Newest studies

A Review of Recent Advances in the Management of Alzheimer's Disease

43/100 ✓ Peer-reviewed Drug development Cureus

Key finding: The antidiabetic drugs include NE3107, an anti-inflammatory and insulin sensitizer, and the diabetes mainstream drug metformin. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)

57/100 ✓ Peer-reviewed Prevention trials Brain, behavior, and immunity

Key finding: We assessed the effects of Western versus Mediterranean-like diets on RNAseq-generated transcriptional profiles in lateral temporal cortex and their relationships with longitudinal changes in neuroanatomy, circulating monocyte gene expression, and observations of social isolation and anxiety in 38 socially-housed, middle-aged female cynomolgus macaques (Macaca fascicularis). +4 more findings

• Brain Biology
• Lifestyle
• Prevention

Full summary, score breakdown and related studies → Original source

Associations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort

59/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Higher baseline p-tau181 and NfL were associated with significantly faster decline in most cognitive, physical, and functional outcomes (+1 SD p-tau181: β MMSE = -0.055, 95% CI -0.067 to -0.043, β FCSRT = -0.034, 95% CI -0.043 to -0.025, β fluency = -0.029, 95% CI -0.038 to -0.020, β SPPB = -0.040, 95% CI -0.057 to -0.022, and β 4IADL = -0.115, 95% CI 0.091-0.140. +1 SD NfL: β MMSE = -0.039, 95% CI -0.053 to -0.025, β FCSRT = -0.022, 95% CI -0.032 to -0.012, β fluency = -0.014, 95% CI -0.024 to -0.004, and β 4IADL = 0.077, 95% CI 0.048-0.105). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

43/100 ✓ Peer-reviewed Genetics Cell stem cell

Key finding: However, the mechanisms leading to neurodegeneration remain largely unknown. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Predicting Driving Cessation Among Cognitively Normal Older Drivers: The Role of Alzheimer Disease Biomarkers and Clinical Assessments

62/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: With the aging US population and increasing incidence of Alzheimer disease (AD), understanding factors contributing to driving cessation among older adults is crucial for clinicians. +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome

71/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: In general linear models lower plasma Aβ42/40 was related to lower visuospatial ability, higher total tau was related to lower episodic memory, and higher NfL was related to lower visuospatial ability and lower episodic memory. +2 more findings

• Biomarkers
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease

55/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: These findings show how online testing can now be deployed in patients with AD to measure cognitive function effectively and related to blood biomarkers of the disease. +3 more findings

• Biomarkers
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway

43/100 ✓ Peer-reviewed Disease mechanisms Cell death & disease

Key finding: We report that either αSyn overexpression or αSyn pre-formed fibrils (PFFs) treatment triggers the formation of cofilin-actin rods, synapse disruptors, in cultured hippocampal neurons and in the hippocampus of synucleinopathy mouse models and of LBD patients. +4 more findings

• Brain Biology

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Mason Caregivers Aiming for Resilience, Empowerment, and Support Study: Assessing Family Caregiver Burden Post-Intervention

43/100 ✓ Peer-reviewed Caregiving Journal of applied gerontology : the official journal of the Southern Gerontological Society

Key finding: Family caregivers of older adults living with severe dementia had the highest baseline Zarit Burden Interview (ZBI) score of 27.7 which decreased to 25.0 (p < .05); family caregivers of those living with moderate dementia had a baseline ZBI score of 24.3 which decreased to 20.4 (p < .01); and family caregivers of those living with mild dementia had the lowest baseline ZBI score of 21.0, which decreased to 18.0 (p < .01). +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

Effects of APOE4 on omega-3 brain metabolism across the lifespan

43/100 ✓ Peer-reviewed Prevention and risk Trends in endocrinology and metabolism: TEM

Key finding: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural integrity. +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

SHIP inhibition mediates select TREM2-induced microglial functions

43/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular immunology

Key finding: The R47H variant of TREM2 has emerged as a significant genetic risk factor for AD, leading to a loss-of-function phenotype in mouse AD models. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Alzheimer's disease cerebrospinal fluid biomarkers and kidney function in normal and cognitively impaired older adults

55/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Lower estimated glomerular filtration rate (eGFR) was associated with lower amyloid beta (Aβ)42/tau ratio (p < 0.0001) and Aβ42 (p = 0.002) and higher tau (p < 0.0001) and p-tau (p = 0.0002). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population

55/100 ✓ Peer-reviewed Biomarkers Psychiatry and clinical neurosciences

Key finding: During the follow-up, 151 participants developed dementia, of whom 108 had Alzheimer disease (AD) and 43 non-Alzheimer dementia (non-AD). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Neurofilaments as biomarkers in neurological disorders - towards clinical application

67/100 ✓ Peer-reviewed Biomarkers Nature reviews. Neurology

Key finding: Progress has now moved the measurement of neurofilaments to the doorstep of routine clinical practice for the evaluation of individuals. +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Antiarrhythmic effects of metformin

43/100 ✓ Peer-reviewed Drug development Heart rhythm O2

Key finding: Atrial fibrillation/flutter (AF) is a major public health problem and is associated with stroke, heart failure, dementia, and death. +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Tear biomarkers

43/100 ✓ Peer-reviewed Brain scans and imaging Advances in clinical chemistry

Key finding: Pooled versus single-tear analysis is discussed to underline the benefits and challenges associated with both approaches, offering insights into optimal strategies for tear sample analysis. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer's disease

50/100 ✓ Peer-reviewed Brain scans and imaging GeroScience

Key finding: Prior research indicates that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. +2 more findings

• Genetics
• Brain Scans
• Biomarkers

Full summary, score breakdown and related studies → Original source

Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv : the preprint server for health sciences

Key finding: We identified significant clusters of tau-aggregation in praxis-related regions (e.g., supramarginal gyrus, angular gyrus, temporal, parietal and occipital regions) that were associated with apraxia. +3 more findings

Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Long‐term outcomes after rehabilitation in Medicare Advantage and fee‐for‐service beneficiaries

46/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Among 738 MA and 1488 FFS participants, weighted mean age was 76 years (SD 7.0), 59% were female, and 9% had probable dementia. +4 more findings

• Policy

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Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease

72/100 ✓ Peer-reviewed Genetics Acta Neuropathologica

Key finding: The risk of developing Alzheimer's disease (AD) significantly increases in individuals carrying the APOEε4 allele. +4 more findings

• Genetics

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Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study

71/100 ✓ Peer-reviewed Genetics Neurology and therapy

Key finding: Our TSMR analysis showed a significant positive association between genetic predisposition to methotrexate use and dementia risk. +4 more findings

• Risk Factors

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Plasma GFAP, NfL and pTau 181 detect preclinical stages of dementia

53/100 ✓ Peer-reviewed Biomarkers Frontiers in endocrinology

Key finding: GFAP, NfL and pTau 181 levels in plasma were lower in SCD and MCI than in AD patients. +3 more findings

• Biomarkers
• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

42/100 ✓ Peer-reviewed Tau biomarkers BMC neurology

Key finding: The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers. +3 more findings

• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

The Co-oligomers of Aβ42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level

35/100 ✓ Peer-reviewed Tau biomarkers Neuroscience

Key finding: Aβ42 oligomers (AβO) are key neurotoxins. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Atrial Fibrillation and Dementia: Pathophysiological Mechanisms and Clinical Implications

59/100 ✓ Peer-reviewed Risk factors Biomolecules

Key finding: Individuals with atrial fibrillation are at higher risk of dementia and cognitive dysfunction, as atrial fibrillation increases the risk of cerebral hypoperfusion, inflammation, and stroke.

• Risk Factors

Full summary, score breakdown and related studies → Original source