Newest studies

Alterations in non-REM sleep and EEG spectra precede REM-sleep deficits in a model of synucleinopathy

40/100 ✓ Peer-reviewed Risk factors Journal of Parkinson s Disease

Key finding: Neuroinflammation was assessed by examining microglial (Iba1) and astrocytic (GFAP) activation in key sleep-regulating brain regions. +3 more findings

• Other Dementias
• Brain Biology
• Lifestyle

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Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease

56/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: After adjusting for demographics, apolipoprotein E (APOE) ε4 status, cognition, and comorbidities, the highest tertile of REM latency was associated with higher Aβ burden (β = 0.08, 95% confidence interval [CI]: 0.03 to 0.13, p = 0.002), elevated p-tau181 (β = 0.19, 95% CI: 0.02 to 0.13, p = 0.002), and reduced BDNF levels (β = -0.47, 95% CI: -0.68 to -0.13, p = 0.013), compared to the lowest tertile. +4 more findings

• Biomarkers
• Lifestyle

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Prevalence of dementia in Singapore: Changes across a decade

57/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: The weighted prevalence of dementia based on the 10/66 Diagnostic Research Group (DRG) criteria was 8.8% (95% confidence interval [CI]: 7.3-10.7) in the WiSE 2023 study compared to 10% in the WiSE 2013 study (95% CI: 8.7-11.5). +4 more findings

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Offspring education and cognitive health: A comparison between Hispanic and White older adults in the United States

47/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Higher offspring education (> 12 years) was associated with higher baseline cognitive scores and faster cognitive decline. +4 more findings

• Health Equity

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Cross‐Sectional Comparison of Structural MRI Markers of Impairment in a Diverse Cohort of Older Adults

50/100 ✓ Peer-reviewed Brain scans and imaging Human Brain Mapping

Key finding: Higher BAG (pDeepBrainNet = 0.0002; pBrainAgeR = 0.00117) and lower hippocampal volume (p = 0.0015) and cortical thickness (p < 0.0001) were associated with worse clinical status (higher CDR). +1 more finding

• Brain Scans

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Profiles of social vulnerability for flood risk reduction

45/100 ✓ Peer-reviewed Prevention and risk International Journal of Disaster Risk Reduction

Key finding: We conclude by discussing how profile typologies and their geographies advance understanding of social vulnerability and can inform strategies for equitable flood adaptation. • Developed profiles of social vulnerability and flood exposure in the United States. • We employed Hierarchical Clustering on Principal Components. • The profiles revealed six major archetypes of compound vulnerabilities. • We contrasted the results with a social vulnerability index. • Informs intersectional social vulnerability modeling and adaptation planning.

• Prevention

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Changes in Out-of-Pocket Drug Expenditures Among Medicare Beneficiaries With Dementia Under the Inflation Reduction Act: A Simulation Study

46/100 ✓ Peer-reviewed Costs and economics Value in Health

Key finding: The Inflation Reduction Act Medicare Part D benefit redesign will reduce OOP drug spending for beneficiaries with dementia, resulting in potentially marked savings not only for low-income beneficiaries and beneficiaries with a high comorbidity burden but also for higher-income beneficiaries.

• Policy
• Treatments

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Cytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan

33/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Neuropathology & Experimental Neurology

Key finding: HS-A is seen as a co-pathology in cases with AD, limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC), and frontotemporal degeneration. +4 more findings

• Brain Biology

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Gait, balance, and physical performance as markers of early Alzheimer's disease and related dementia risk

39/100 ✓ Peer-reviewed Disparities Journal of Alzheimer s Disease

Key finding: Physical performance may be a valuable tool in early dementia detection in clinical settings and could identify targets for early intervention. +3 more findings

• Early Stage

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Dementia Friendly Buildings—Approach on Architectures

41/100 ✓ Peer-reviewed Caregiving Buildings

Key finding: Integrating safety precautions such as slip-resistant flooring, handrails, and accessible bathrooms helps mitigate falls for the cognitively impaired. +4 more findings

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Educational attainment, Aβ, tau, and structural brain reserve in Alzheimer's disease

63/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A+/High-EA individuals exhibited slower cognitive decline in global cognition and language domains than A+/Low-EA individuals. +4 more findings

• Brain Biology

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Light-chain split luciferase assay implicates pathological NOTCH3 thiol reactivity in inherited cerebral small vessel disease

41/100 ✓ Peer-reviewed Vascular contributions Journal of Biological Chemistry

Key finding: The vast majority of these mutations result in alterations in the number of cysteines in the gene product. +2 more findings

• Other Dementias

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Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration

42/100 ✓ Peer-reviewed Inflammation and the immune system Advanced Science

Key finding: In this study, it is demonstrated that HSD significantly induces enhanced reactivity of DAA-like astrocytes in the hippocampal CA3 region of mice, with this reactivity being critically dependent on neuronal tau pathology. +3 more findings

• Brain Biology

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Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

52/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Pharmacology

Key finding: Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation. +2 more findings

• Brain Biology

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THE EFFECT OF BOARDGAMES THERAPY: SCRABBLE ON COGNITIVE ABILITIES IN ELDERLY WITH DEMENTIA

27/100 ✓ Peer-reviewed Cognitive tests and assessment Jurnal Riset Kesehatan Poltekkes Depkes Bandung

Key finding: Nine therapy sessions were given, and the eighth session showed a significant improvement after the implementation of scrabble game therapy. +1 more finding

• Treatments

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Alzheimer’s Disease: Exploring Pathophysiological Hypotheses and the Role of Machine Learning in Drug Discovery

43/100 ✓ Peer-reviewed Digital health tools International Journal of Molecular Sciences

Key finding: Emerging evidence suggests that while amyloid-beta (Aβ) accumulation is central to AD, it may not be the primary driver but rather part of a broader pathogenic process.

• Treatments
• Digital Tools
• Brain Biology

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Relationships Among Caregiver Burden, Psychological Flexibility Processes, and Depressive Symptoms in Family Caregivers of People with Dementia: Path Analyses

40/100 ✓ Peer-reviewed Caregiving Journal of Applied Gerontology

Key finding: Participants' mean age was 59.5 years, ranging between 24 and 87 years. +4 more findings

• Caregiving

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Prevalence, aetiology, and service mapping of dementia in rural Uganda. Part of DEPEND Uganda (Dementia Epidemiology, unmet Need and co-Developing Solutions in Uganda)

38/100 ✓ Peer-reviewed Getting a diagnosis Wellcome Open Research

Key finding: This is the first study in Africa using blood-based and retinal imaging biomarkers to examine pathological processes underlying dementia, and systematically map services available for people with dementia. +4 more findings

• Diagnosis
• Health Equity

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Novel Monoclonal Antibodies for the Treatment of Alzheimers Disease using KISUNLA Drug

26/100 ✓ Peer-reviewed Treatments International Journal of Advanced Research in Science Communication and Technology

Key finding: For those with early-stage sympathetic Alzheimer's disease who desperately require an efficient therapeutic alternative, Kisunla shows extremely significant results

• Treatments

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Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair

51/100 ✓ Peer-reviewed TREM2 and immune genetics Immunity

Key finding: A population of recruited lipid-associated macrophages (LAMs) has been reported to populate the diseased liver alongside resident Kupffer cells (KCs). +3 more findings

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Associations of early-onset coronary heart disease and genetic susceptibility with incident dementia and white matter hyperintensity: A prospective cohort study

47/100 ✓ Peer-reviewed Vascular contributions The Journal of Prevention of Alzheimer s Disease

Key finding: Early-onset CHD and genetic susceptibility are associated with a higher risk of incident dementia and a larger WMH volume. +1 more finding

• Risk Factors
• Genetics

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Efficacy of a group-based 8-week multicomponent cognitive training on cognition, mood and activities of daily living among healthy older adults: A two-year follow-up of a randomized controlled trial

54/100 ✓ Peer-reviewed Prevention trials The Journal of Prevention of Alzheimer s Disease

Key finding: Compared with the control arm (n = 36), the TEAM-V Program (n = 39) was associated with significantly improved general cognition (MoCA, P = 0.02) at 2 years. +4 more findings

• Clinical Trials

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The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and Alzheimer Disease

44/100 ✓ Peer-reviewed Inflammation and the immune system American Journal Of Pathology

Key finding: In parallel with the number of patients with AD, the number of cancer survivors is estimated to increase significantly, and up to 80% of cancer patients treated with chemotherapy will develop cognitive deficits, termed chemotherapy-related cognitive impairment. +1 more finding

• Brain Biology
• Genetics

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A de novo, mosaic and complex chromosome 21 rearrangement causes APP triplication and familial autosomal dominant early onset Alzheimer disease

43/100 ✓ Peer-reviewed Brain tissue and pathology Scientific Reports

Key finding: Copy number analysis identified an increased number of APP copies and genome sequencing (GS) revealed the underlying complex genomic rearrangement (CGR) including a triplication of APP with two unique breakpoint junctions (BPJs). +1 more finding

• Genetics
• Digital Tools

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Enhanced detection of mild cognitive impairment in Alzheimer’s disease: a hybrid model integrating dual biomarkers and advanced machine learning

43/100 ✓ Peer-reviewed Mild cognitive impairment BMC Geriatrics

Key finding: As a result, in this study, CerebroSpinal Fluid (CSF) biomarker information is combined with hippocampal volumes to differentiate between MCI and AD.

• Early Stage
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source