Newest studies

Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity

51/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Correlations were overall high in healthy controls (ρ = 0.80 ± 0.04), but showed a significant 17% reduction (p < 0.05) in aMCI/AD patients (ρ = 0.67 ± 0.05). +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology

53/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: CSF Ng was specifically increased in ADD compared to eight other neurodegenerative diseases, including Parkinson's disease (p < 0.0001), frontotemporal dementia (p < 0.0001), and amyotrophic lateral sclerosis (p = 0.0002). +4 more findings

• Brain Biology
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies

44/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Glial fibrillary acidic protein (GFAP) mRNA expression is significantly increased in AD but not in DLB, whereas GLT1 , vesicular glutamate transporter 1 ( vGLUT1 ) and aldehyde dehydrogenase 1 family member 1 ( ALDH1L1 ) are not modified in AD and DLB when compared with controls. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008-2016

70/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Dementia diagnosis recording in general hospitals is increasing but remains less likely in some groups.

• Health Equity
• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Anticholinergic drugs and risk of dementia: case-control study

71/100 ✓ Peer-reviewed Getting a diagnosis BMJ (Clinical research ed.)

Key finding: A robust association between some classes of anticholinergic drugs and future dementia incidence was observed. +2 more findings

• Risk Factors
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

ABBY: A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease

74/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Although prespecified criteria for testing treatment effects were not met, these data suggest a potential treatment effect in patients with mild AD treated with high-dose crenezumab. +3 more findings

• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

[Late life depression - Diagnosis, pathophysiology and therapeutic strategies]

39/100 ✓ Peer-reviewed Risk factors Fortschritte der Neurologie-Psychiatrie

Key finding: LLD is associated with various adverse outcomes, such as reduced quality of life, negative impact on physical comorbidities, functional impairments, increased suicide and non-suicide mortality.

• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cognitive function trajectories and their determinants in older people: 8 years of follow-up in the English Longitudinal Study of Ageing

69/100 ✓ Peer-reviewed Risk factors Journal of epidemiology and community health

Key finding: The potential determinants of cognitive decline identified in this study, in particular modifiable risk factors, should be tested in the context of randomised controlled trials. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Subthreshold Amyloid Predicts Tau Deposition in Aging

60/100 ✓ Peer-reviewed Treatments The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: We found evidence for an inverted-U relationship between baseline Aβ levels and Aβ slope in asymptomatic older adults, suggesting a slowing of Aβ accumulation even in cognitively normal adults. +4 more findings

Full summary, score breakdown and related studies → Original source

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

41/100 ✓ Peer-reviewed Treatments Scientific reports

Key finding: In silico analyses suggest that aducanumab interacts weakly with the Aβ monomer and may accommodate a variety of peptide conformations, further supporting its selectivity for Aβ aggregates.

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Risk factors for non-motor symptoms in Parkinson's disease

62/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

Key finding: However, current understanding of NMS is incomplete, particularly as a result of the absence of standardisation of outcome definitions and the heterogeneity of the risk factors that are assessed. +1 more finding

• Risk Factors
• Prevention
• Treatments

Full summary, score breakdown and related studies → Original source

A Web-Based Intervention to Help Caregivers of Older Adults With Dementia and Multiple Chronic Conditions: Qualitative Study

56/100 ✓ Peer-reviewed Treatments JMIR aging

Key finding: Recent evidence suggests that Web-based interventions have the potential to support caregivers by decreasing caregiver stress and burden. +2 more findings

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Stress as risk factor for Alzheimer's disease

38/100 ✓ Peer-reviewed Disease mechanisms Pharmacological research

Key finding: Preclinical studies have suggested that manipulation of the glucocorticoid milieu can trigger cellular, molecular and behavioral derangement resembling the hallmarks of Alzheimer's Disease (AD). +1 more finding

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

The experiences and preparedness of family carers for best interest decision-making of a relative living with advanced dementia: A qualitative study

64/100 ✓ Peer-reviewed End-of-life care Journal of advanced nursing

Key finding: The experiences and preparedness of informal carers is a reflection of their personal response, but the distress experienced highlights the significant need of adequate support availability and of enhancing nursing staffs' dementia expertise to maximize their role in facilitating best interest decision-making. +3 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Atrophy patterns in cerebral amyloid angiopathy with and without cortical superficial siderosis

46/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Our findings imply that the current version of the Boston criteria may not be sufficient enough to remove non-CAA cases from a cognitively impaired population, especially in the absence of cSS. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Chronic Stress, Social Isolation, and Perceived Loneliness in Dementia Caregivers

39/100 ✓ Peer-reviewed Risk factors Journal of psychosocial nursing and mental health services

Key finding: These exogenous factors may lead to perceived stress and perceived loneliness-psychosocial endogenous (subjective) elements of caregiving experience. +4 more findings

• Lifestyle
• Caregiving

Full summary, score breakdown and related studies → Original source

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP NL-F/NL-F knock-in mice

41/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: Female APP NL/NL knock-in mice of 3 and 7 months old were compared to age-matched APP NL-F/NL-F mice with increased Aβ42/40 ratio and initial Aβ-plaque deposition around 6 months of age. +1 more finding

• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content

49/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We believe this to be the first demonstration of myelin loss in MCI, Alzheimer's disease, and vascular dementia using a method that provides a quantitative magnetic resonance imaging-based measure of myelin. +1 more finding

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Connected speech and language in mild cognitive impairment and Alzheimer's disease: A review of picture description tasks

53/100 ✓ Peer-reviewed Digital health tools Journal of clinical and experimental neuropsychology

Key finding: Our review shows that picture description tasks are useful tools for detecting differences in a wide variety of language and communicative measures. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

What does the general public understand about prevention and treatment of dementia? A systematic review of population-based surveys

60/100 ✓ Peer-reviewed Prevention and risk PloS one

Key finding: Knowledge among those living in low- and middle-income countries are largely unknown, presenting challenges for the development of National action plans consistent with World Health Organization directives. +3 more findings

• Prevention
• Treatments

Full summary, score breakdown and related studies → Original source

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice

39/100 ✓ Peer-reviewed Genetics Neuroscience

Key finding: The ApoE ε4 allele (ApoE4) is the single most important genetic risk-factor for Alzheimer's disease (AD) while the ε2 allele (ApoE2) is associated with a lower risk of AD-related neurodegeneration compared to the most common variant, ε3 (ApoE3). +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mechanism of NMDA receptor channel block by MK-801 and memantine

43/100 ✓ Peer-reviewed Treatments Nature

Key finding: The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice

41/100 ✓ Peer-reviewed Biomarkers Journal of neuroinflammation

Key finding: These findings indicate that galantamine could be a promising treatment to improve endotoxin-induced cognitive decline and neuroinflammation in neurodegenerative diseases. +2 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Mild TBI and risk of Parkinson disease: A Chronic Effects of Neurotrauma Consortium Study

71/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Among military veterans, mTBI is associated with 56% increased risk of PD, even after adjusting for demographics and medical/psychiatric comorbidities. +3 more findings

• Prevention
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Inflammation in CNS neurodegenerative diseases

38/100 ✓ Peer-reviewed Inflammation and the immune system Immunology

Key finding: Despite the different aetiologies, for example, infections, genetic mutations, trauma and protein aggregations, neuronal damage is frequently associated with chronic activation of an innate immune response in the CNS.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source