Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,651–11,675 of 27,380 studies, newest first · page 467 of 1096.
May 2020 25
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2020-05-08
Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study
43/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Of the 1,193 CI patients, 860 (72.1%) were amyloid-positive. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-06
The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study
57/100 ✓ Peer-reviewed Brain scans and imaging Journal of neuroinflammation
Key finding: Our baseline and 2-year imaging findings are compatible with a biphasic trajectory of inflammation in Alzheimer's disease: MCI cases with low baseline but subsequently rising β-amyloid load show correlated levels of microglial activation which then later decline when the β-amyloid load approaches AD levels. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-06
The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG)
41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of clinical medicine
Key finding: Due to the lack of pharmacological treatment for dementia, timely detection of subjects at risk can be of seminal importance for preemptive rehabilitation interventions. +2 more findings
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2020-05-06
Progression of grey and white matter brain damage in Parkinson's disease: a critical review of structural MRI literature
54/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurology
Key finding: The current review summarizes the current knowledge on longitudinal cortical and subcortical grey and white matter MRI findings assessed using T1-weighted and one-tensor diffusion-weighted MRI in Parkinson's disease (PD) patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-05-06
The effect of digital reminiscence therapy on people with dementia: a pilot randomized controlled trial
60/100 ✓ Peer-reviewed Digital health tools BMC geriatrics
Key finding: Digital RT proved an innovative approach to manage PWD and will thus help PWD achieve a better mood and have more opportunities to engage in social interactions. +2 more findings
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2020-05-05
Dendritic Spine and Synaptic Plasticity in Alzheimer's Disease: A Focus on MicroRNA
39/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cell and developmental biology
Key finding: Currently, the microRNAs have emerged as essential regulators of synaptic plasticity. +4 more findings
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2020-05-05
Clinical Features and Experimental Models of Cerebral Small Vessel Disease
39/100 ✓ Peer-reviewed Vascular contributions Frontiers in aging neuroscience
Key finding: There are several types of SVD, though arteriolosclerosis, which is mainly associated with hypertension, aging, and diabetes mellitus, and cerebral amyloid angiopathy (CAA) comprise most SVD cases.
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2020-05-05
Cerebral Microhemorrhage at MRI in Mild Cognitive Impairment and Early Alzheimer Disease: Association with Tau and Amyloid β at PET Imaging
48/100 ✓ Peer-reviewed Tau biomarkers Radiology
Key finding: Growing evidence indicates an association between cerebral microhemorrhages (MHs) and amyloid β accumulation in Alzheimer disease (AD), but to the knowledge of the authors the association with tau burden is unknown. +3 more findings
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2020-05-05
Early Detection of Mild Cognitive Impairment With In-Home Sensors to Monitor Behavior Patterns in Community-Dwelling Senior Citizens in Singapore: Cross-Sectional Feasibility Study
53/100 ✓ Peer-reviewed Digital health tools Journal of medical Internet research
Key finding: We demonstrated that it was both feasible and acceptable to set up these sensors in the community and unobtrusively collect data. +2 more findings
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2020-05-04
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
47/100 ✓ Peer-reviewed Drug development Molecular psychiatry
Key finding: TFEB loss of function significantly reduced the levels of interstitial fluid (ISF) tau in PS19 mice expressing P301S mutant tau and in conditioned media of mutant tau expressing primary neurons, while the secretion of endogenous wild-type tau was not affected. +3 more findings
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2020-05-03
The Braak hypothesis in prion disease with a focus on Creutzfeldt-Jakob disease
39/100 ✓ Peer-reviewed Brain tissue and pathology Neuropathology : official journal of the Japanese Society of Neuropathology
Key finding: Unlike in PD and AD, the initial clinical symptoms of CJD vary by case, and thus the onset lesions must also be various and multiple in the CNS. +4 more findings
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2020-05-02
Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study
48/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease reports
Key finding: Exercise duration and intensity were incrementally increased to 150 min/week and 70-80% of heart rate reserve, respectively. +4 more findings
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2020-05-02
Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease
39/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease reports
Key finding: It is genetically associated with Alzheimer's disease (AD), the most common form of dementia.
Full summary, score breakdown and related studies → Original source
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2020-05-02
Living Arrangements of Older Adults and COVID‐19 Risk: It Is Not Just Nursing Homes
47/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
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2020-05-01
Cognitive impairment in remitted late-life depression is not associated with Alzheimer's disease-related CSF biomarkers
39/100 ✓ Peer-reviewed Risk factors Journal of affective disorders
Key finding: ANCOVA (age and schooling as covariates) displayed statistically significant results with respect to CSF biomarkers' profiles regardless of the socio-demographic divergencies previously identified by one-way ANOVA. +4 more findings
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2020-05-01
High-throughput and efficient multilocus genome-wide association study on longitudinal outcomes
55/100 ✓ Peer-reviewed Genetics Bioinformatics (Oxford, England)
Key finding: Extensive simulations demonstrated that the proposed approach not only provided accurate selection of single nucleotide polymorphisms (SNPs) with comparable or higher power but also robust control of false positives. +1 more finding
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2020-05-01
Convolutional neural networks for classification of Alzheimer's disease: Overview and reproducible evaluation
59/100 ✓ Peer-reviewed Digital health tools Medical image analysis
Key finding: Moreover, we found that more than half of the surveyed papers may have suffered from data leakage and thus reported biased performance. +1 more finding
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2020-05-01
Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review
38/100 ✓ Peer-reviewed Risk factors Environmental science and pollution research international
Key finding: Strong evidence suggests that dysfunction of mitochondria and oxidative stress are involved in neurological diseases.
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2020-05-01
Relationship between cortical iron and tau aggregation in Alzheimer's disease
53/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role in Alzheimer's disease. +2 more findings
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2020-05-01
A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap
41/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology
Key finding: Neuroimaging can track accrued neurodegeneration and other sources of network impairments, metabolomics provides a global small-molecule snapshot that is sensitive to ongoing pathological processes, and genomics characterizes relatively invariant genetic risk factors representing key pathways associated with Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2020-05-01
Subjective Versus Objective Assessment of Cognitive Functioning in Primary Care
47/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Board of Family Medicine : JABFM
Key finding: Screening protocols in which cognitive testing is administered subsequent to patient complaint are prone to underdiagnosis. +1 more finding
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2020-05-01
Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants
62/100 ✓ Peer-reviewed Long-term cohort studies Nature communications
Key finding: We perform a genetic study of three MRI markers of the disease in UK Biobank imaging data and other sources: white matter hyperintensities (N = 42,310), fractional anisotropy (N = 17,663) and mean diffusivity (N = 17,467). +3 more findings
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2020-05-01
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
58/100 ✓ Peer-reviewed TREM2 and immune genetics Immunity
Key finding: Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep understanding of mechanisms controlling diversification. +3 more findings
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2020-05-01
Different Combinations of Mobility Metrics Derived From a Wearable Sensor Are Associated With Distinct Health Outcomes in Older Adults
44/100 ✓ Peer-reviewed Digital health tools The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: When analyzing multiple mobility metrics together, different combinations of mobility metrics are related to specific adverse health outcomes. +3 more findings
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2020-05-01
Microglial activation and tau burden predict cognitive decline in Alzheimer's disease
69/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: Across the whole-sample, the single-modality models indicated significant correlations between the rate of cognitive decline and the first component of each imaging modality. +3 more findings
Full summary, score breakdown and related studies → Original source
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