Newest studies

Smartphone applications for informal caregivers of chronically ill patients: a scoping review

48/100 ✓ Peer-reviewed Cognitive tests and assessment NPJ digital medicine

Key finding: Of these, smartphone applications were designed for use only by caregivers (n = 15), with a few applications also intended to be used with patients (n = 5), healthcare providers (n = 4), or all three roles (n = 2). +4 more findings

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Inflammation in dementia with Lewy bodies

57/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of disease

Key finding: The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral inflammation in midlife increases the risk of late-onset AD, and data supporting inflammation being associated with disease progression. +1 more finding

• Other Dementias
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond

43/100 ✓ Peer-reviewed Treatments Translational neurodegeneration

Key finding: For example, immunotherapeutic strategies targeting amyloid-β (Aβ) and tau proteins were once deemed almost certainly effective in clinical treatment due to the excellent preclinical results.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer's disease?

41/100 ✓ Peer-reviewed Genetics Therapeutic advances in chronic disease

Key finding: Another approach involves reducing ApoE4 expression by intracerebroventricular antisense oligonucleotides that significantly decreased Aβ pathology in transgenic mice.

• Genetics
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation

41/100 ✓ Peer-reviewed Biomarkers Proceedings of the National Academy of Sciences of the United States of America

Key finding: Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase is closely associated with Alzheimer’s disease (AD). γ-secretase activating protein (GSAP) specifically promotes γ-secretase–mediated cleavage of APP. +1 more finding

Full summary, score breakdown and related studies → Original source

CSF biomarkers for dementia

41/100 ✓ Peer-reviewed Biomarkers Practical neurology

Key finding: We highlight the importance of collaborative working between clinicians and laboratory staff, of preanalytical sample handling, and discuss the various factors influencing interpretation of the results in appropriate clinical contexts.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease

40/100 ✓ Peer-reviewed Inflammation and the immune system Cell metabolism

Key finding: After first detecting elevated histone lactylation in brain samples from both 5XFAD mice and individuals with AD, we observed that H4K12la levels are elevated in Aβ plaque-adjacent microglia.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Physical activity as a protective factor for dementia and Alzheimer's disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies

78/100 ✓ Peer-reviewed Prevention and risk British Journal of Sports Medicine

Key finding: PA was associated with lower incidence of all-cause dementia and Alzheimer's disease, even in longer follow-ups, supporting PA as a modifiable protective lifestyle factor, even after reducing the effects of reverse causation. +4 more findings

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Implementation of an Emergency Power Rule: Compliance of Florida Nursing Homes and Assisted Living Facilities

54/100 ✓ Peer-reviewed Health systems and care delivery Disaster medicine and public health preparedness

Key finding: A total of 219 (32.9%) NHs and 2219 (75.5%) ALFs had an emergency power plan implemented by January 1, 2019. +3 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Enhancing autophagy in Alzheimer's disease through drug repositioning

41/100 ✓ Peer-reviewed Drug development Pharmacology & therapeutics

Key finding: Therefore, targeting autophagy has drawn considerable attention as a therapeutic approach for the treatment of AD. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Network-based stage-specific drug repurposing for Alzheimer's disease

41/100 ✓ Peer-reviewed Drug development Computational and structural biotechnology journal

Key finding: Overall, we propose for further experimental validation 10 candidate repurposed drugs for each AD stage comprising a set of 26 elite candidate repurposed drugs due to overlaps between the three AD stages.

• Treatments

Full summary, score breakdown and related studies → Original source

Multicenter 18F-PI-2620 PET for In Vivo Braak Staging of Tau Pathology in Alzheimer's Disease

42/100 ✓ Peer-reviewed Brain scans and imaging Biomolecules

Key finding: PET data using MRTM2 with the lower cerebellum as the reference region to extract Braak stage-dependent distribution volume ratios, whereas controls were used to define Braak stage PET positivity thresholds. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

58/100 ✓ Peer-reviewed Risk factors Neuron

Key finding: The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy body dementia (LBD). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Serum NfL in Alzheimer Dementia: Results of the Prospective Dementia Registry Austria

53/100 ✓ Peer-reviewed Biomarkers Medicina (Kaunas, Lithuania)

Key finding: Higher sNfL concentrations were associated with worse performance in cognitive tests at baseline, including CERAD (B = −10.084, SE = 2.999, p < 0.001) and MMSE (B = −3.014, SE = 1.293, p = 0.021). +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Analysis of treatment pattern of anti-dementia medications in newly diagnosed Alzheimer's dementia using OMOP CDM

55/100 ✓ Peer-reviewed Treatments Scientific reports

Key finding: Among the 8653 patients with newly diagnosed AD, donepezil was the most commonly prescribed anti-dementia medication (4218; 48.75%), followed by memantine (1565; 18.09%), rivastigmine (1777; 8.98%), and galantamine (494; 5.71%). +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records

57/100 ✓ Peer-reviewed Genetics Frontiers in aging neuroscience

Key finding: Significant progress has been made in identifying genetic risk for AD, but limited studies have investigated how AD genetic risk may be associated with other disease conditions in an unbiased fashion. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Boston cognitive assessment (BOCA) - a comprehensive self-administered smartphone- and computer-based at-home test for longitudinal tracking of cognitive performance

66/100 ✓ Peer-reviewed Cognitive tests and assessment BMC neurology

Key finding: Longitudinal cognitive testing is essential for developing novel preventive interventions for dementia and Alzheimer's disease; however, the few available tools have significant practice effect and depend on an external evaluator. +3 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Tai Chi enhances cognitive training effects on delaying cognitive decline in mild cognitive impairment

43/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Tai Chi enhanced cognitive training effects in MCI. +2 more findings

• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

[Causal treatment of Alzheimer's disease: amyloid antibodies]

31/100 ✓ Peer-reviewed Drug development Innere Medizin (Heidelberg, Germany)

Key finding: Alzheimer's disease (AD) is the most common cause of dementia. +3 more findings

• Treatments

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The ATENción Plena en Enfermedad de Alzheimer (ATENEA-Mindfulness in Alzheimer's Disease) Program for Caregivers: Study Protocol for a Randomized Controlled Trial

38/100 ✓ Peer-reviewed Treatments Healthcare (Basel, Switzerland)

Key finding: There is evidence that suggests that interventions aimed at caregivers, such as mindfulness, may be effective at reducing this burden and emotional issues, such as depression and anxiety, and improving their quality of life. +1 more finding

• Treatments
• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Spatial-Temporal Patterns of β-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis

63/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Further analyses to determine clinical utility are warranted. +1 more finding

Full summary, score breakdown and related studies → Original source

Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study

64/100 ✓ Peer-reviewed Biomarkers Dementia and neurocognitive disorders

Key finding: After adjusting for age, plasma NfL level was higher in subjects with DAT (65.98±84.96 pg/mL), compared to in subjects with SCD (16.90±2.54 pg/mL) or MCI (25.53±10.42 pg/mL, p=0.004). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

The Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases

43/100 ✓ Peer-reviewed Drug development Drug design, development and therapy

Key finding: Growing evidence suggests that GLP-1 RA has the potential to treat neurodegenerative diseases, particularly in diabetes-related Alzheimer's disease (AD) and Parkinson's disease (PD).

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

[Alzheimer's disease-Which substances are at present in phase III studies?]

27/100 ✓ Peer-reviewed Drug development Der Nervenarzt

Key finding: The recent approval of aduhelm/aducanumab by the US Food and Drug Administration (FDA) in June 2021 raised hopes that further substances against Alzheimer's disease might be approved in the near future. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma

48/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in immunology

Key finding: However, the role of TREM2 signaling in the tumor microenvironment of hepatocellular carcinoma (HCC) remains poorly understood. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source