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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 13,376–13,400 of 27,380 studies, newest first · page 536 of 1096.

December 2018 25

  1. 2018-12-26

    The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives

    ✓ Peer-reviewed Genetics International journal of molecular sciences

    Key finding: Emerging evidence from protein binding assays suggests that APOE binds to TREM2 and APOE-containing lipoproteins in the brain as well as periphery, and are putative ligands for TREM2, thus raising the possibility of an APOE-TREM2 interaction modulating different aspects of AD pathology, potentially in an isoform-specific manner.

    Full summary, score breakdown and related studies → Original source

  2. 2018-12-24

    Interplay between Nutrition and Hearing Loss: State of Art

    ✓ Peer-reviewed Risk factors Nutrients

    Key finding: However, hearing loss receives still very limited research funding and public awareness. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2018-12-22

    The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: These findings provide additional insight into gut microbial involvement in AD and add to the growing understanding of the gut-brain axis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2018-12-21

    Hierarchical Fully Convolutional Network for Joint Atrophy Localization and Alzheimer's Disease Diagnosis Using Structural MRI

    ✓ Peer-reviewed Digital health tools IEEE transactions on pattern analysis and machine intelligence

    Key finding: Recently, a few deep learning methods (e.g., convolutional neural networks, CNNs) have been proposed to learn task-oriented features from sMRI for AD diagnosis, and achieved superior performance than the conventional learning-based methods using hand-crafted features. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2018-12-21

    Functional Re-organization of Cortical Networks of Senior Citizens After a 24-Week Traditional Dance Program

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in aging neuroscience

    Key finding: The results showed that the dance training improved optimal network performance as estimated by the small-world property. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2018-12-21

    How to improve the quality of life of elderly people with intellectual disability: A systematic literature review of support strategies

    ✓ Peer-reviewed End-of-life care Journal of applied research in intellectual disabilities : JARID

    Key finding: The studies indicated the importance of funding, provision and organization of services/personnel, education, and cooperation among different support systems.

    Full summary, score breakdown and related studies → Original source

  7. 2018-12-20

    Mediators of burden and depression in dementia family caregivers: Kinship differences

    ✓ Peer-reviewed Caregiving Dementia (London, England)

    Key finding: Perceived burden was directly and significantly related to depression for both spouse caregivers and adult child caregivers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2018-12-20

    The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors

    ✓ Peer-reviewed Disease mechanisms Cells

    Key finding: Although great efforts have been made to explore the underlying detailed mechanisms of proteostasis, there are many questions remain to explore, especially in proteostasis regulated by the ALPs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2018-12-20

    Contributions of sex to cerebrovascular function and pathology

    ✓ Peer-reviewed Vascular contributions Brain research

    Key finding: Throughout most of the lifespan, women are protected from CBVDs; however, risk increases following menopause, suggesting sex hormones may play a significant role in this protection. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2018-12-20

    Parametric methods for [18F]flortaucipir PET

    ✓ Peer-reviewed Brain scans and imaging Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: Regional binding potential (BPND) and volume of distribution (VT) values obtained from the parametric images were compared with corresponding values derived using the reversible two-tissue compartment model (2T4k_VB). +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2018-12-20

    Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

    ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

    Key finding: The distinctive seeding activity exhibited by AD and CTE tau filaments compared to other types of tauopathies in these seeded polymerization reactions provides a mechanistic basis for their consistent propagation as specific conformers in patients with 3R/4R tau diseases.

    Full summary, score breakdown and related studies → Original source

  12. 2018-12-20

    New insights into the role of TREM2 in Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: The two histopathological markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and neurofibrillary tangles of aggregated, abnormally hyperphosphorylated tau protein. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2018-12-20

    Gradual Disturbances of the Amplitude of Low-Frequency Fluctuations (ALFF) and Fractional ALFF in Alzheimer Spectrum

    ✓ Peer-reviewed Caregiving Frontiers in neuroscience

    Key finding: In the machine learning verification, the identification accuracy of SCD, aMCI, d-AD from NC was higher when fused ALFF and fALFF features (76.44, 81.94, and 91.83%, respectively) than only using ALFF or fALFF features. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2018-12-19

    A simplified radiosynthesis of [18 F]MK-6240 for tau PET imaging

    ✓ Peer-reviewed Brain scans and imaging Journal of labelled compounds & radiopharmaceuticals

    Key finding: [18 F]MK-6240 (6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective PET radiotracer for the in vivo imaging of neurofibrillary tangles (NFTs). [18 F]MK-6240 was synthesized in one step from its bis-Boc protected precursor N-[(tert-butoxy)carbonyl]-N-(6-nitro-3-[1H-pyrrolo[2,3-c]pyridin-1-yl]isoquinolin-5-yl) carbamate in DMSO using [18 F] fluoride with TEA HCO3 with step-wise heating up to 150°C, resulting in an isolated radiochemical yield of 9.8% ± 1.8% (n = 3) calculated from the end of bombardment (5.2% ± 1.0% calculated from the end of synthesis). +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2018-12-19

    Adherence to a Mediterranean Diet Protects from Cognitive Decline in the Invecchiare in Chianti Study of Aging

    ✓ Peer-reviewed Prevention trials Nutrients

    Key finding: Our findings suggest that adherence to a Mediterranean diet can have long-lasting protective effects on cognitive decline and may be an effective strategy for the prevent or delay dementia.

    Full summary, score breakdown and related studies → Original source

  16. 2018-12-19

    Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

    ✓ Peer-reviewed Brain tissue and pathology Annals of neurology

    Key finding: The degree to which Alzheimer's versus other neuropathologies contribute to the risk of Alzheimer's dementia is unknown. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2018-12-18

    Regional tau pathology and loneliness in cognitively normal older adults

    ✓ Peer-reviewed Risk factors Translational psychiatry

    Key finding: Loneliness has been associated with higher brain amyloid-β deposition, a biologic marker of Alzheimer's disease, in cognitively normal older adults, suggesting a link with preclinical Alzheimer's disease pathophysiology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2018-12-18

    Automated classification of Alzheimer's disease and mild cognitive impairment using a single MRI and deep neural networks

    ✓ Peer-reviewed Digital health tools NeuroImage. Clinical

    Key finding: High levels of accuracy were achieved in all the classifications, with the highest rates achieved in the AD vs HC classification tests using both the ADNI dataset only (99%) and the combined ADNI + non-ADNI dataset (98%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2018-12-18

    Mapping water exchange across the blood-brain barrier using 3D diffusion-prepared arterial spin labeled perfusion MRI

    ✓ Peer-reviewed Vascular contributions Magnetic resonance in medicine

    Key finding: A diffusion prepared 3D GRASE pCASL sequence with TGV regularized SPA modeling was proposed to measure BBB water permeability noninvasively with good reproducibility. k w may serve as an imaging marker of cerebral SVD and associated cognitive impairment. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2018-12-17

    Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis

    ✓ Peer-reviewed Brain scans and imaging Parkinsonism & related disorders

    Key finding: Seventeen studies with cognitively impaired Parkinson's disease patients were included consisting of 222 Parkinson's disease patients with mild cognitive impairment, 68 patients with Parkinson's disease dementia, 289 cognitively unimpaired Parkinson's disease patients and 353 healthy controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2018-12-17

    A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

    ✓ Peer-reviewed Genetics Nature neuroscience

    Key finding: Here we report that pathological tau accumulation takes place predominantly in excitatory neurons compared to inhibitory neurons, not only in the entorhinal cortex, a brain region affected in early Alzheimer's disease, but also in areas affected later by the disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2018-12-17

    Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

    ✓ Peer-reviewed Biomarkers PloS one

    Key finding: We show that mini-brains obtained from a non-AD control cell line are responsive to chemical compound induction, producing a shift of physiological Aβ concentrations, suggesting that this model can be used to identify environmental agents that may initiate the cascade of events ultimately leading to sporadic AD.

    Full summary, score breakdown and related studies → Original source

  23. 2018-12-17

    Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life

    ✓ Peer-reviewed Cognitive tests and assessment The Cochrane database of systematic reviews

    Key finding: Vitamins and minerals play multiple functions within the central nervous system which may help to maintain brain health and optimal cognitive functioning. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2018-12-17

    Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2018-12-14

    Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in neuroscience

    Key finding: Alzheimer's disease (AD) is the most common neurodegenerative disorder, which is clinically associated with a global cognitive decline and progressive loss of memory and reasoning.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →