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Identifying gait differences between Alzheimer's disease and dementia with Lewy bodies and their associations with regional amyloid deposition
Salma Elasfar, Hajr Hameed, Bradley F. Boeve, Julie A. Fields, Clifford R. Jack, Kejal Kantarci, Erik K. St. Louis, Val J. Lowe et al.. Alzheimer s & Dementia, 2025-01-27
Topic: Amyloid, tau and blood-test diagnosis
The DLB group had reduced stride velocity, step length, and stride width variability, as well as increased double support percentage (%DS) and variability in step length, swing time, and step time compared to the AD and CU groups. Aβ burden was not associated with any gait outcomes. This study provides additional evidence that gait differs between AD and DLB. Larger studies are needed to investigate associations between Aβ burden and gait outcomes in dementia. HIGHLIGHTS: Gait was more impaired in dementia than in cognitively unimpaired (CU) controls. Compared with Alzheimer's disease (AD), Dementia with Lewy bodies (DLB) had more impaired pace, variability, and postural control. Step length and double support (%) distinguished DLB and AD with moderate accuracy.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Elasfar, S., Hameed, H., Boeve, B. F., Fields, J. A., Jack, C. R., Kantarci, K., et al. (2025). Identifying gait differences between Alzheimer's disease and dementia with Lewy bodies and their associations with regional amyloid deposition. Alzheimer s & Dementia. https://doi.org/10.1002/alz.14351
Vancouver
Elasfar S, Hameed H, Boeve BF, Fields JA, Jack CR, Kantarci K, et al. Identifying gait differences between Alzheimer's disease and dementia with Lewy bodies and their associations with regional amyloid deposition. Alzheimer s & Dementia. 2025. doi:10.1002/alz.14351. PMID: 39868511.
BibTeX
@article{elasfar2025-39868511,
author = {Elasfar, Salma and Hameed, Hajr and Boeve, Bradley F. and Fields, Julie A. and Jack, Clifford R. and Kantarci, Kejal and Louis, Erik K. St. and Lowe, Val J. and others},
title = {{Identifying gait differences between Alzheimer's disease and dementia with Lewy bodies and their associations with regional amyloid deposition}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.14351},
pmid = {39868511},
url = {https://doi.org/10.1002/alz.14351}
}
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Key findings
- The DLB group had reduced stride velocity, step length, and stride width variability, as well as increased double support percentage (%DS) and variability in step length, swing time, and step time compared to the AD and CU groups.
- Aβ burden was not associated with any gait outcomes.
- This study provides additional evidence that gait differs between AD and DLB.
- Larger studies are needed to investigate associations between Aβ burden and gait outcomes in dementia.
- HIGHLIGHTS: Gait was more impaired in dementia than in cognitively unimpaired (CU) controls.
Why it matters
This study found that gait differs between Alzheimer's disease and dementia with Lewy bodies, but Aβ burden was not associated with any gait outcomes. It is about gait differences, not about treating, curing or preventing dementia.
Study details
- Participants420
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 420 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 7 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 4.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Kaylena A. Ehgoetz Martens: h-index 35 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39868511) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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