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Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment
Yuzhe Fei, Ruiru Wang, Jiachun Lu, Songhao Peng, Song Yang, Yiting Wang, Kaixuan Zheng, Ran Li et al.. Geriatric nursing (New York, N.Y.), 2023-03-28
Topic: Gut, metabolism and diet
Probiotic supplements were shown to improve cognitive function in Alzheimer's disease (AD) patients. However, it is still unclear whether this applies to older individuals with mild cognitive impairment (MCI). We aimed to explore the effects of probiotic supplementation on multiple neural behaviors in older adults with MCI. Forty-two MCI patients (age > 60 years) were randomly divided into two groups and consumed either probiotics (n=21) or placebo (n=21) for 12 weeks. Various scale scores, gut microbiota measures and serological indicators were recorded pre- and posttreatment. After 12 weeks of intervention, cognitive function and sleep quality were improved in the probiotic group compared with those in the control group, and the underlying mechanisms were associated with changes in the intestinal microbiota. In conclusion, our study demonstrated that probiotic treatment enhanced cognitive function and sleep quality in older MCI patients, thus providing important insights into the clinical prevention and treatment of MCI.
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APA 7th
Fei, Y., Wang, R., Lu, J., Peng, S., Yang, S., Wang, Y., et al. (2023). Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment. Geriatric nursing (New York, N.Y.). https://doi.org/10.1016/j.gerinurse.2023.03.006
Vancouver
Fei Y, Wang R, Lu J, Peng S, Yang S, Wang Y, et al. Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment. Geriatric nursing (New York, N.Y.). 2023. doi:10.1016/j.gerinurse.2023.03.006. PMID: 36990042.
BibTeX
@article{fei2023-36990042,
author = {Fei, Yuzhe and Wang, Ruiru and Lu, Jiachun and Peng, Songhao and Yang, Song and Wang, Yiting and Zheng, Kaixuan and Li, Ran and others},
title = {{Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment}},
journal = {Geriatric nursing (New York, N.Y.)},
year = {2023},
doi = {10.1016/j.gerinurse.2023.03.006},
pmid = {36990042},
url = {https://doi.org/10.1016/j.gerinurse.2023.03.006}
}
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Key findings
- After 12 weeks of intervention, cognitive function and sleep quality were improved in the probiotic group compared with those in the control group, and the underlying mechanisms were associated with changes in the intestinal microbiota.
- In conclusion, our study demonstrated that probiotic treatment enhanced cognitive function and sleep quality in older MCI patients, thus providing important insights into the clinical prevention and treatment of MCI.
Study details
- Participants21
- Evidence strengthLow
How this study scored 70/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Geriatric nursing (New York, N.Y.)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 21 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36990042) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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