Newest studies

Spatial Bayesian Small Area Estimation of Stunting Prevalence at the Subdistrict Level

26/100 ✓ Peer-reviewed Risk factors InPrime: Indonesian Journal of Pure and Applied Mathematics

Key finding: Compared to direct estimation, the HB SAE model reduced the number of sub-districts with Relative Standard Errors (RSE) above 25% from 55 to 44, achieving lower Mean Squared Error (MSE) values and more stable estimates. +1 more finding

Full summary, score breakdown and related studies → Original source

Mapping the Association of Cerebral Small Vessel Disease, Gray Matter Integrity, and Cognitive Function

46/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: Complementing previous research that focuses on CSVD and white matter changes, our study highlights abnormal gray matter integrity as a possible link between small vessel pathology and cognitive disorders.

• Other Dementias

Full summary, score breakdown and related studies → Original source

The cost of a Mediterranean Diet and walking intervention to reduce risk of dementia and improve quality of life in independent living populations in Australia: The MedWalk randomised controlled trial

41/100 ✓ Peer-reviewed Prevention trials British Journal Of Nutrition

Key finding: Change in QoL (decreased, maintained or improved) was determined using a cross-tabulation test. +3 more findings

• Clinical Trials
• Lifestyle
• Prevention

Full summary, score breakdown and related studies → Original source

Single-nucleus RNA sequencing reveals GABAergic vulnerability and reactive gliosis driven by loss of TDP-43

34/100 ✓ Peer-reviewed Brain tissue and pathology iScience

Key finding: mice, compared with that of 5xFAD mice, a well-established AD mouse model with β-amyloid plaque pathology. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

A simulation study comparing anticholinergic drug use with polypharmacy for risk of death, dementia, and delirium in UK Biobank

49/100 ✓ Peer-reviewed Long-term cohort studies The Journals of Gerontology Series A

Key finding: Odds ratios for death, dementia, and delirium using anticholinergic-polypharmacy pseudoscales (median = 1.09-1.10) were greater than those of general-polypharmacy pseudoscales (1.05-1.06). +2 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Elevated gonadotropins and risk of dementia in Chinese adults aged over 80: a cross-sectional study

51/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Aging Neuroscience

Key finding: Elevated FSH and reduced LH may be associated with poorer cognition and an increased risk of AD-D in very old Chinese adults, particularly in males. +4 more findings

• Diagnosis
• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction

47/100 ✓ Peer-reviewed Genetics Autophagy

Key finding: : Aβ-β-amyloid; AD-Alzheimer disease; APMS-affinity purification mass spectrometry; APOE-apolipoprotein E; APP-amyloid beta precursor protein; BafA1-bafilomycin A1; CMA-chaperone-mediated autophagy; COP-coatomer; ER-endoplasmic reticulum; ERAD-endoplasmic reticulum-associated degradation; ERGIC-endo

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease

42/100 ✓ Peer-reviewed Genetics Neurological Sciences

Key finding: Recognizing both the therapeutic potential and the organizational challenges associated with anti-amyloid monoclonal antibodies, the document aims to guide healthcare policymakers, institutions, and practitioners toward a coordinated reorganization of the diagnostic-therapeutic pathway, ensuring the safe and effective use of these treatments and ultimately improving outcomes and quality of care for individuals with Alzheimer's disease.

• Treatments
• Genetics
• Diagnosis

Full summary, score breakdown and related studies → Original source

Assessing the causal association between celiac disease and Alzheimer disease and frontotemporal dementia: A bidirectional Mendelian randomization approach

34/100 ✓ Peer-reviewed Genetics Medicine

Key finding: Single-nucleotide polymorphisms (SNPs) strongly associated with each condition were selected as genetic instruments. +2 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease

60/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: The aim of this study was to evaluate longitudinal associations of multimodal core 1 AD biomarkers with cognition in a cognitively unimpaired (CU) population at increased risk of AD dementia. +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning

45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD

Key finding: We found synergistic interaction between epilepsy and enrollment by age.

• Down Syndrome
• Digital Tools

Full summary, score breakdown and related studies → Original source

Effect of obicetrapib, a potent cholesteryl ester transfer protein inhibitor, on p-tau217 levels in patients with cardiovascular disease

63/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: Obicetrapib significantly slowed AD biomarker progression over 12 months in participants with ASCVD, with the greatest effects in ApoE4 carriers. +4 more findings

• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function

44/100 ✓ Peer-reviewed Laboratory science Neuron

Key finding: Single-cell RNA sequencing (scRNA-seq) profiling of microglia revealed that Trem2 T96K impairs the transition of homeostatic microglia into disease-associated microglia (DAM) in female 5xFAD mice. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Family In The Loop: Enabling Family Involvement and Person-Centered Dementia Care at Long-Term Care Facilities with Collaborative AI Tools

46/100 ✓ Peer-reviewed Caregiving Proceedings of the ACM on Human-Computer Interaction

Key finding: Person-centered care provides a critical framework for dementia support in long-term care facilities, emphasizing attention to each resident's evolving needs, personal history, preferences, and values. +1 more finding

• Caregiving
• Digital Tools
• Care Services

Full summary, score breakdown and related studies → Original source

Balancing Caregiving and Self-Care: Exploring Mental Health Needs of Alzheimer's and Dementia Caregivers

39/100 ✓ Peer-reviewed Caregiving Proceedings of the ACM on Human-Computer Interaction

Key finding: Family caregivers of individuals with AD/ADRD face significant mental health challenges due to long-term caregiving responsibilities. +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

The measurement of cognition in large-scale cross-national surveys: lessons from the Health and Retirement Study International Network of Studies and the Harmonized Cognitive Assessment Protocol

51/100 ✓ Peer-reviewed Getting a diagnosis The Journals of Gerontology Series B

Key finding: These lessons emphasize the importance of ensuring tests are feasible across both high-income countries and LMICs, maintaining consistency within studies and over time, and designing comprehensive cognitive batteries for improved measurement precision of general and domain-specific phenotypes. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel

44/100 ✓ Peer-reviewed Genetics Nature Metabolism

Key finding: Although SORT1 also shows genome-wide association with Alzheimer disease and frontotemporal lobe dementia, the most prevalent forms of age-related dementias, sortilin's contribution to human brain lipid metabolism and health remains unclear. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

The joint association of obesity and physical activity on cognitive function in Down syndrome

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD

Key finding: In adults with and without DS, low moderate-to-vigorous physical activity (MVPA) and obesity have independently been associated with AD. +1 more finding

• Down Syndrome
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Association between periodontal disease and Alzheimer's disease: a scoping review

55/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

Key finding: PD may be a modifiable risk factor for AD, and periodontal interventions could contribute to AD prevention and management. +1 more finding

• Brain Biology
• Prevention

Full summary, score breakdown and related studies → Original source

Intraoperative hypotension and postoperative delirium among older high-risk patients undergoing major noncardiac surgery: a retrospective single-centre cohort study

55/100 ✓ Peer-reviewed Clinical safety BJA Open

Key finding: Although intraoperative hypotension initially appeared to be associated with postoperative delirium, this association was no longer significant when accounting for temporal improvements in perioperative care. +4 more findings

Full summary, score breakdown and related studies → Original source

Linking nutrition and aging: A cross-domain analysis of Mediterranean Diet Adhesion Screener components

38/100 ✓ Peer-reviewed Prevention trials Mechanisms of Ageing and Development

Key finding: This study explores the scientific landscape linking the Mediterranean Diet Adherence Screener (MEDAS) to aging-related health outcomes through a comprehensive bibliometric and scoping review approach. +1 more finding

• Lifestyle

Full summary, score breakdown and related studies → Original source

Automated Speech Markers of Alzheimer Dementia: Test of Cross-Linguistic Generalizability

52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Medical Internet Research

Key finding: In the within-language condition, combined speech timing and lexico-semantic features yielded maximal classification (area under the receiver operating characteristic curve [AUC]=0.88), outperforming single-feature models (AUC=0.79 for timing features; AUC=0.80 for lexico-semantic features). +4 more findings

Full summary, score breakdown and related studies → Original source

Explorando a inibição da bace: uma revisão sistemática dos potenciais tratamentos para a doença de Alzheimer

26/100 ✓ Peer-reviewed Risk genes beyond APOE BioSCIENCE

Key finding: Foram incluídos ensaios clínicos randomizados que avaliaram a eficácia e segurança dos inibidores da BACE1 em pacientes com DA leve a moderada. +4 more findings

Full summary, score breakdown and related studies → Original source

Characterizing the distinct neuroanatomical phenotypes, cognitive profiles, and transcriptomic signatures of brain structural subtypes in Parkinson's disease with mild cognitive impairment

40/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of Disease

Key finding: Subtype 1 (n = 63) features localized supra-normal gray matter volume deviations in dorsolateral prefrontal regions, elevated free water indicating microstructural disruption, executive dysfunction, and transcriptional enrichment in metabolic dysfunction and neurodegenerative pathways. +4 more findings

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes

43/100 ✓ Peer-reviewed Risk factors Frontiers in Endocrinology

Key finding: In this review, we conclude that cognitive impairment in T2D results from complex, interrelated mechanisms requiring early intervention and personalized strategies.

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source