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Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review
Twarowski B, Herbet M.. International journal of molecular sciences, 2023-03-30
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the world. It is an incurable process, most often leading to death. This disease is multifactorial, and one factor of this is inflammation. Numerous mediators secreted by inflammatory cells can cause neuronal degeneration. Neuritis may coexist with other mechanisms of Alzheimer's disease, contributing to disease progression, and may also directly underlie AD. Although much has been established about the inflammatory processes in the pathogenesis of AD, many aspects remain unexplained. The work is devoted in particular to the pathomechanism of inflammation and its role in diagnosis and treatment. An in-depth and detailed understanding of the pathomechanism of neuroinflammation in Alzheimer's disease may help in the development of diagnostic methods for early diagnosis and may contribute to the development of new therapeutic strategies for the disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Twarowski, B., & Herbet, M. (2023). Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review. International journal of molecular sciences. https://doi.org/10.3390/ijms24076518
Vancouver
Twarowski B, Herbet M. Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review. International journal of molecular sciences. 2023. doi:10.3390/ijms24076518. PMID: 37047492.
BibTeX
@article{twarowski2023-37047492,
author = {Twarowski, B. and Herbet, M.},
title = {{Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review}},
journal = {International journal of molecular sciences},
year = {2023},
doi = {10.3390/ijms24076518},
pmid = {37047492},
url = {https://doi.org/10.3390/ijms24076518}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Numerous mediators secreted by inflammatory cells can cause neuronal degeneration.
- Neuritis may coexist with other mechanisms of Alzheimer's disease, contributing to disease progression, and may also directly underlie AD.
- Although much has been established about the inflammatory processes in the pathogenesis of AD, many aspects remain unexplained.
- The work is devoted in particular to the pathomechanism of inflammation and its role in diagnosis and treatment.
- An in-depth and detailed understanding of the pathomechanism of neuroinflammation in Alzheimer's disease may help in the development of diagnostic methods for early diagnosis and may contribute to the development of new therapeutic strategies for the disease.
Why it matters
This review discusses inflammation as one factor in Alzheimer's disease and suggests that understanding it better may aid early diagnosis and new treatment strategies. It reports no tested treatment or cure and notes that many aspects of the inflammatory process remain unexplained.
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Study details
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of molecular sciences) |
| Journal's citation record | 3 / 4 | International Journal of Molecular Sciences: journal h-index 426 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 409 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 81.8 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 5 / 6 | Cited 34.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 14 other studies in this library |
| Still being cited | 4 / 4 | Cited 403 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Mariola Herbet: h-index 24 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Medical University of Lublin: institution h-index 295 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37047492) |
| Free to read | 2 / 2 | Free to read |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3390/ijms24076518
- PubMed: 37047492
- Original source →
- Free full text: International Journal of Molecular Sciences →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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