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Development and validation of language and visuospatial composite scores in ADNI
Choi SE, Mukherjee S, Gibbons LE, Sanders RE, Jones RN, Tommet D, Mez J, Trittschuh EH et al.. Alzheimer's & dementia (New York, N. Y.), 2020-12-05
Topic: Risk, prevention and care in population studies
Introduction Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress.
Key findings
- Methods We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
- We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress.
- Results ADNI-Lan and ADNI-VS were able to detect change over time and predict conversion from MCI to AD.
- They were associated with most of the pre-specified magnetic resonance imaging measures.
Why it matters
This work developed and validated language and visuospatial composite scores using cognitive data from ADNI. It concerns measurement tools for research and assessment, not treating, curing or preventing Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (New York, N. Y.)) |
| Journal's citation record | 1 / 4 | Alzheimer s & Dementia Translational Research & Clinical Interventions: journal h-index 84 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 83 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.4 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 5.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 50 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Paul K. Crane: h-index 101 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33313380) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/trc2.12072
- PubMed: 33313380
- Original source →
- Free full text: Alzheimer s & Dementia Translational Research & Clinical Interventions →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Choi, S. E., Mukherjee, S., Gibbons, L. E., Sanders, R. E., Jones, R. N., Tommet, D., et al. (2020). Development and validation of language and visuospatial composite scores in ADNI. Alzheimer's & dementia (New York, N. Y.). https://doi.org/10.1002/trc2.12072
Vancouver
Choi SE, Mukherjee S, Gibbons LE, Sanders RE, Jones RN, Tommet D, et al. Development and validation of language and visuospatial composite scores in ADNI. Alzheimer's & dementia (New York, N. Y.). 2020. doi:10.1002/trc2.12072. PMID: 33313380.
BibTeX
@article{choi2020-33313380,
author = {Choi, S. E. and Mukherjee, S. and Gibbons, L. E. and Sanders, R. E. and Jones, R. N. and Tommet, D. and Mez, J. and Trittschuh, E. H. and others},
title = {{Development and validation of language and visuospatial composite scores in ADNI}},
journal = {Alzheimer's \& dementia (New York, N. Y.)},
year = {2020},
doi = {10.1002/trc2.12072},
pmid = {33313380},
url = {https://doi.org/10.1002/trc2.12072}
}
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