Newest studies

Hearing loss, diet, and cognitive decline: interconnections for dementia prevention

51/100 ✓ Peer-reviewed Prevention and risk The Journal of Prevention of Alzheimer s Disease

Key finding: Among 5,145 participants included in the analyses, 747 (14.5 %) reported hearing loss, including 207 Black adults and 199 White adults. +4 more findings

• Prevention
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease

43/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer's research & therapy

Key finding: We identified common disease endotypes, such as dedifferentiation, dysregulation of synaptic signaling, repression of mitochondrial function and metabolism, and inflammation. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Effects of intermittent theta burst stimulation on cognitive and swallowing function in patients with MCI and dysphagia risk: a randomized controlled trial

42/100 ✓ Peer-reviewed Clinical safety BMC Geriatrics

Key finding: The MoCA score and the SCWT duration of the real group improved significantly compared with that of the sham group. +4 more findings

• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment

43/100 ✓ Peer-reviewed Brain tissue and pathology Acta Neuropathologica Communications

Key finding: Pathological analysis revealed early abnormal aggregates in spinal cord motor neurons, cortical neurons, and muscle cells of homozygous mice. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Retinal dysfunction in APOE4 knock-in mouse model of Alzheimer's disease

46/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: APOE4-KI mice showed impaired retinal structure, vasculature, function, vision, increased gliosis and neuroinflammation, and downregulation of synaptogenesis. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Advance Care Planning Billing Codes Associated With Decreased Healthcare Utilization in Neurological Disease

41/100 ✓ Peer-reviewed Health systems and care delivery Journal of healthcare management / American College of Healthcare Executives

Key finding: After matching for demographic and health variables, usage of ACP codes was associated with significantly fewer hospitalizations for Alzheimer's disease patients. +4 more findings

Full summary, score breakdown and related studies → Original source

Antihypertensive Deprescribing and Functional Status in VA Long‐Term Care Residents With and Without Dementia

47/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: In long-term care residents, ADL scores worsened by a mean of 0.29 points (95%CI = 0.27, 0.31) per 3 months and antihypertensive deprescribing did not impact this worsening (difference between groups -0.04 points every 3 months, 95%CI = -0.15, 0.06). +4 more findings

• Side Effects

Full summary, score breakdown and related studies → Original source

Robots in Nursing Homes: Helping Nurses Detect and Prevent Falls

35/100 ✓ Peer-reviewed Clinical safety Advances in Geriatric Medicine and Research

Key finding: There are various systems designed to detect falls and alert staff, including those utilizing wearable devices, ambience sensors and cameras (vision) as well as fusion systems. +4 more findings

• Digital Tools
• Prevention
• Care Services

Full summary, score breakdown and related studies → Original source

Cognitive training with adaptive algorithm improves cognitive ability in older people with MCI

34/100 ✓ Peer-reviewed Prevention trials Aging Clinical and Experimental Research

Key finding: Despite this, most research has focused on confirming the efficacy of training outcomes, with few studies examining the correlation between performance and results across various stages of training. +2 more findings

• Diagnosis
• Lifestyle

Full summary, score breakdown and related studies → Original source

Exposure to School Racial Segregation and Late-Life Cognitive Outcomes

55/100 ✓ Peer-reviewed Brain tissue and pathology JAMA Network Open

Key finding: The study sample included 3566 Black (16 104 observations) and 17 555 White (90 874 observations) participants. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Transcriptomic predictors of rapid progression from mild cognitive impairment to Alzheimer's disease

57/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s Research & Therapy

Key finding: We discovered a remarkable gender-specific difference in DEGs that distinguish P-MCI from S-MCI. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

ReIU: an efficient preliminary framework for Alzheimer patients based on multi-model data

47/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in Public Health

Key finding: The rising incidence of Alzheimer's disease (AD) poses significant challenges to traditional diagnostic methods, which primarily rely on neuropsychological assessments and brain MRIs. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Endothelial cells as key players in cerebral small vessel disease

43/100 ✓ Peer-reviewed Vascular contributions Nature reviews. Neuroscience

Key finding: However, these interventions have limited effects, a proportion of individuals with sporadic SVD do not have hypertension, and SVD shows strong familial and genetic underpinnings. +4 more findings

• Other Dementias
• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

A Nurse‐Initiated Protocol for Interprofessional Management of Changed Behaviours in Hospital Patients With Dementia and/or Delirium: A Modified e‐Delphi Study

47/100 ✓ Peer-reviewed Clinical safety Journal of Advanced Nursing

Key finding: Fifty-three experts participated (eight completed all rounds). +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

A qualitative study on the impact and participation in the AGELESS multidomain intervention: Insights from older adults with cognitive frailty and their caregivers

42/100 ✓ Peer-reviewed Prevention trials BMC Public Health

Key finding: The analysis revealed five distinct themes: (1) impact of the program, (2) facilitators enhancing participation, (3) barriers hindering participation, (4) suggestions for improving participation and (5) challenges to adopt digital platforms. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Enhancing Cognitive Functioning in Dementia Through Art Therapy: A Randomized Trial Based on the Expressive Therapies Continuum (ETC) Framework (Améliorer le fonctionnement cognitif chez les personnes atteintes de démence par l’art-thérapie : Un essai randomisé fondé sur le Continuum des thérapies expressives [CTE])

35/100 ✓ Peer-reviewed Cognitive tests and assessment Canadian Journal of Art Therapy

Key finding: This study (RCT) investigated the impact of Expressive Therapies Continuum (ETC)-based art therapy on cognitive function and quality of life among older adults with dementia living in a complex care setting. +2 more findings

• Clinical Trials
• Diagnosis
• Treatments

Full summary, score breakdown and related studies → Original source

Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder

65/100 ✓ Peer-reviewed How common it is Brain

Key finding: Accordingly, we hypothesized that plasma biomarkers associated with AD pathology might be useful to predict DLB in a cohort of idiopathic/isolated REM sleep behaviour disorder (iRBD), an incipient synucleinopathy. +4 more findings

• Biomarkers
• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Prevalence of Dementia Among US Adults With Autism Spectrum Disorder

55/100 ✓ Peer-reviewed How common it is JAMA Network Open

Key finding: This cohort study evaluates the prevalence of dementia diagnoses among US adults with autism spectrum disorder.

Full summary, score breakdown and related studies → Original source

In Vivo Head-to-Head Comparison of [18F]GTP1 with [18F]MK-6240 and [18F]PI-2620 in Alzheimer Disease

39/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine

Key finding: [18F]GTP1 exhibited retention patterns that correlated with [18F]PI-2620 and [18F]MK-6240 for all Braak regions (except Braak II). +3 more findings

Full summary, score breakdown and related studies → Original source

The relationship between sociodemographic characteristics, lifestyle, and diet quality with diabetes risk in overweight and obese Turkish adults

39/100 ✓ Peer-reviewed Prevention and risk BMC Public Health

Key finding: According to FINDRISC score, 38.1% of adults were at mild risk, 21.9% were at moderate risk, and 20.9% were at high risk. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Disaster risk reduction integration into school curriculum: A global analysis

38/100 ✓ Peer-reviewed Prevention and risk European Journal of Sustainable Development Research

Key finding: School curricula, as conduits for disaster resilience, are explored using the lens of ideal DRR education dimensions to predict achievements, challenges, and opportunities to strengthen this integration imperative. +4 more findings

• Prevention

Full summary, score breakdown and related studies → Original source

Microbiome: A Key Regulator of Body-Brain Interactions

43/100 ✓ Peer-reviewed Disease mechanisms Advances in experimental medicine and biology

Key finding: The evolution of the gut microbiota throughout an individual's life-from early developmental influences like birth mode and antibiotic use to changes associated with aging and neurodegenerative conditions-highlights its dynamic nature.

Full summary, score breakdown and related studies → Original source

Hearing Loss and Alzheimer Disease

43/100 ✓ Peer-reviewed Risk factors Current topics in behavioral neurosciences

Key finding: Recently, thanks to the use of functional MRI and EEG it has been shown that untreated HL can expose patients with cognitive decline to a higher risk of developing Alzheimer Disease (AD).

• Risk Factors

Full summary, score breakdown and related studies → Original source

DNA Methylation in Alzheimer's Disease

71/100 ✓ Peer-reviewed Genetics Current topics in behavioral neurosciences

Key finding: Involving the addition of a methyl group to the fifth carbon of the cytosine pyrimidine base, DNA methylation is generally thought to be associated with the silencing of gene expression.

Full summary, score breakdown and related studies → Original source

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies

43/100 ✓ Peer-reviewed Genetics Current protein & peptide science

Key finding: While the APOE gene's ε4 allele considerably increases the chance of developing AD, the ε2 allele is protective compared to the prevalent ε3 variant. +2 more findings

• Genetics
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source