Newest studies

Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity

60/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: These results suggest that plasma biomarkers can augment detection of preclinical AD among asymptomatic individuals and improve the specificity of AD diagnosis.

• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues

41/100 ✓ Peer-reviewed Risk factors Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: Factors such as insulin resistance, hyperglycemia, high blood pressure, dyslipidemia, and central obesity in metabolic syndrome are associated with synaptic failure, neuroinflammation, and imbalanced neurotransmitter levels, leading to the progression of dementia. +1 more finding

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

55/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research. +2 more findings

• Digital Tools
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Trends in Alzheimer Disease Mortality Among American Indian and Alaska Native People Between 2011 and 2019

35/100 ✓ Peer-reviewed Risk factors Alzheimer Disease & Associated Disorders

Key finding: AD mortality rates significantly increased over time. +4 more findings

Full summary, score breakdown and related studies → Original source

Editor's view

54/100 ✓ Peer-reviewed Health systems and care delivery Age and Ageing

Key finding: In-hospital death among nursing home residents with dementia has been associated with poorer quality of end-of-life care. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Association of Cardiovascular Health With Life Expectancy Free of Cardiovascular Disease, Diabetes, Cancer, and Dementia in UK Adults

72/100 ✓ Peer-reviewed Long-term cohort studies JAMA internal medicine

Key finding: The average life expectancy has increased substantially in the past few decades in most industrialized countries; however, not all of the increased life expectancy is being spent in optimal health, especially among individuals with low socioeconomic status. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

The future of alzheimer disease immunotherapies in Saudi Arabia: Consensus statement of the Saudi Chapter of Cognitive and Behavioral Neurology

36/100 ✓ Peer-reviewed Drug development Neurosciences (Riyadh, Saudi Arabia)

Key finding: Standard AD pharmacotherapies offer only modest transient cognitive and behavioral benefits. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Alzheimer's disease drug development pipeline: 2023

53/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia (New York, N. Y.)

Key finding: The AD drug development pipeline is advancing agents directed at a variety of target processes.

• Treatments
• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease

72/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: We found that the mass spectrometry-based p-tau217 (p-tau217WashU) exhibited significantly better performance than all other plasma p-tau biomarkers when detecting abnormal Aβ status [area under curve (AUC) = 0.947; Pdiff < 0.015] or progression to Alzheimer's dementia (AUC = 0.932; Pdiff < 0.027). +4 more findings

• Diagnosis
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest

72/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: In this case-control study, blood biomarkers indicative of AD pathology demonstrated different dynamics of change after cardiac arrest. +4 more findings

• Biomarkers
• Care Services

Full summary, score breakdown and related studies → Original source

Plasma Glial Fibrillary Acidic Protein in the Alzheimer Disease Continuum: Relationship to Other Biomarkers, Differential Diagnosis, and Prediction of Clinical Progression

53/100 ✓ Peer-reviewed Biomarkers Clinical chemistry

Key finding: Plasma GFAP effectively distinguished AD dementia from multiple neurodegenerative diseases, gradually increased across the AD continuum, predicted the individual risk of AD progression, and strongly correlated with AD CSF/neuroimaging biomarkers. +1 more finding

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers

79/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Among 171 Aβ-positive CU participants included in the main analyses, 119 (mean [SD] age, 73.0 [5.4] years; 60.5% female) were from the BioFINDER-1 study, and 52 (mean [SD] age, 64.4 [4.6] years; 65.4% female) were from the WRAP study. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Interim Phase 1 multiple ascending dose results for remternetug (LY3372993) in Alzheimer's disease

16/100 ⚠ Conference abstract — not peer-reviewed Clinical trials Presented at AD/PD 2023 Conference (Gothenburg, Sweden); covered by ALZFORUM and NeurologyLive

Key finding: 41 participants total across placebo and 250-2,800 mg dose groups +4 more findings

• Clinical Trials
• Treatments

Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Residential greenness, air pollution and incident neurodegenerative disease: A cohort study in China

71/100 ✓ Peer-reviewed Risk factors The Science of the total environment

Key finding: During the follow-up period, we identified a total of 617 incident neurodegenerative diseases, 301 PD and 182 AD. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Supervised, Self-Administered Tablet-Based Cognitive Assessment in Neurodegenerative Disorders and Stroke

75/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders

Key finding: Statistically significant Pearson correlations between the neuropsychological tests and their tablet equivalents were found for all domains with moderate (r > 0.3) or strong (r > 0.7) correlations in 16 of 17 tests (p < 0.05). +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Patient Characteristics Associated With Being Offered or Choosing Telephone vs Video Virtual Visits Among Medicare Beneficiaries

55/100 ✓ Peer-reviewed Health systems and care delivery JAMA network open

Key finding: To evaluate characteristics of Medicare beneficiaries associated with practices and clinicians offering telephone visits only and patients receiving telephone visits only, when both telephone and video were available. +4 more findings

• Policy
• Health Equity

Full summary, score breakdown and related studies → Original source

TREM2 Insufficiency Protects against Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization

43/100 ✓ Peer-reviewed TREM2 and immune genetics International immunopharmacology

Key finding: Idiopathic pulmonary fibrosis (IPF) is a lung disease with high mortality, limited treatment options and an unknown aetiology. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Sex and gender considerations in Alzheimer's disease: The Women's Brain Project contribution

46/100 ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

Key finding: As a result, new approaches to dementia diagnosis, care, and patient journeys should be considered.

Full summary, score breakdown and related studies → Original source

Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review

53/100 ✓ Peer-reviewed Getting a diagnosis International journal of molecular sciences

Key finding: Numerous mediators secreted by inflammatory cells can cause neuronal degeneration. +4 more findings

• Diagnosis
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Ability and Willingness to Participate in Dementia Clinical Research: A Qualitative Study

48/100 ✓ Peer-reviewed Caregiving The patient

Key finding: Ten themes were organized into two categories. +3 more findings

Full summary, score breakdown and related studies → Original source

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

43/100 ✓ Peer-reviewed Inflammation and the immune system Science translational medicine

Key finding: Analysis of human cerebrospinal fluid (CSF) samples from a genetic FTD cohort revealed reduced concentrations of Nptx2 and Nptx2-C1q protein complexes in symptomatic patients, which correlated with elevated C1q and activated C3. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Deep learning-based EEG analysis to classify normal, mild cognitive impairment, and dementia: Algorithms and dataset

48/100 ✓ Peer-reviewed Digital health tools NeuroImage

Key finding: Extensive experiments showed that our CEEDNet significantly improves the accuracy compared with existing methods, such as machine learning methods and Ieracitano-CNN (Ieracitano et al., 2019), due to taking full advantage of end-to-end learning.

• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment

70/100 ✓ Peer-reviewed Disease mechanisms Geriatric nursing (New York, N.Y.)

Key finding: After 12 weeks of intervention, cognitive function and sleep quality were improved in the probiotic group compared with those in the control group, and the underlying mechanisms were associated with changes in the intestinal microbiota. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly

41/100 ✓ Peer-reviewed Risk factors Annual review of neuroscience

Key finding: In mouse models of the disease, circadian disturbances accelerate astroglial activation and other brain pathologies, suggesting that daily functions in astrocytes protect neuronal homeostasis. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

APOE and immunity: Research highlights

45/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source