6 | Cited 1.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 45 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Liling Tang: h-index 40 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Chongqing University: institution h-index 493 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33297569) |
| Free to read | 2 / 2 | Free to read |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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