Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,826–7,850 of 27,380 studies, newest first · page 314 of 1096.
March 2023 25
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2023-03-28
TREM2: A new player in the tumor microenvironment
45/100 ✓ Peer-reviewed TREM2 and immune genetics Seminars in immunology
Key finding: Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-27
Exploiting machine learning models to identify novel Alzheimer's disease biomarkers and potential targets
51/100 ✓ Peer-reviewed Digital health tools Scientific reports
Key finding: We further show that 70% of the upregulated hub genes (among the 28 overlapping hub genes) are AD targets based on a literature review and six miRNA (hsa-mir-16-5p, hsa-mir-34a-5p, hsa-mir-1-3p, hsa-mir-26a-5p, hsa-mir-93-5p, hsa-mir-155-5p) and one transcription factor, JUN, are associated with the upregulated hub genes.
Full summary, score breakdown and related studies → Original source
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2023-03-27
Nutrition and cognitive health: A life course approach
50/100 ✓ Peer-reviewed Prevention and risk Frontiers in public health
Key finding: Mediterranean, Nordic, DASH, and MIND diets are linked to a lower risk of cognitive decline and dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-27
Accelerated Brain Volume Loss Caused by Anti-β-Amyloid Drugs: A Systematic Review and Meta-analysis
78/100 ✓ Peer-reviewed Treatments Neurology
Key finding: These findings reveal the potential for anti-Aβ therapies to compromise long-term brain health by accelerating brain atrophy and provide new insight into the adverse impact of ARIA. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-26
A Systematic Review on Dementia and Translocator Protein (TSPO): When Nuclear Medicine Highlights an Underlying Expression
51/100 ✓ Peer-reviewed Inflammation and the immune system Biomolecules
Key finding: Huge efforts in developing specific and stable tracers for PET/SPECT imaging have been made.
Full summary, score breakdown and related studies → Original source
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2023-03-24
Associations between dietary patterns and dementia-related neuroimaging markers
70/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: -0.011; 95% confidence interval [CI]: -0.018 to -0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: -0.013; 95% CI: -0.024 to -0.001). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-24
Exposure to ultrafine particles and cognitive decline among older people in the United States
68/100 ✓ Peer-reviewed Risk factors Environmental research
Key finding: This study included 5646 participants (mean age 76 years, 65% female). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-24
Therapeutic preference for Alzheimer's disease treatments: a discrete choice experiment with caregivers and neurologists
52/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy
Key finding: Caregivers and neurologists considered incremental clinical benefit over SOC and safety to be highly desirable qualities for a new drug that could clear amyloid plaques and delay clinical progression and indicated a willingness to accept incremental ARIA-E to achieve additional clinical benefits. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-03-24
Examining annual transitions in healthcare spending among U.S. medicare beneficiaries using multistate Markov models: Analysis of medicare current beneficiary survey data, 2003-2019
48/100 ✓ Peer-reviewed Health systems and care delivery Preventive medicine reports
Key finding: Many studies have examined factors associated with individuals of high or low healthcare spending in a given year. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-24
Spatial disparity and factors associated with dementia mortality: A cross-sectional study in Zhejiang Province, China
32/100 ✓ Peer-reviewed Risk factors Frontiers in Public Health
Key finding: Thirty thousand three hundred and ninety-eight deaths attributable to dementia as the underlying or related cause (multiple causes) were reported during 2015-2019. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-24
Food Insecurity and Cognitive Trajectories in Community-Dwelling Medicare Beneficiaries 65 Years and Older
63/100 ✓ Peer-reviewed Risk factors JAMA Network Open
Key finding: Of 3037 participants, a weighted 57.8% (raw count, 1345) were younger than 75 years, 56.2% (raw count, 1777) were women, and most (84.9% [raw count, 2268]) were White. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-23
Penny-wise but Pound-foolish: The Hidden Costs of Step Therapy for Overactive Bladder
53/100 ✓ Peer-reviewed Health systems and care delivery The Journal of Urology
Key finding: Lenore Ackerman *Correspondence: David Geffen School of Medicine, 10833 Le Conte Ave, Box 951738, Los Angeles, CA 90095-1738 telephone: 310-794-0206; E-mail Address: [email protected] https://orcid.org/0000-0003-4192-7649 Department of Urology and Department of Obstetrics and Gynecology, Division of +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-22
Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats
41/100 ✓ Peer-reviewed Drug development Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Key finding: Recent studies have shown that semaglutide also works on the brain, suggesting its potential utility for various diseases, including Parkinson's disease and Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-03-22
Targeting amyloid β in Alzheimer's disease: Meta-analysis of low-dose solanezumab in Alzheimer's disease with mild dementia studies
73/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Pooled MMRM analyses showed a statistically significant effect of solanezumab across cognitive and functional outcome measures. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-22
Lecanemab: Appropriate Use Recommendations
51/100 ✓ Peer-reviewed Treatments The Journal of Prevention of Alzheimer s Disease
Lecanemab (Leqembi®) is approved in the United States for the treatment of Alzheimer's disease (AD) to be initiated in early AD (mild cognitive impairment [MCI] due to AD or mild AD dementia) with confirmed brain amyloid pathology.
Full summary, score breakdown and related studies → Original source
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2023-03-22
Association of Bone Mineral Density and Dementia: The Rotterdam Study
67/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: Low bone mineral density (BMD) and dementia commonly co-occur in older individuals, with bone loss accelerating in patients with dementia due to physical inactivity and poor nutrition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-21
Therapeutic targeting of mitochondria-proteostasis axis by antioxidant polysaccharides in neurodegeneration
41/100 ✓ Peer-reviewed Disease mechanisms Advances in protein chemistry and structural biology
Key finding: Despite a lack of therapies for neurodegenerative diseases, a number of interventions promoting mitochondrial integrity and protein homeostasis (proteostasis) have been shown to delay aging-associated neurodegeneration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-21
Functional and structural alterations of dorsal attention network in preclinical and early-stage Alzheimer's disease
41/100 ✓ Peer-reviewed Brain scans and imaging CNS neuroscience & therapeutics
Key finding: The SCD and aMCI groups showed both decreased ReHo in the right middle temporal gyrus (MTG) and decreased GMV compared to healthy controls (HCs). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-21
Neuronal identity defines α-synuclein and tau toxicity
41/100 ✓ Peer-reviewed Genetics Neuron
Key finding: Whether the underlying preferential neuronal vulnerability is a cell-type-intrinsic property or a consequence of increased expression levels remains elusive. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-21
Nanosensor-Driven Detection of Neuron-Derived Exosomal Aβ 42 with Graphene Electrolyte-Gated Transistor for Alzheimer's Disease Diagnosis
47/100 ✓ Peer-reviewed Biomarkers Analytical chemistry
Key finding: Despite significant progress in the methodologies for detecting AD core biomarkers such as Aβ 42 from serum/plasma, there remains cautious optimism going forward due to its controversial diagnostic value and disease relevance. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-21
Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination
49/100 ✓ Peer-reviewed TREM2 and immune genetics Cell reports
Key finding: The cuprizone mouse model is widely used to simulate demyelination and remyelination occurring in these diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-20
Glucagon-like peptide-1 receptor agonists to expand the healthy lifespan: Current and future potentials
41/100 ✓ Peer-reviewed Drug development Aging cell
Key finding: To help ensure an expanded healthy lifespan for as many people as possible worldwide, there is a need to prevent or manage a number of prevalent chronic diseases directly and indirectly closely related to aging, including diabetes and obesity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-20
Blood biomarkers in mild cognitive impairment patients: Relationship between analytes and progression to Alzheimer disease dementia
40/100 ✓ Peer-reviewed Biomarkers European journal of neurology
Key finding: Blood-based biomarkers are promising tools for the diagnosis of Alzheimer disease (AD) at prodromal stages (mild cognitive impairment [MCI]) and are hoped to be implemented as screening tools for patients with cognitive complaints.
Full summary, score breakdown and related studies → Original source
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2023-03-19
Assessing preparedness for Alzheimer disease‐modifying therapies in Australasian health care systems
43/100 ✓ Peer-reviewed Treatments The Medical Journal of Australia
Key finding: Three deaths have been reported related to treatment with lecanemab.6 Patients receiving DMT require frequent monitoring with MRI brain scans (four or more per year), as there is a high rate of clinically significant amyloid-related imaging abnormalities (ARIA), both brain oedema (ARIA-E) and macro- and microhaemorrhages (ARIA-H). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-03-18
Low-Dose Whole Brain Radiation Therapy for Alzheimer's Dementia: Results From a Pilot Trial in Humans
48/100 ✓ Peer-reviewed Treatments International journal of radiation oncology, biology, physics
Key finding: Our results from 5 patients with eAD treated with LD-WBRT (10 Gy in 5 fractions) demonstrate a positive safety profile and provide preliminary, hypothesis-generating data to suggest that this treatment stabilizes or improves cognition. +2 more findings
Full summary, score breakdown and related studies → Original source
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