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72/100

✓ Peer-reviewed alzhub usefulness score 72 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Results This study included 717 participants (137 [19.1%] female and 580 male [80.9%]; mean [SD] age, 63.9 [13.5] years) who experienced out-of-hospital cardiac arrest. Significantly elevated serum p-tau levels were observed at 24 hours, 48 hours, and 72 hours in cardiac arrest patients with poor neurological outcome. However, at later time points, p-tau levels decreased and were weakly associated with neurological outcome. Serum Aβ42 and Aβ40 concentrations increased over time in most patients but were only weakly associated with neurological outcome. Conclusions and relevance In this case-control study, blood biomarkers indicative of AD pathology demonstrated different dynamics of change after cardiac arrest.

Key findings

Results This study included 717 participants (137 [19.1%] female and 580 male [80.9%]; mean [SD] age, 63.9 [13.5] years) who experienced out-of-hospital cardiac arrest.
Significantly elevated serum p-tau levels were observed at 24 hours, 48 hours, and 72 hours in cardiac arrest patients with poor neurological outcome.
However, at later time points, p-tau levels decreased and were weakly associated with neurological outcome.
Serum Aβ42 and Aβ40 concentrations increased over time in most patients but were only weakly associated with neurological outcome.
Conclusions and relevance In this case-control study, blood biomarkers indicative of AD pathology demonstrated different dynamics of change after cardiac arrest.

Why it matters

In people who had out-of-hospital cardiac arrest, serum p-tau rose early in those with poor neurological outcome and then fell, while amyloid-beta levels rose over time in most patients. These Alzheimer-related blood markers changed after cardiac arrest but were only weakly linked to neurological outcome, and the study did not test any Alzheimer treatment.

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Study details

Study designcase-control study
Participants80
Effect size19.1%; 80.9%
Evidence strengthHigh

How this study scored 72/100

Published in a leading specialty journal, and it is a randomised controlled trial.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial (from PubMed type “Randomized Controlled Trial”)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	1 / 4	80 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	3 / 7	Cited 39 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.8 citations a year over 5 year(s) since 2023
Impact for its field and year	4 / 6	Cited 11.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 2 other studies in this library
Still being cited	2 / 4	Cited 36 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Kaj Blennow: h-index 220 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 18 institution(s) in 5 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 36877496)
Free to read	2 / 2	Free to read
Total	72 / 100	—

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Read the original

Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Ashton, N. J., Moseby-Knappe, M., Benedet, A. L., Grötschel, L., Lantero-Rodriguez, J., Karikari, T. K., et al. (2023). Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest. JAMA neurology. https://doi.org/10.1001/jamaneurol.2023.0050

Vancouver

Ashton NJ, Moseby-Knappe M, Benedet AL, Grötschel L, Lantero-Rodriguez J, Karikari TK, et al. Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest. JAMA neurology. 2023. doi:10.1001/jamaneurol.2023.0050. PMID: 36877496.

BibTeX

@article{ashton2023-36877496,
  author  = {Ashton, N. J. and Moseby-Knappe, M. and Benedet, A. L. and Grötschel, L. and Lantero-Rodriguez, J. and Karikari, T. K. and Hassager, C. and Wise, M. P. and others},
  title   = {{Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest}},
  journal = {JAMA neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.0050},
  pmid    = {36877496},
  url     = {https://doi.org/10.1001/jamaneurol.2023.0050}
}

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