Newest studies

Caregivers’ Perspectives on Discussions of Medical Treatment Preferences for People Living With Dementia Are Associated With Their Dementia Health Literacy and the Caregiving Relationship

49/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: On average, surveyed caregivers (n = 431) were 78.3 years, had 16 years of education, and were mainly White (88.5%). +4 more findings

• Treatments
• Caregiving

Full summary, score breakdown and related studies → Original source

Hypoactive Delirium: The Critical Need for Collaboration Between Families and Nurses in Prevention, Recognition and Care

50/100 ✓ Peer-reviewed Clinical safety Journal of Advanced Nursing

Key finding: Delirium is a common and serious clinical condition that is associated with several adverse, and sometimes permanent outcomes. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

The intricate interplay between dietary habits and cognitive function: insights from the gut-brain axis

48/100 ✓ Peer-reviewed Prevention trials Frontiers in Nutrition

Key finding: The Mediterranean diet has been associated with improved cognitive performance and a delay in cognitive decline in elderly populations.

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Multi-functional role of apolipoprotein E in neurodegenerative diseases

46/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Aging Neuroscience

Key finding: Specifically, the ApoEε4 allele is a significant risk factor for SAD, while ApoEε2 allele provides protection compared to the more common ApoEε3 allele.

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Ambient air pollution and Alzheimer’s disease and other dementias: a global study between 1990 and 2019

47/100 ✓ Peer-reviewed Long-term cohort studies BMC Public Health

Key finding: Emerging research found air pollution may be associated with incident Alzheimer’s disease (AD) and other dementias. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment

63/100 ✓ Peer-reviewed Lewy body dementia Nature Communications

Key finding: DDC levels increased over time in PD, being significantly associated to higher dosages of dopaminergic treatment. +1 more finding

• Other Dementias
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Environmental risk factors for all-cause dementia, Alzheimer's disease dementia, vascular dementia, and mild cognitive impairment: An umbrella review and meta-analysis

72/100 ✓ Peer-reviewed Risk factors Environmental Research

Key finding: A total of 19 reviews containing 37 meta-analyses were included umbrella review. +4 more findings

• Risk Factors
• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Leveraging Explainable AI for Dementia Classification: A Machine Learning Approach

31/100 ✓ Peer-reviewed Digital health tools International Journal of Applied Sciences & Development

Key finding: In last two decades the growing life expectancy has spiralled the prevalence of neurogenerative disorder such as Dementia among elderly population posing a significant challenge to mental health globally.

• Digital Tools

Full summary, score breakdown and related studies → Original source

The Spectrum of Genetic Risk in Alzheimer Disease

43/100 ✓ Peer-reviewed Genetics Neurology Genetics

Key finding: We discuss the discovery of familial autosomal dominant genes, the identification of candidate genes associated with AD, and genetic variants conferring higher risk of developing AD compared with the general population.

• Genetics

Full summary, score breakdown and related studies → Original source

An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial

93/100 ✓ Peer-reviewed Prevention trials Nature medicine

Key finding: Randomization of this internet-delivered lifestyle intervention tailored to individual dementia risk factors resulted in significantly better cognition in older adults over 3 years.

• Clinical Trials
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative study

42/100 ✓ Peer-reviewed End-of-life care The Lancet Regional Health - Western Pacific

Key finding: The proportion of palliative utilization in cancer deaths started at 21.7% in 2010 and increased to 63.2% by 2020 with the beta coefficient of 0.09 (95% CI: 0.09-0.09). +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Trajectories of general and central obesity beyond middle age in relation to late‐life cognitive decline and dementia

51/100 ✓ Peer-reviewed Brain tissue and pathology Obesity

Key finding: General and central obesity trajectories beyond midlife with persistently high or increasing patterns were significantly associated with an increased risk of developing cognitive decline and dementia in late life. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Molecular Insights into α-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach

40/100 ✓ Peer-reviewed Digital health tools ACS Chemical Neuroscience

Key finding: A machine learning pipeline incorporating principal component analysis and uniform manifold approximation and projection was used to analyze the Raman spectral data and identify significant peaks, resulting in differentiation between sample groups.

• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source

Convening Hispanic/Latino Caregiving Advisors for Inclusive Research in Dementia Palliative Care

37/100 ✓ Peer-reviewed Disparities Journal of Palliative Medicine

Key finding: Key reflections from advisor meetings guided cultural adaptation: lived experiences on dementia caregiving; patient, caregiver, and clinician interactions in the health care system; and limited knowledge and misconceptions of palliative care. +3 more findings

• Health Equity
• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Evaluating the Effectiveness of a Culturally Adapted Dementia Prevention Animation on Ethnically Diverse participants’ Knowledge of Dementia Prevention

36/100 ✓ Peer-reviewed Prevention and risk Clinical Gerontologist

Key finding: Mean performance on knowledge of dementia risk factor mitigation strategies significantly increased after viewing the animation (p < .001), with a clinically meaningful effect (mean change = 3.63). +2 more findings

• Prevention
• Health Equity

Full summary, score breakdown and related studies → Original source

Tau oligomers impair memory and synaptic plasticity through the cellular prion protein

43/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica communications

Key finding: AD brains show significant increase in TauOs compared to healthy controls, their concentration correlating with the severity of cognitive deficits and disease progression. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Evaluating pathogenicity of variants of unknown significance in APP, PSEN1, and PSEN2

43/100 ✓ Peer-reviewed Risk genes beyond APOE Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Key finding: Thirteen variants were associated with reduced Aβ levels in cell-based assays, consistent with a potential protective effect. +1 more finding

• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

Second-generation anti-amyloid monoclonal antibodies for Alzheimer's disease: current landscape and future perspectives

45/100 ✓ Peer-reviewed Treatments Translational neurodegeneration

Key finding: In contrast, second-generation MABs, including aducanumab, lecanemab, donanemab, and gantenerumab directed against pathogenic Aβ species and aggregates have shown that reducing Aβ deposition can be an effective strategy to slow cognitive impairment in AD.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Current practices by Alzheimer's Disease Research Centers to remunerate research participants

52/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Recent guidance recommends remuneration for Alzheimer's disease research participants. +4 more findings

Full summary, score breakdown and related studies → Original source

“There is always a reason why someone is doing something”: The importance of life history and personhood when supporting people with dementia to “wander” in care homes

42/100 ✓ Peer-reviewed Clinical safety Dementia

Key finding: Positive risk taking, supported by policies and procedures, such as resident safety and meaningful activity, may allow staff to manage the benefits and risks associated with wandering.

• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

Mediation of modifiable risk factors in two multidomain dementia prevention trials

47/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

Key finding: We observed no mediation of individual risk factors in the effect of the interventions on dementia incidence. +4 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Enhancing memory performance in older adults through socially engaging cognitive training

30/100 ✓ Peer-reviewed Prevention trials Educational Gerontology

Key finding: This follow-up study builds on our previous research, which showed that combining strategy based cognitive training (ST) with social engagement (SE) improved memory performance in older adults more than social meetings alone. +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection

38/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Neuroscience

Key finding: Our findings show elevated levels of RIPK1 mRNA levels across various forms of tauopathies, in both mouse models and human tissue samples associated with primary and secondary TAU-related disorders. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Identifying gait differences between Alzheimer's disease and dementia with Lewy bodies and their associations with regional amyloid deposition

46/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: The DLB group had reduced stride velocity, step length, and stride width variability, as well as increased double support percentage (%DS) and variability in step length, swing time, and step time compared to the AD and CU groups. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment

46/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s Research & Therapy

Key finding: In a heterogeneous autopsy sample, AD and LB pathology both contribute to cholinergic basal forebrain degeneration whereas hippocampus atrophy is more specifically related to AD pathology. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source