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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 7,926–7,950 of 27,380 studies, newest first · page 318 of 1096.

February 2023 25

  1. 2023-02-26

    INPP5D/SHIP1 regulates inflammasome activation in human microglia

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv : the preprint server for biology

    Key finding: Examination of prefrontal cortex across a large cohort revealed reduced full length INPP5D protein levels in AD patient brains compared to cognitively normal controls.

    Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2023-02-25

    Differences between ante mortem Alzheimer's disease biomarkers in predicting neuropathology at autopsy

    ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) amyloid beta (Aβ)42/phosphorylated tau (p-tau)181 showed excellent performance in differentiating autopsy-confirmed AD and predicting the risk of neuropathological changes in early and late clinical stages. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2023-02-25

    TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair

    ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

    Key finding: The repair of white matter injury is of significant importance for functional recovery after ischemic stroke, and the up-regulation of triggering receptors expressed on myeloid cells 2 (TREM2) after ischemic stroke is neuroprotective and implicated in remyelination. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2023-02-24

    The effects of a mobile-based multi-domain intervention on cognitive function among older adults

    ✓ Peer-reviewed Prevention trials Preventive medicine reports

    Key finding: Using a paired t-test and analysis of variance, this study found that there was a significant mean difference in cognitive function scores between pre and post-intervention (95 % CI = 1.10-1.87, P <.05). +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2023-02-24

    Characteristics of Prior Authorization Policies for New Drugs in Medicare Part D

    ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

    Key finding: This cross-sectional study examines the characteristics of prior authorization policies for new drugs in Medicare Part D to understand whether they are consistent with US Food and Drug Administration indications.

    Full summary, score breakdown and related studies → Original source

  6. 2023-02-23

    Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

    ✓ Peer-reviewed Genetics Nature Genetics

    Key finding: Upon comparing the brain cortex cis -eQTLs (for 12,307 unique genes at FDR<0.05) with a large blood cis- eQTL analysis (n=31,684 samples), we observed that brain eQTLs are more tissue specific than previously assumed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2023-02-23

    Newer glucose-lowering drugs and risk of dementia: A systematic review and meta-analysis of observational studies

    ✓ Peer-reviewed Drug development Journal of the American Geriatrics Society

    Key finding: Newer GLDs were associated with a decreased risk of all-cause dementia in people with T2D. Because of the observational nature and significant heterogeneity between studies, the results should be interpreted with caution. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2023-02-22

    Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: A Focus on Insulin Resistance

    ✓ Peer-reviewed Risk factors International journal of molecular sciences

    Key finding: In addition to genetics and environmental factors, AD is highly associated with metabolic syndrome, defined as the combination of hypertension, hyperlipidemia, obesity and type 2 diabetes mellitus (T2DM). +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2023-02-22

    Single-nucleus transcriptional profiling uncovers the reprogrammed metabolism of astrocytes in Alzheimer's disease

    ✓ Peer-reviewed Genetics Frontiers in molecular neuroscience

    Key finding: Through integrative analysis of single-nucleus sequencing datasets, we revealed metabolic changes in various cell types in the prefrontal cortex of patients with AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2023-02-22

    Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2

    ✓ Peer-reviewed TREM2 and immune genetics Journal of medical genetics

    Key finding: The two Colombian cases presented with early behavioural changes, greater impairments in general cognition and executive function compared with both HC and Ng-FTD groups. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2023-02-21

    Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain

    ✓ Peer-reviewed Long-term cohort studies Proceedings of the National Academy of Sciences of the United States of America

    Key finding: More recently, there is a growing recognition that CP conditions frequently coexist at multiple body sites and may bring more burdens on patients' overall health. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2023-02-21

    Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease

    ✓ Peer-reviewed Genetics JAMA

    Key finding: In this exploratory analysis, the APOE ε3[R145C] missense variant was associated with an increased risk of AD among individuals of African ancestry with the ε3/ε4 genotype. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2023-02-20

    Inclusion of hearing and vision impairments in cognitive training interventions

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia (New York, N. Y.)

    Key finding: Among the 130 articles included in the review, 103 were cognitive training interventions (79%) and 27 were multimodal interventions (21%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2023-02-19

    Ethical issues when using digital biomarkers and artificial intelligence for the early detection of dementia

    ✓ Peer-reviewed Cognitive tests and assessment Wiley interdisciplinary reviews. Data mining and knowledge discovery

    Key finding: It has been suggested that earlier detection and diagnosis may help patients plan for their future, achieve a better quality of life, and access clinical trials and possible future disease modifying treatments. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2023-02-17

    TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

    Key finding: Our results showed that rs157581 (c.339T > C, p.Phe113Leu, F113L) and rs11556505 (c.393C > T, p.Phe131Leu, F131L) were associated with an increased risk of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2023-02-17

    A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mutant allele that produces a confounding reduction in protein product. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2023-02-16

    Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

    ✓ Peer-reviewed Inflammation and the immune system Cell reports

    Key finding: The C9orf72 GGGGCC repeats and microglial receptor TREM2 are both associated with risk for ALS/FTD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2023-02-16

    CSF biomarker concordance with amyloid PET in Phase 3 studies of aducanumab

    ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Robust concordance between CSF biomarkers and amyloid PET visual status was observed (for Aβ42/Aβ40, AUC: 0.90; 95% CI: 0.83-0.97; p < 0.0001), confirming CSF biomarkers as a reliable alternative to amyloid PET in these studies. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2023-02-16

    Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk

    ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The APOE-npscore explained more variance and provided a better model fit for all three CSF measures than APOE ε4-carrier status and ε4 allele count. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2023-02-15

    Blood pressure variability: methodological aspects, clinical relevance and practical indications for management - a European Society of Hypertension position paper ∗

    ✓ Peer-reviewed Vascular contributions Journal of hypertension

    Key finding: Blood pressure is not a static parameter, but rather undergoes continuous fluctuations over time, as a result of the interaction between environmental and behavioural factors on one side and intrinsic cardiovascular regulatory mechanisms on the other side. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2023-02-14

    Mindfulness and Care Experience in Family Caregivers of Persons Living with Dementia

    ✓ Peer-reviewed Caregiving Journal of Alzheimer's disease reports

    Key finding: Greater mindfulness was associated with positive outcomes and inversely associated with negative outcomes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2023-02-14

    Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study

    ✓ Peer-reviewed Cognitive tests and assessment The Lancet regional health. Western Pacific

    Key finding: In univariate analysis, all 29 adiposity and metabolic measures assessed were associated with ' g ' at P < 0.05. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2023-02-14

    New Opportunities for the Early Detection and Treatment of Cognitive Decline: Adherence Challenges and the Promise of Smart and Person-Centered Technologies

    ✓ Peer-reviewed Prevention trials BMC digital health

    Key finding: We discuss state-of-the-art approaches to the early detection and treatment of cognitive decline, adherence challenges associated with these approaches, and the promise of smart and person-centered technologies to tackle adherence challenges.

    Full summary, score breakdown and related studies → Original source

  24. 2023-02-14

    Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals

    ✓ Peer-reviewed Long-term cohort studies Brain, behavior, and immunity

    Key finding: This study aimed to investigate the longitudinal association between decreased lung function and cognitive brain health and to explore underlying biological and brain structural mechanisms. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2023-02-13

    Circadian disruption and sleep disorders in neurodegeneration

    ✓ Peer-reviewed Risk factors Translational neurodegeneration

    Key finding: These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →