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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 7,676–7,700 of 27,380 studies, newest first · page 308 of 1096.

May 2023 25

  1. 2023-05-15

    Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Frontiers in neurology

    Key finding: Recent studies suggest that the intestinal microbiota plays a crucial role in modulating neuro-inflammation which in turn influences Aβ deposition. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2023-05-15

    CSF Aβ40 Levels Do Not Correlate with the Clinical Manifestations of Alzheimer's Disease

    ✓ Peer-reviewed Biomarkers Neuro-degenerative diseases

    Key finding: Participants were classified as hyposecretors (n = 22, median Aβ40 5,870.500 pg/mL, interquartile range [IQR] 1,431), normosecretors (n = 47, median Aβ40 10,817 pg/mL, IQR 3,622), and hypersecretors (n = 7, 19,767 pg/mL, IQR 3,088). +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2023-05-15

    CSF Synaptic Biomarkers in AT(N)-Based Subgroups of Lewy Body Disease

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: LBD/A+T+ and AD cases showed significantly increased CSF levels of synaptic and neuroaxonal biomarkers compared with LBD/A-T- and control subjects. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2023-05-15

    Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man

    ✓ Peer-reviewed Genetics Nature Medicine

    Key finding: The male remained cognitively intact until 67 years of age despite carrying a PSEN1-E280A mutation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2023-05-13

    The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases

    ✓ Peer-reviewed Drug development Diabetology & metabolic syndrome

    Key finding: Type 2 diabetes mellitus (T2DM) is an endocrine disorder due to relative insulin insufficiency and insulin resistance (IR) is associated with increased circulating hIAPP. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2023-05-12

    Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3

    ✓ Peer-reviewed Disease mechanisms Molecular and cellular neurosciences

    Key finding: We recently showed that the absence of tau expression reverts age-associated cognitive and mitochondrial failure by blocking the mitochondrial permeability transition pore (mPTP). mPTP is a mitochondrial complex involved in calcium regulation and apoptosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2023-05-12

    Preanalytical stability of plasma biomarkers for Alzheimer's disease pathology

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Phosphorylated tau 181 (p-tau181), phosphorylated tau 231 (p-tau231), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) concentrations were unchanged both when stored at +4°C and +18°C. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2023-05-12

    TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

    ✓ Peer-reviewed TREM2 and immune genetics Science advances

    Key finding: Here, we found that TREM2 is highly expressed in myeloid subsets, including macrophages and microglia in human and mouse GBM tumors and that high TREM2 expression correlates with poor prognosis in patients with GBM. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2023-05-12

    Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals

    ✓ Peer-reviewed Genetics Alzheimer's & Dementia

    Key finding: New PRSs for dementia significantly improve risk-prediction performance, but still account for less risk than APOE genotype overall. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2023-05-11

    TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer's Disease

    ✓ Peer-reviewed TREM2 and immune genetics International journal of molecular sciences

    Key finding: AD-pathogenesis involves mechanisms that operate outside the brain, and new researches indicate that peripheral inflammation is an early event in the disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2023-05-10

    The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

    Key finding: CUMS induced depressive-like behaviors and cognitive decline in mice, which could be reversed by inhibiting NLRP3 inflammasome. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2023-05-10

    Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study

    ✓ Peer-reviewed Risk factors Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    Key finding: Multivariable linear regressions showed an association of metabolic syndrome with lower performance in attention (β=1.62 seconds, 95% CI=0.20, 3.04) and memory (β=-0.62 words, 95% CI=-1.19, -0.05) that could be driven by associations with elevated fasting glucose and abdominal obesity. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2023-05-10

    Plasma Aβ biomarker for early diagnosis and prognosis of Alzheimer's disease - a systematic review

    ✓ Peer-reviewed Biomarkers Danish medical journal

    Key finding: Plasma Aβ42/40 ratio was inversely correlated with aPET positivity r = -0.48 (95% confidence interval (CI): -0.65--0.31). +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2023-05-08

    Caregiver Burden and Quality of Life Across Alzheimer's Disease Severity Stages

    ✓ Peer-reviewed Caregiving Alzheimer disease and associated disorders

    Key finding: PwADs received, on average, 26 hours of informal care per week. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2023-05-08

    Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial

    ✓ Peer-reviewed Prevention trials Scientific reports

    Key finding: We observed high tolerability and adherence for at-home tACS + CCT.

    Full summary, score breakdown and related studies → Original source

  16. 2023-05-08

    Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease

    ✓ Peer-reviewed Risk genes beyond APOE International journal of molecular sciences

    Key finding: The phenotypic diversity suggests that PSEN1 may be responsible for atypical disease phenotypes or types of disease other than AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2023-05-08

    Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation

    ✓ Peer-reviewed Genetics EMBO reports

    Key finding: The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset Alzheimer's disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2023-05-07

    Treatment strategy for late-life depression

    ✓ Peer-reviewed Risk factors PCN reports : psychiatry and clinical neurosciences

    Key finding: Evidence indicates that LLD is more heterogeneous than depression in younger adults, therefore when treating LLD patients it is necessary to take various conditions and situations into consideration, and to provide detailed treatment that is tailored to each patient.

    Full summary, score breakdown and related studies → Original source

  19. 2023-05-05

    Single-cell analysis reveals inflammatory interactions driving macular degeneration

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: We create a machine-learning pipeline based on recent advances in data geometry and topology and identify activated glial populations enriched in the early phase of disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2023-05-05

    Safety and efficacy of lecanemab for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials

    ✓ Peer-reviewed Treatments Frontiers in aging neuroscience

    Key finding: Our analysis found that lecanemab showed significant positive statistical efficacy with respect to cognition, function, and behavior in patients with early AD though the actual clinical significance is yet to be established. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2023-05-05

    Associations of Midlife Dietary Patterns with Incident Dementia and Brain Structure: Findings from the UK Biobank Study

    ✓ Peer-reviewed Prevention trials The American journal of clinical nutrition

    Key finding: Greater adherence to hPDI, MDS, RFS, and MIND was individually associated with larger brain volumes in specific regions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2023-05-04

    Effect of nutrition in Alzheimer's disease: A systematic review

    ✓ Peer-reviewed Prevention and risk Frontiers in neuroscience

    Key finding: The results show that the western diet pattern is a risk factor for developing AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2023-05-04

    GFAP as a Potential Biomarker for Alzheimer's Disease: A Systematic Review and Meta-Analysis

    ✓ Peer-reviewed Biomarkers Cells

    Key finding: Increasing evidence suggests that blood GFAP levels can be used to detect early-stage AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2023-05-04

    Cardiometabolic multimorbidity, lifestyle behaviours, and cognitive function: a multicohort study

    ✓ Peer-reviewed Vascular contributions The lancet. Healthy longevity

    Key finding: An increasing number of cardiometabolic diseases was dose-dependently associated with the decline in cognitive function score (one disease, β=-0·15 [95% CI -0·17 to -0·13]; two diseases, β=-0·37 [-0·40 to -0·34]; three diseases, β=-0·57 [-0·64 to -0·50]), with comorbid diabetes and stroke (β=-0·23 [-0·29 to -0·17]) contributing most strongly to cardiometabolic disease-associated cognitive decline. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2023-05-04

    Association between chronic pain and risk of incident dementia: findings from a prospective cohort

    ✓ Peer-reviewed Long-term cohort studies BMC medicine

    Key finding: Chronic musculoskeletal pain has been linked to dementia; however, chronic pain typically occurs in multiple sites; therefore, this study was to investigate whether greater number of chronic pain sites is associated with a higher risk of dementia and its subtypes. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →