alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 8,376–8,400 of 27,380 studies, newest first · page 336 of 1096.

October 2022 25

  1. 2022-10-20

    Discordance and Concordance Between Cerebrospinal and [18F]FDG-PET Biomarkers in Assessing Atypical and Early-Onset AD Dementia Cases

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: We retrospectively assessed participants with atypical and/or early-onset dementia evaluated at a tertiary care memory clinic. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-10-20

    Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood of patients with diabetes based on their cognitive status

    ✓ Peer-reviewed Tau biomarkers Diabetes research and clinical practice

    Key finding: We aimed to elucidate the dynamics of blood biomarkers according to the severity of cognitive impairment in patients with type 2 diabetes mellitus (DM) and to identify useful biomarkers for diabetes-related dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-10-19

    Promoting Social Connection in Dementia Caregivers: A Call for Empirical Development of Targeted Interventions

    ✓ Peer-reviewed Risk factors The Gerontologist

    Key finding: Social connection is an understudied target of intervention for the health of individuals providing care for a family member with Alzheimer's disease and related dementias (ADRD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2022-10-19

    Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Overall, 2,277 individuals had at least 1 baseline blood biomarker available (n = 357 for CSF subsample, n = 649 for PET subsample), among whom 257 were diagnosed with clinical AD/mixed dementia during follow-up. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2022-10-18

    Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages

    ✓ Peer-reviewed TREM2 and immune genetics Biochemical and biophysical research communications

    Key finding: Furthermore, we showed that LPS-induced expression of CXC-motif chemokine ligand (Cxcl10) and Cxcl11 among the five chemokines was mediated in part through sTREM2. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2022-10-18

    Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease

    ✓ Peer-reviewed Drug development Molecular psychiatry

    Key finding: Preclinical studies have demonstrated that GLP-1 receptor agonists reduce neuroinflammation, reduce tau phosphorylation, reduce amyloid deposition, increase synaptic function, and improve memory formation.

    Full summary, score breakdown and related studies → Original source

  7. 2022-10-18

    Improving Prior Authorization in Medicare Advantage

    ✓ Peer-reviewed Health systems and care delivery JAMA

    Key finding: This Viewpoint discusses the potential benefits and harms of prior authorization in Medicare Advantage and the health policy implications and opportunities for improvement.

    Full summary, score breakdown and related studies → Original source

  8. 2022-10-18

    Feasibility and Acceptability of a Multidisciplinary Academic Telemedicine System for Memory Care in Response to COVID-19

    ✓ Peer-reviewed Risk factors Neurology Clinical Practice

    Key finding: The results of anonymous surveys conducted among the clinic9s providers are reported as descriptive findings. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2022-10-18

    Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins

    ✓ Peer-reviewed Tau biomarkers eNeuro

    Key finding: We have previously shown that the fetal brain expresses high levels of phosphorylated tau, and even tau aggregates, without apparent toxic effects. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2022-10-17

    Dietary supplements in neurological diseases and brain aging

    ✓ Peer-reviewed Prevention and risk Journal of preventive medicine and hygiene

    Key finding: The link between unhealthy diet, impaired cognitive function and neurodegenerative diseases indicates that adopting a healthy diet would ultimately afford prevention and management of neurological diseases and brain aging. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2022-10-17

    Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains

    ✓ Peer-reviewed Risk genes beyond APOE Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: We identified 133 unique and shared metabolites associated with ADAD, TREM2, and sAD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-10-17

    Potential of hsa-miR200a-3p and hsa-miR502-3p as blood-based biomarker for Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Molecular biology reports

    Key finding: Firstly, we analyzed two microarray datasets related to AD (GSE48552, GSE129053) to identify the differentially expressed miRNAs, and two miRNAs were selected for further validation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2022-10-17

    Allergic Diseases and Risk of Incident Dementia and Alzheimer's Disease

    ✓ Peer-reviewed Digital health tools Annals of neurology

    Key finding: Asthma, allergic rhinitis, and atopic dermatitis were significantly associated with increased risk of all-cause dementia and subtypes, with dose-effect relationships with the severity of allergic diseases. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2022-10-17

    Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease

    ✓ Peer-reviewed Treatments Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    Key finding: Lecanemab was distinctive as it had tenfold stronger binding to protofibrils compared to fibrils. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2022-10-17

    CSF GAP-43 as a biomarker of synaptic dysfunction is associated with tau pathology in Alzheimer's disease

    ✓ Peer-reviewed Long-term cohort studies Scientific reports

    Key finding: Associations were investigated between CSF GAP-43 and clinical diagnosis, Aβ/tau/neurodegeneration (AT(N)) status, CSF and blood biomarkers of AD, cognitive measurements and brain neuroimaging findings. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2022-10-17

    Generalizable deep learning model for early Alzheimer's disease detection from structural MRIs

    ✓ Peer-reviewed Long-term cohort studies Scientific reports

    Key finding: In this study, we have developed a new approach based on 3D deep convolutional neural networks to accurately differentiate mild Alzheimer's disease dementia from mild cognitive impairment and cognitively normal individuals using structural MRIs. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2022-10-13

    The emerging role of the microbiome in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms International review of neurobiology

    Key finding: Recent studies suggest that the intestinal microbiota is altered in AD patients when compared to healthy individuals and may play a role in disease onset and progression.

    Full summary, score breakdown and related studies → Original source

  18. 2022-10-13

    Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease

    ✓ Peer-reviewed TREM2 and immune genetics Nature communications

    Key finding: To delineate the molecular and cellular underpinnings of ICC/IDC aggressiveness, this study examines paired ICC/IDC and benign prostate surgical samples by single-cell RNA-sequencing, TCR sequencing, and histology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2022-10-13

    Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease

    ✓ Peer-reviewed Biomarkers Annals of neurology

    Key finding: In DIAD, solanezumab was not associated with ARIA. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2022-10-12

    Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period

    ✓ Peer-reviewed Prevention trials Neurology

    Key finding: The aim of this study was to investigate whether adherence to conventional dietary recommendations or to a modified Mediterranean diet are associated with a subsequent lower risk of developing all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), or with future accumulation of AD-related β-amyloid (Aβ) pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2022-10-12

    Prevalence of use and characteristics of users of home‐based medical care in Medicare Advantage

    ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

    Key finding: Overall, 1.45% of the study cohort age ≥65 received HBMC. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2022-10-12

    Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: Plasma GFAP alone differentiates AD from FTD and neurodegenerative dementias from HC but with lower accuracy than p-tau181 and NfL. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2022-10-11

    Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine

    Key finding: Genetic loss of or decreased TREM2 function impairs the microglial response to amyloid-β (Aβ) plaques, resulting in more diffuse Aβ plaques and increased peri-plaque neuritic dystrophy and AD-tau seeding. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2022-10-11

    Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

    ✓ Peer-reviewed Biomarkers Cell death & disease

    Key finding: Human genetic and animal model studies indicate that brain microglial inflammation is a primary driver of cognitive impairment in Alzheimer Disease (AD). +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2022-10-10

    Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2019

    ✓ Peer-reviewed Caregiving Frontiers in aging neuroscience

    Key finding: From 1990 to 2019, the Alzheimer's disease burden increased worldwide. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →