Newest studies

Perspectives on Diet and Exercise Interaction for Healthy Aging: Opportunities to Reduce Malnutrition Risk and Optimize Fitness

47/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Additionally, supplementation strategies, such as omega-3 fatty acids, creatine, and essential amino acids, are explored alongside the emerging role of the gut microbiota in mediating the benefits of nutrition and exercise. +4 more findings

• Lifestyle

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A Roadmap for Disaster Risk Reduction and Management in Kidney Care

46/100 ✓ Peer-reviewed Prevention and risk Journal of the American Society of Nephrology

Key finding: Key Points Disasters cause significant human suffering, and patients with kidney diseases are uniquely vulnerable. +3 more findings

• Prevention

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Is Australia ready for the rollout of amyloid‐targeting therapies for Alzheimer disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics

51/100 ✓ Peer-reviewed Treatments Internal Medicine Journal

Key finding: Thirty medical specialists (geriatricians, n = 23; psychiatrists, n = 4; neurologists, n = 3) from 30 different clinics participated (public, 76.7%; private, 23.3%), including from metropolitan (73.3%), regional (20.0%) and rural (6.7%) areas. +4 more findings

• Treatments

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Cost-Effectiveness of a Digitally Supported Care Management Program for Caregivers of People With Dementia

55/100 ✓ Peer-reviewed Costs and economics Value in Health

Key finding: CMS was likely cost-effective from the payer but not from a societal perspective, underlining the importance of informal care. +2 more findings

• Policy
• Clinical Trials
• Caregiving

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Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging

46/100 ✓ Peer-reviewed Disease mechanisms Nature aging

Key finding: Reduced CMA is often associated with fewer lysosomes competent for CMA. +1 more finding

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Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease

43/100 ✓ Peer-reviewed Biomarkers Journal of cell science

Key finding: In induced pluripotent stem cell (iPSC)-derived cortical neurons carrying a PSEN1 mutation, known to increase the Aβ42/40 ratio, we observed increased WNT5A-ROR2 clustering and reduced numbers of synapses. +1 more finding

• Brain Biology

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Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker-guided diagnostics

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: NfL demonstrated fair to excellent accuracy in differentiating non-ACS from CU groups (area under the curve [AUC], 0.79 to 0.94). p-tau217 had the highest accuracy for identifying Aβ (AUC 0.94) and tau positron emission tomography status (AUC 0.91). +4 more findings

• Biomarkers

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Clinical Pharmacokinetics of Oral ALZ-801/Valiltramiprosate in a 2-Year Phase 2 Trial of APOE4 Carriers with Early Alzheimer's Disease

69/100 ✓ Peer-reviewed Treatments Clinical pharmacokinetics

Key finding: The steady-state plasma PK results were closely aligned with the previous 2-week PK in the ALZ-801 phase 1b study in APOE4 carrier subjects with AD, as well as a phase 1 7-day PK study in heathy elderly volunteers. +4 more findings

• Treatments
• Clinical Trials

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The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study

69/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma p-tau217 showed larger fold-changes and better accuracy for detecting AD pathology in symptomatic individuals, with greater cross-platform agreement than other p-tau variants. +1 more finding

• Biomarkers

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“By the Time We Knew …”: Poetic Analysis of End‐of‐Life Caregiving Experiences for Rapidly Progressive and Slower‐Duration Dementia Syndromes

47/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: "Rapid-type" caregivers (n = 12) had a median age of 59 (range 45-73) years; 6 were female, and 9 were spouses. +4 more findings

• Caregiving
• End-of-Life Care

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Role of visual function and performance of activities of daily living in cognitive function in patients with mild cognitive impairment: a cross-sectional study

44/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: These findings suggest that visual function plays a crucial role in the cognitive and functional abilities of patients with MCI. +1 more finding

• Early Stage

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Proteomic analysis reveals distinct cerebrospinal fluid signatures across genetic frontotemporal dementia subtypes

55/100 ✓ Peer-reviewed Lewy body dementia Science Translational Medicine

Key finding: We found shared and distinct proteomic alterations in each genetic form of FTD. +4 more findings

• Biomarkers
• Genetics
• Other Dementias

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Identifying natural inhibitors against FUS protein in dementia through machine learning, molecular docking, and dynamics simulation

34/100 ✓ Peer-reviewed Digital health tools Frontiers in Neuroinformatics

Key finding: With a reliable model in hand, our study utilized machine learning techniques, particularly the Random Forest algorithm, to navigate through a vast dataset of phytochemicals. +4 more findings

• Digital Tools

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Informal caregivers’ perspectives on participation in a dementia rehabilitation programme

38/100 ✓ Peer-reviewed Caregiving Scandinavian Journal of Occupational Therapy

Key finding: There is limited experience in combining interdisciplinary rehabilitation for persons with dementia and caregiver support.

• Caregiving

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Spatio-temporal modelling of extreme low birth rates in U.S. counties

36/100 ✓ Peer-reviewed Risk factors BMC Public Health

Key finding: The findings show that elderly, highly educated population structure, city-developed situation, average birth weight, and average age of mother have a significant impact on the stressful downward excess of birth rate, particularly in examples of Charlotte, Sarasota, Collier counties in Florida, and Marin, Santa, Cruuz, San Mateo in California.

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Clinical trials targeting tau should be halted

43/100 ✓ Peer-reviewed Drug development Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Key finding: Experimental drugs lowering brain tau are heralded as improvements in the treatment of Alzheimer's disease. +3 more findings

• Treatments
• Clinical Trials

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Prior authorization and utilization management for post-acute home health in Medicare Advantage: the motivations, players, processes, unique challenges, and impacts on patient care

35/100 ✓ Peer-reviewed Health systems and care delivery Health Affairs Scholar

Key finding: In 2024, 90% of Medicare Advantage (MA) enrollees were in a plan that required prior authorization of home health care. +1 more finding

• Care Services
• Policy

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Interventions and Predictors of Transition to Hospice for People Living With Dementia: An Integrative Review

48/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: Fourteen articles met inclusion criteria after critical appraisal. +4 more findings

• End-of-Life Care

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The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset

57/100 ✓ Peer-reviewed Risk genes beyond APOE Brain

Key finding: We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer's disease (ADAD). +1 more finding

• Genetics

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Informed consent in dementia research: how Public Involvement can contribute to addressing “old” and “new” challenges

37/100 ✓ Peer-reviewed Digital health tools Frontiers in Dementia

Key finding: This paper provides an overview of the perspectives of people with dementia and their carers resulting from Public Involvement activities organized by Alzheimer Europe. +4 more findings

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Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases

45/100 ✓ Peer-reviewed Prevention and risk International Journal of Molecular Sciences

Key finding: Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), which are a consequence of the progressive loss of neuronal function and structure, cause significant cognitive impairment. +2 more findings

• Prevention
• Lifestyle
• Treatments

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Which plasma pTau217 assay should I use in clinical practice? Pandora's box demystified

46/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: This scientific commentary refers to ‘A comprehensive head-to-head comparison of key plasma phosphorylated tau 217 biomarker tests’ by Warmenhoven et al. +1 more finding

• Biomarkers

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Plasma p-tau217 in Alzheimer's disease: Lumipulse and ALZpath SIMOA head-to-head comparison

61/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: The p-tau217 levels measured by the two techniques demonstrated a strong correlation, showing a consistent relationship with CSF p-tau181 levels. +2 more findings

• Biomarkers

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Longitudinal Cognitive Changes in Cerebral Small Vessel Disease

67/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: One hundred ninety-eight of 229 participants had WMH volumes available at both time-points. +4 more findings

• Other Dementias

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Aligning Medications With What Matters Most: Conversations Between Pharmacists, People With Dementia, and Care Partners

43/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: The mean (SD) age of PWD was 81 (8.1) years; 45% were women, 33% Black, and 15% Hispanic. +4 more findings

• Treatments
• Caregiving

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