Newest studies

Exercise training improves long-term memory in obese mice

43/100 ✓ Peer-reviewed Prevention trials Life metabolism

Key finding: In contrast, regular physical activity is associated with the prevention or reduced progression of neurodegeneration. +1 more finding

• Lifestyle
• Brain Biology
• Risk Factors

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Alzheimer's Disease CSF Biomarkers as Possible Indicators of Tap-Test Response in Idiopathic Normal Pressure Hydrocephalus

41/100 ✓ Peer-reviewed Biomarkers Brain sciences

Key finding: The Aβ42/Aβ40 ratio was found to be significantly higher in Tap-test responders than non-responders. +1 more finding

• Biomarkers

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Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: disease staging by NF-L, p-tau181, and GFAP

52/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease

Key finding: We found a significant correlation between CSF and plasma levels of Aβ42/40, p-tau181, p-tau231, NF-L, and GFAP, while no CSF-plasma correlation was observed for t-tau and UCHL-1. +4 more findings

• Biomarkers

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Economic Burden of Alzheimer's Disease: A Systematic Review

75/100 ✓ Peer-reviewed Costs and economics Value in health regional issues

Key finding: Twelve of 5536 studies met the inclusion criteria. +4 more findings

• Policy

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Sleep Duration and Executive Function in Adults

41/100 ✓ Peer-reviewed Risk factors Current neurology and neuroscience reports

Key finding: Poor sleep efficiency and sleep fragmentation are linked with poorer executive function and increased risk of dementia during follow-up.

• Risk Factors
• Lifestyle

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Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies

41/100 ✓ Peer-reviewed Drug development Molecular therapy. Methods & clinical development

Key finding: Due to the reducing environment of the cytoplasm, single-chain variable fragment (scFv) aggregation is commonly observed. +4 more findings

• Treatments
• Brain Biology

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Modeling the temporal evolution of plasma p-tau in relation to amyloid beta and tau PET

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma p-tau is a stronger indicator of a temporally linked response to elevated brain Aβ than of tau pathology. +3 more findings

• Biomarkers
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Blood-Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies

43/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: Molecular and genetic changes, such as the isoform ε4 of apolipoprotein E (ApoEε4), a significant genetic risk factor and a promoter of the BBB dysfunction, have been shown to mediate the BBB disruption.

• Brain Biology

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Spatiotemporal Patterns of Hospitalizations Among Older Adults With Co-Presence of Cancer and Dementia in US Counties: 2013–2018

37/100 ✓ Peer-reviewed Risk factors Journal of Applied Gerontology

Key finding: The odds of a county being a hotspot increased significantly with the county-level percentage of dual Medicare-Medicaid beneficiaries (aOR 1.05; 95% CI: 1.04-1.07) and the prevalence of cancer (aOR 1.73; 95% CI: 1.59-1.89), while decreased significantly with increasing degree of rurality (aOR .82; 95% CI: .79-.85) and decreased yearly over time (aOR .72; 95% CI: .68-.75).

• Care Services

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PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice

43/100 ✓ Peer-reviewed Inflammation and the immune system Brain, behavior, and immunity

Key finding: In vitro, PCSK9 significantly increased IL6, IL1B and TNFΑ mRNA levels in Aβ fibrils-treated U373 cells, without influencing inflammasome gene expression, except for an increase in NLRC4 mRNA levels. +4 more findings

• Brain Biology

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Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease

45/100 ✓ Peer-reviewed Brain scans and imaging BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

Key finding: Anti-amyloid mAbs share the feature of producing a marked reduction in total brain Aβ revealed by amyloid positron emission tomography. +1 more finding

• Treatments
• Brain Scans
• Side Effects

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The Unfolded Protein Response in a Murine Model of Alzheimer's Disease: Looking for Predictors

41/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: The endoplasmic reticulum (ER), the main cellular actor involved in proteostasis, appears significantly compromised in AD due to the accumulation of the β-amyloid (Aβ) protein and the phosphorylated Tau protein. +1 more finding

• Brain Biology

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[The role of antidiabetic drugs in the treatment of Alzheimer's disease: systematic review]

53/100 ✓ Peer-reviewed Inflammation and the immune system Problemy endokrinologii

Key finding: Recent studies show that Alzheimer's disease (AD) has many common links with conditions associated with insulin resistance, including neuroinflammation, impaired insulin signaling, oxidative stress, mitochondrial dysfunction and metabolic syndrome. +4 more findings

• Treatments
• Brain Biology

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Potential New Therapeutic Implications of Semaglutide: New Colours of the Rainbow?

41/100 ✓ Peer-reviewed Drug development Diabetes therapy : research, treatment and education of diabetes and related disorders

Key finding: In addition to this, it has emerging potential clinical implications. +3 more findings

• Treatments

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Postacute Care and Long-term Care for LGBTQ+ Older Adults

43/100 ✓ Peer-reviewed Health systems and care delivery Clinics in geriatric medicine

Key finding: LGBTQ + older adults have a high likelihood of accessing nursing home care. +3 more findings

• Care Services

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Consumption of drugs for Alzheimer's disease on the Brazilian private market

41/100 ✓ Peer-reviewed Treatments Revista de saude publica

Key finding: Drug consumption went from 5,000 defined daily doses/1,000 inhabitants, in 2014, to more than 16,000/1,000 inhabitants, in 2020, and all federative units showed positive variation. +4 more findings

• Treatments

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Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive Dementia

54/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: Selected CSF biomarkers at presentation were associated with etiologic diagnoses and treatment responsiveness in patients with heterogeneous causes of RPD. +2 more findings

• Biomarkers
• Diagnosis
• Brain Biology

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ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease

43/100 ✓ Peer-reviewed Biomarkers Autophagy

Key finding: Autophagy is strongly associated with the progression of Alzheimer disease (AD). +4 more findings

• Brain Biology

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Cost-Effectiveness of a Hypothetical Gene Therapy for Alzheimer's Disease: A Markov Simulation Analysis

41/100 ✓ Peer-reviewed Costs and economics Innovations in pharmacy

Key finding: Under the initial assumption that the hypothetical gene therapy grants a 30% risk reduction in disease progression and entry into institutional care, the maximum cost-effective price for gene therapy is $141,126 per treatment using the threshold of $150,000 per quality-adjusted life year (QALY). +3 more findings

• Policy
• Treatments
• Genetics

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Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis

45/100 ✓ Peer-reviewed Disease mechanisms Nature aging

Key finding: Oral administration of chiral Au nanoparticles restored cognitive abilities and ameliorated amyloid-β and hyperphosphorylated tau pathologies in AD mice via alterations in the gut microbiome composition and an increase in the gut metabolite, indole-3-acetic acid, which was lower in serum and cerebrospinal fluid of patients with AD compared with age-matched controls. +1 more finding

• Brain Biology

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The role of TREM2 in Alzheimer's disease: from the perspective of Tau

41/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in cell and developmental biology

Key finding: Several studies have already demonstrated the relationship between TREM2 and Tau.

• Genetics

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Development of a P-tau217 Electrochemiluminescent Immunosensor Reinforced with Au-Cu Nanoparticles for Alzheimer's Disease Precaution

41/100 ✓ Peer-reviewed Biomarkers ACS chemical neuroscience

Key finding: This ECL immunosensor demonstrated high sensitivity and specificity toward p-tau217, along with good reproducibility and stability, providing a new approach for clinical research on Alzheimer's disease.

• Biomarkers

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Assessment for Alzheimer’s Disease Advancement Using Classification Models with Rules

36/100 ✓ Peer-reviewed Health systems and care delivery Applied Sciences

Key finding: An empirical evaluation of the Disease Neuroimaging Initiative data repository (ADNI) datasets shows that the AD-CR algorithm offers good performance (accuracy, sensitivity, etc.) when compared with other machine learning algorithms. +1 more finding

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Palliative care in dementia

43/100 ✓ Peer-reviewed End-of-life care Annals of palliative medicine

Key finding: We discuss the most important and persistent challenges in advanced dementia with the aim to provide excellent care at the end-of-life and caregiver experience. +4 more findings

• End-of-Life Care

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Gut microbiome-targeted therapies for Alzheimer's disease

41/100 ✓ Peer-reviewed Disease mechanisms Gut microbes

Key finding: Frequent bidirectional communications and mutual regulation exist between the gastrointestinal tract and the central nervous system through the gut-brain axis. +4 more findings

• Treatments

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