Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,901–17,925 of 27,380 studies, newest first · page 717 of 1096.
April 2014 25
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2014-04-13
Single App knock-in mouse models of Alzheimer's disease
40/100 ✓ Peer-reviewed Risk genes beyond APOE Nature neuroscience
Key finding: Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-13
Examining the factors associated with depression at the small area level in Ireland using spatial microsimulation techniques
24/100 ✓ Peer-reviewed Risk factors Irish Geography
Key finding: The policy implications of these results are discussed in relation to both the health care literature and current Irish health care policy.
Full summary, score breakdown and related studies → Original source
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2014-04-13
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Biochimica et biophysica acta
Key finding: We evaluate the PI3K/Akt/mTOR axis in the frontal cortex from DS cases (under the age of 40years) and DS with AD neuropathology compared with age-matched controls (Young and Old). +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-11
Requirements of older adults for a daily use of an internet-based cognitive training platform
36/100 ✓ Peer-reviewed Prevention trials Informatics for health & social care
Key finding: However, recent research has demonstrated that an enriched environment can have a beneficial impact on cognitive function in old age. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-11
Nonverbal oral apraxia in primary progressive aphasia and apraxia of speech
45/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: Apraxia of speech, NVOA, and ideomotor apraxia are at least partially separable disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-09
The role of lipid peroxidation in neurological disorders
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of clinical biochemistry and nutrition
Key finding: Recently, the biological roles of products produced by lipid peroxidation have received much attention, not only for their pathological mechanisms associated with neurological disorders, but also for their practical clinical applications as biomarkers.
Full summary, score breakdown and related studies → Original source
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2014-04-08
Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia
36/100 ✓ Peer-reviewed Vascular contributions Magnetic resonance in medicine
Key finding: This review provides a summary statement of recommended implementations of arterial spin labeling (ASL) for clinical applications. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-08
Understanding emergency department staff needs and perceptions in the provision of palliative care
15/100 ⚠ Regulatory decision — not a study End-of-life care Emergency medicine Australasia : EMA
Key finding: Our study suggests that although ED staff expressed confidence regarding symptom management in palliative care, they lacked understanding of the patients in whom a palliative approach could be applied and sought further education in areas, such as end-of-life communication and ethical issues. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-04-08
The cerebrospinal fluid "Alzheimer profile": easily said, but what does it mean?
62/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: A tau/Aβ42 ratio of >0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-08
Mild to moderate Alzheimer dementia with insufficient neuropathological changes
51/100 ✓ Peer-reviewed Biomarkers Annals of neurology
Key finding: These findings support the implementation of a positive amyloid biomarker as an inclusion criterion in future anti-Aβ drug trials.
Full summary, score breakdown and related studies → Original source
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2014-04-07
Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial
65/100 ✓ Peer-reviewed Prevention and risk British journal of sports medicine
Key finding: Aerobic training significantly increased hippocampal volume in older women with probable MCI. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-04
A review of physical and cognitive interventions in aging
36/100 ✓ Peer-reviewed Prevention trials Neuroscience and biobehavioral reviews
Key finding: The ultimate aim is to conclude on recommended multimodal training, in light of contemporary trends in the design of exergaming interventions.
Full summary, score breakdown and related studies → Original source
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2014-04-04
Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy
57/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Mean IGF-1 levels were 144 ± 60 μg/L in generation 1 and 114 ± 37 μg/L in generation 2. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-04
Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration
56/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: We describe a 2-feature biomarker approach to classifying elderly CN subjects that is complementary to the National Institute on Aging-Alzheimer's Association preclinical staging criteria. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-04-03
Sleep and Alzheimer's disease
36/100 ✓ Peer-reviewed Risk factors Sleep medicine reviews
Key finding: Sleep disorders are frequent in Alzheimer's disease (AD), with a significant impact on patients and caregivers and a major risk factor for early institutionalization.
Full summary, score breakdown and related studies → Original source
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2014-04-03
International survey of nursing home research priorities
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: This article reports the findings of a policy survey designed to establish research priorities to inform future research strategy and advance nursing home practice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-02
Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease
69/100 ✓ Peer-reviewed Treatments Neurology
Key finding: PF-04494700 at 20 mg/d was associated with increased adverse events and cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04 month only
Healthy Aging Brain Center improved care coordination and produced net savings
38/100 ✓ Peer-reviewed Health systems and care delivery Health affairs (Project Hope)
Key finding: Over the past two decades the collaborative care model within primary care has proved to be effective in improving care quality, efficiency, and outcomes for older adults suffering from dementia and depression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-04 month only
Alzheimer's disease and nursing homes
38/100 ✓ Peer-reviewed Health systems and care delivery Health affairs (Project Hope)
Key finding: Close to two-thirds of all US nursing home residents have some type of cognitive impairment such as Alzheimer's disease, and the quality of care and quality of life of these people has long been called into question. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-04 month only
[Metabolic syndrome]
38/100 ✓ Peer-reviewed Risk factors Nihon rinsho. Japanese journal of clinical medicine
Key finding: Considerable attention has focused on the prevention of dementia in terms of non-genetic risk factors, including midlife obesity, especially visceral obesity associated with hyperglycemia, hypertension, and hypercholesterolemia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-04-01
Predictors of long-term mortality after severe sepsis in the elderly
47/100 ✓ Peer-reviewed Digital health tools The American journal of the medical sciences
Key finding: The authors identified several factors, including receipt of mechanical ventilation, which were significantly associated with increased long-term mortality for survivors of severe sepsis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Hospital and ED use among Medicare beneficiaries with dementia varies by setting and proximity to death
36/100 ✓ Peer-reviewed Costs and economics Health affairs (Project Hope)
Key finding: Using data from the Health and Retirement Study linked with Medicare claims from the period 2000-08, we found that among community-dwelling elderly fee-for-service Medicare beneficiaries, those who had dementia were significantly more likely than those who did not to have a hospitalization (26.7 percent versus 18.7 percent) and an ED visit (34.5 percent versus 25.4 percent) in each year. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Alzheimer's disease in African Americans: risk factors and challenges for the future
36/100 ✓ Peer-reviewed Disparities Health affairs (Project Hope)
Key finding: Although African Americans were generally underincluded in previous research studies, new and growing evidence suggests that they may be at increased risk of the disease and that they differ from the non-Hispanic white population in risk factors and disease manifestation.
Full summary, score breakdown and related studies → Original source
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2014-04-01
Extrasynaptic NMDA receptor involvement in central nervous system disorders
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain injury. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-04-01
Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases
36/100 ✓ Peer-reviewed Drug development Biochemical Society transactions
Key finding: Recently, it has been shown that in patients with AD (Alzheimer's disease) and, to some degree, in patients with PD (Parkinson's disease) insulin signalling is impaired. +2 more findings
Full summary, score breakdown and related studies → Original source
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