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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,301–10,325 of 27,380 studies, newest first · page 413 of 1096.

April 2021 25

  1. 2021-04-17

    A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody

    ✓ Peer-reviewed Treatments Alzheimer's research & therapy

    Key finding: BAN2401-G000-201 did not meet the 12-month primary endpoint. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-04-16

    The Gene Coexpression Analysis Identifies Functional Modules Dynamically Changed After Traumatic Brain Injury

    ✓ Peer-reviewed TREM2 and immune genetics Computational and mathematical methods in medicine

    Key finding: However, the dynamic changes of gene expression profiles following TBI have not been fully understood. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-04-16

    TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

    ✓ Peer-reviewed TREM2 and immune genetics Nature communications

    Key finding: Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and latency; however, a mechanism of action is unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-04-16

    Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Overall visual ratings showed complete concordance between radiotracers for both the medial temporal lobe and the neocortex. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-04-15

    [Cognitive impairment in patients with cardiovascular risk: DECOG study]

    ✓ Peer-reviewed Risk factors Semergen

    Key finding: Data from a total of 458 patients were collected. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-04-15

    Placebo controlled phase II clinical trial: Safety and efficacy of combining intranasal insulin & acute exercise

    ✓ Peer-reviewed Clinical trials Metabolic brain disease

    Key finding: However, doses of intranasal insulin of 100 IU or more were observed to result in a 7-fold increase in the likelihood of a level 1 hypoglycemic event for those individuals in the exercise condition. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2021-04-15

    A novel PSEN2 p.Ser175Phe variant in a family with Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    Key finding: So far, autosomal dominantly inherited mutations in "Presenilin 1" (PSEN1), "Presenilin 2" (PSEN2), and "Amyloid precursor protein" (APP) genes were associated with familial AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2021-04-15

    PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer's Disease and Parkinson's Disease

    ✓ Peer-reviewed Costs and economics Frontiers in pharmacology

    Key finding: Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs.

    Full summary, score breakdown and related studies → Original source

  9. 2021-04-15

    Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-04-14

    The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Frontiers in cellular neuroscience

    Key finding: AD is a progressive neurological disorder associated with high rates of brain atrophy.

    Full summary, score breakdown and related studies → Original source

  11. 2021-04-14

    Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: In this longitudinal study of cognitively unimpaired adults, living in the most highly disadvantaged neighborhoods was associated with accelerated degeneration in Alzheimer signature regions and cognitive decline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-04-13

    Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

    ✓ Peer-reviewed Inflammation and the immune system Proceedings of the National Academy of Sciences of the United States of America

    Key finding: These findings may have important implications for antibody therapies aimed at depleting misfolded/aggregated proteins from the human brain, as they may paradoxically trigger inflammation in human microglia.

    Full summary, score breakdown and related studies → Original source

  13. 2021-04-13

    Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    ✓ Peer-reviewed Genetics eLife

    Key finding: Taken together, our results demonstrate that microbiota-derived SCFA are critical mediators along the gut-brain axis which promote Aβ deposition likely via modulation of the microglial phenotype.

    Full summary, score breakdown and related studies → Original source

  14. 2021-04-13

    Reducing acetylated tau is neuroprotective in brain injury

    ✓ Peer-reviewed Biomarkers Cell

    Key finding: This is mediated by S-nitrosylated-GAPDH, which simultaneously inactivates Sirtuin1 deacetylase and activates p300/CBP acetyltransferase, increasing neuronal ac-tau. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-04-13

    Barriers to telehealth access among homebound older adults

    ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

    Key finding: The COVID-19 pandemic resulted in a large and dramatic shift to video-based telehealth use in home-based primary care.

    Full summary, score breakdown and related studies → Original source

  16. 2021-04-12

    Advances in healthcare wearable devices

    ✓ Peer-reviewed Risk factors npj Flexible Electronics

    Key finding: Recently, wearables have also shown encouraging improvements as a drug delivery system; therefore, enhancing its utility towards personalized healthcare. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-04-12

    Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis

    ✓ Peer-reviewed Genetics Aging

    Key finding: Beside the identification of APOE-specific signatures, our findings advocate that this novel approach, based on the concordance across OMIC layers and tissues, is an effective strategy for overcoming the limitations of often underpowered single-OMICS studies.

    Full summary, score breakdown and related studies → Original source

  18. 2021-04-12

    Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly

    ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (Aβ)42 (P = 0.02 and 0.01) but not with P-tau. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-04-12

    Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

    ✓ Peer-reviewed Risk factors Nature reviews. Immunology

    Key finding: A defective epithelial barrier has been demonstrated in allergic and autoimmune conditions such as asthma, atopic dermatitis, allergic rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, coeliac disease and inflammatory bowel disease.

    Full summary, score breakdown and related studies → Original source

  20. 2021-04-12

    Impact of the COVID-19 Pandemic on Older Adults: Rapid Review

    ✓ Peer-reviewed Prevention trials JMIR aging

    Key finding: Our results highlight the need for adequate isolation and protective measures. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-04-12

    Alzheimer's pathogenic mechanisms and underlying sex difference

    ✓ Peer-reviewed TREM2 and immune genetics Cellular and molecular life sciences : CMLS

    Key finding: One prevailing view is that women live longer than men on average of 4.5 years, plus there are more women aged 85 years or older than men in most global subpopulations; and older age is the greatest risk factor for AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-04-10

    Parkinson's disease

    ✓ Peer-reviewed Mild cognitive impairment Lancet (London, England)

    Key finding: There is no reason to postpone symptomatic treatment in people developing disability due to Parkinson's disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-04-10

    Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer

    ✓ Peer-reviewed Biomarkers Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Key finding: Alzheimer's disease (AD) is the most common type of dementia worldwide, characterized by the deposition of neurofibrillary tangles and amyloid-β (Aβ) peptides in the brain.

    Full summary, score breakdown and related studies → Original source

  24. 2021-04-09

    Obstructive Sleep Apnea and Dementia-Common Gene Associations through Network-Based Identification of Common Driver Genes

    ✓ Peer-reviewed Risk factors Genes

    Key finding: 42 common genes were identified between OSA and dementia which were primarily linked to the G-coupled protein receptor (GPCR) and olfactory pathways. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-04-09

    APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease

    ✓ Peer-reviewed Genetics Molecular psychiatry

    Key finding: Compared to individuals homozygous for the APOE3 variant, individuals with the APOE4 variant have a significantly elevated risk of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →