Newest studies

Analyzing heterogeneity in Alzheimer disease using multimodal normative modeling on imaging‐based ATN biomarkers

53/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer s & Dementia

Key finding: Greater intra-group heterogeneity in ATN abnormality patterns was observed in more severe clinical stages of AD. +4 more findings

• Brain Scans
• Biomarkers

Full summary, score breakdown and related studies → Original source

AI approaches for phenotyping Alzheimer's disease and related dementias using electronic health records

40/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: score 0.8323, although only the AUC was statistically significantly different) and other AI-based models. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Prevalence of dementia and mild cognitive impairment among the older prisoner population in England and Wales: a cross-sectional study

45/100 ✓ Peer-reviewed Getting a diagnosis BMJ Open

Key finding: We recruited 596 men and 273 women prisoners. +4 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Translation with ongoing adaptation and improvement (ToAI) framework: A community‐informed, structured, iterative approach to culturally adapting cognitive assessment tools

44/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: The ToAI framework followed a nine-step process: preparation, translation, native-speaker review, VIP team review, external panel review, pilot testing, proofreading, final formatting, and ongoing review and improvement. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Diagnostic value of fluid‐based non‐amyloid biomarkers for Alzheimer's disease and related dementias in a clinic‐based cohort from South Asia

41/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: Our results emphasize the role of fluid biomarkers in diagnosing dementia in low‐resource settings in South Asians. +4 more findings

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Cognitive assessment in hearing aid clinics: Is it feasible to implement in a National Health Service (NHS) setting?

44/100 ✓ Peer-reviewed Getting a diagnosis Science Progress

Key finding: All completed cognitive assessment, average duration was 14 minutes. +4 more findings

• Diagnosis
• Lifestyle

Full summary, score breakdown and related studies → Original source

Feasibility of Telephone‐Based Cognitive Assessments and Healthcare Utilization in US Medicare‐Enrolled Older Adults Following Emergency Department Discharge

41/100 ✓ Peer-reviewed Getting a diagnosis International Journal of Geriatric Psychiatry

Key finding: Twenty-six percent of eligible ED users contacted elected for study enrollment. +4 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Performance of the Brain Health Test-7, Mini-Mental State Examination, and Montreal Cognitive Assessment for detecting subjects with mild cognitive impairment

46/100 ✓ Peer-reviewed Getting a diagnosis International Psychogeriatrics

Key finding: The three cognitive assessment tools were valid for detecting subjects with MCI or dementia according to ROC analysis. +4 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Investigating Brain Lobe Biomarkers to Enhance Dementia Detection Using EEG Data

42/100 ✓ Peer-reviewed Getting a diagnosis Cognitive Computation

Key finding: Dementia is a growing global health concern that significantly impacts the quality of life for millions of individuals and imposes substantial burdens on healthcare systems. +2 more findings

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Ground robot technologies in wildfire risk reduction. The viewpoint of the fire service

37/100 ✓ Peer-reviewed Prevention and risk Progress in Disaster Science

Key finding: Fire service perceives the robot use in wildfire risk reduction more broadly than is reflected by currently developed disaster robots and existing disaster risk reduction concepts.

• Digital Tools
• Prevention

Full summary, score breakdown and related studies → Original source

Climate change and biodiversity in Brazil: What we know, what we don’t, and Paris Agreement’s risk reduction potential

56/100 ✓ Peer-reviewed Prevention and risk Perspectives in Ecology and Conservation

Key finding: We found that climate change impacts on biodiversity vary spatially. +1 more finding

• Prevention

Full summary, score breakdown and related studies → Original source

Real-world safety profile of lecanemab: A disproportionality analysis of adverse events in the FDA adverse event reporting system

38/100 ✓ Peer-reviewed Treatments JAPhA Pharmacotherapy

Key finding: This study underscores the importance of vigilant monitoring for ARIA and other neurologic and psychiatric AEs associated with lecanemab in real-world clinical settings. +3 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

The relationship between neurofilament light chain and depressive symptoms according to cognitive status

50/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: NfL levels were not significantly associated with GDS-15 in a population of community-dwelling older adults without dementia. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Neighborhood disadvantage and the incidence of dementia in US Black women

61/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Age- and education-adjusted hazard ratios (HRs) for ADRD increased as neighborhood disadvantage increased, to 1.42 (95% confidence interval [CI] 1.06-1.91) in the most disadvantaged quintile compared to the least disadvantaged quintile, with a significant linear trend (p = 0.012). +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Trends in the use of advance care planning and cognitive assessment and care planning service visits: moving toward a palliative‐informed approach for ambulatory care of community‐dwelling persons with dementia and their caregivers

42/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: For 2018 and 2019, 3.5% and 5.4% received ACP visits, and 0.4% and 0.5% received CAACPS visits, similar to use reported elsewhere. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers

60/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Among adults with Down syndrome, the striatum consistently accumulates amyloid earlier than the cortex when measured with PiB. +1 more finding

• Down Syndrome
• Brain Scans

Full summary, score breakdown and related studies → Original source

Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease

56/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma p-tau212 might have utility for theragnostics, monitoring therapy efficacy, and as a target engagement biomarker in clinical trials both in sporadic and DSAD.

• Biomarkers
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Protocol for a Randomized Phase II/III Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Extended-Release Metformin in Amnestic Mild Cognitive Impairment: Metformin in Alzheimer Dementia Prevention (MAP)

54/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

Key finding: Observational studies and pilot trials suggest that metformin may help prevent cognitive decline in neurodegenerative disorders. +2 more findings

• Clinical Trials
• Early Stage
• Side Effects

Full summary, score breakdown and related studies → Original source

Molecular pathways and diagnosis in spatially resolved Alzheimer's hippocampal atlas

43/100 ✓ Peer-reviewed Genetics Neuron

Key finding: The transcriptomic map, with single-cell precision, unveiled AD-associated alterations with spatial specificity, which include the following: (1) elevated synapse pruning gene expression in the fimbria of AD, with disrupted microglia-astrocyte communication likely leading to disorganized synaptic structure; (2) a globally increased energy generation in the cornu ammonis (CA) region, with varying degrees across its subregions; (3) a significant reduction in the number of CA1 neurons in AD, while CA4 neurons remained largely unaffected, potentially due to gene alterations in CA4 conferring resilience to AD; and (4) aggravated amyloid-beta (Aβ) plaques in CA1 and stratum lucidum, radiatum, and moleculare (SLRM), and integration of Stereo-seq map with Aβ staining revealed a sequential enrichment of microglia and astrocytes around Aβ plaques.

• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Efficacy and safety of passive immunotherapies targeting amyloid beta in Alzheimer's disease: A systematic review and meta-analysis

90/100 ✓ Peer-reviewed Treatments PLoS medicine

Key finding: Compared with placebo, treatment with mAbs significantly improved cognitive performance on CDR-SB (mean difference -0.25, 95% confidence interval [CI] [-0.38, -0.11]) and ADAS-Cog (standardized mean difference -0.09, 95% CI [-0.12, -0.06]), in which a negative change indicates improvement for both scores. +1 more finding

Full summary, score breakdown and related studies → Original source

Smart monitoring technology to support home-based dementia care: Market-specific business model development and implementation considerations in the Netherlands

36/100 ✓ Peer-reviewed Health systems and care delivery Digital health

Key finding: Our findings add to the limited research on the entrepreneurial side of implementing dementia care technology.

• Digital Tools

Full summary, score breakdown and related studies → Original source

Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals

42/100 ✓ Peer-reviewed Clinical safety Psychiatry and Clinical Neurosciences

Key finding: Sixteen of 30 cases with DLB pathology had no parkinsonism, which represented diverse nigral neurodegeneration. +4 more findings

• Other Dementias
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease

67/100 ✓ Peer-reviewed Disease mechanisms Nature Medicine

Key finding: Across the AD spectrum in three different cohorts (n = 108, 55 and 739), plasma eMTBR-tau243 levels were significantly elevated at the mild cognitive impairment stage and increased further in dementia. +1 more finding

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Late-life affective disorders and risk of progression to dementia: retrospective cohort study of patients in secondary care

53/100 ✓ Peer-reviewed Brain tissue and pathology The British Journal of Psychiatry

Key finding: Some 5695 patients were identified and included in the final analysis. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures

35/100 ✓ Peer-reviewed Brain tissue and pathology Neuron

Key finding: Neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) results from both gain of toxicity and loss of normal function of the RNA-binding protein TDP-43, but their mechanistic connection remains unclear. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source