Newest studies

Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice

43/100 ✓ Peer-reviewed Disease mechanisms International immunopharmacology

Key finding: Oxidative stress and neuroinflammation involved in autophagy are associated with the cerebral ischemia-induced exacerbation of cognitive deficits in individuals with AD. +3 more findings

• Brain Biology
• Digital Tools

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A systematic review of the efficacy and safety of anti-amyloid beta monoclonal antibodies in treatment of Alzheimer's disease

71/100 ✓ Peer-reviewed Treatments Expert opinion on biological therapy

Key finding: According to CDR-SB measurements, lecanemab showed effectiveness in reducing brain amyloid and cognitive decline, with a change from baseline of 1.21. +4 more findings

• Treatments

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Detecting functional impairment with the Digital Clock and Recall

43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD

Key finding: The DCR scaled well with FAQ scores, and ML classifiers trained on multimodal DCR features demonstrated strong performance in predicting functional impairment on a held-out test set. +2 more findings

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Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability

74/100 ✓ Peer-reviewed Biomarkers Nature aging

Key finding: Individual-level interpretation of diagnostic test results requires knowledge of disease prevalence in relation to clinical presentation (clinical pretest probability). +3 more findings

• Biomarkers
• Treatments
• Diagnosis

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APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia

43/100 ✓ Peer-reviewed Genetics EMBO molecular medicine

Key finding: We express here the human APOE isoforms in astrocytes in an Apoe-deficient AD mouse model. +4 more findings

• Genetics
• Brain Biology

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Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

43/100 ✓ Peer-reviewed Genetics Cell

Key finding: In human neurons, the addition of ApoE carrying polyunsaturated fatty acids (PUFAs)-CE revealed an allelic series (ApoE4 > ApoE3 > ApoE2) associated with lipofuscinosis, an age-related lysosomal pathology resulting from lipid peroxidation.

• Genetics
• Brain Biology

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Sex differences in the association between repetitive negative thinking and neurofilament light

43/100 ✓ Peer-reviewed Biomarkers Npj mental health research

Key finding: Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer's disease. +3 more findings

• Biomarkers

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Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease

48/100 ✓ Peer-reviewed Digital health tools Nature neuroscience

Key finding: Here we performed single-nucleus RNA sequencing of 628,943 astrocytes from five brain regions representing the stereotypical progression of AD pathology across 32 donors spanning the entire normal aging to severe AD continuum. +4 more findings

• Brain Biology

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Use of Augmentative and Alternative Communication Technology to Retrain Attention and Enhance Functional Communication Following Severe Traumatic Brain Injury: A Clinical Case Report

29/100 ✓ Peer-reviewed Health systems and care delivery Perspectives of the ASHA Special Interest Groups

Key finding: Through systematic instruction and retraining visual and sustained attention, the patient was able to engage meaningfully with a high-tech device to increase functional personal choice when supported by a partner. +1 more finding

• Digital Tools
• Risk Factors

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Genetic variants for Alzheimer's disease and comorbid conditions

70/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease : JAD

Key finding: Targeted analysis of 20 SNPs that were reported to be associated with ADRD revealed that six were significantly associated with dual-disease outcomes, specifically congestive heart failure and cancer. +3 more findings

• Genetics

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The Amyloid Cascade Hypothesis: A Conclusion in Search of Support

46/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The American journal of pathology

Key finding: Assuming these findings hold, it appears that Aβ neither drives nor mitigates the disease process.

• Genetics
• Brain Biology

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Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology

66/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma phosphorylated Tau 181 (pTau181) and CSF chitinase-3-like protein 1 (YKL-40) increased following semorinemab treatment in both studies. +4 more findings

• Biomarkers
• Clinical Trials

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Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders

59/100 ✓ Peer-reviewed Biomarkers Journal of the neurological sciences

Key finding: Plasma GFAP levels were significantly (all p < 0.001) elevated in bvFTD (n = 22, mean (M) = 273 pg/mL) compared to BPAD (n = 121, M = 96 pg/mL), MDD (n = 42, M = 105 pg/mL), TRS (n = 82, M = 67.9 pg/mL), and HC (n = 120, M = 76.8 pg/mL). +4 more findings

• Biomarkers

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Lithium: Fifteen Years Later

43/100 ✓ Peer-reviewed Drug development Neuropsychobiology

Key finding: The 75th anniversary of introducing lithium into modern psychiatry is recognized, attested by the 1949 paper of John Cade. +2 more findings

• Treatments

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Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer's diseases

43/100 ✓ Peer-reviewed Drug development IBRO neuroscience reports

Key finding: We found that the AL04 treatment decreases hyperphosphorylated tau at PP2A-sensitive epitope Ser202/Thr205 in the hippocampus of the brain. +3 more findings

• Treatments

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Automated Volumetric Software in Dementia: Help or Hindrance to the Neuroradiologist?

48/100 ✓ Peer-reviewed Brain scans and imaging AJNR. American journal of neuroradiology

Key finding: There was no statistically significant effect of the report on overall correct diagnoses. +4 more findings

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Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors

43/100 ✓ Peer-reviewed Risk genes beyond APOE International journal of molecular sciences

Key finding: In AD, the haploinsufficiency of genes such as ABCA7 and SORL1 may play significant yet under-explored roles. +1 more finding

• Genetics
• Brain Biology

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A comprehensive evaluation on the associations between hearing and vision impairments and risk of all-cause and cause-specific dementia: results from cohort study, meta-analysis and Mendelian randomization study

66/100 ✓ Peer-reviewed Prevention and risk BMC Medicine

Key finding: Our findings showed significant associations between hearing and vision impairments and increased risks of all-cause and cause-specific dementia. +4 more findings

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Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis

45/100 ✓ Peer-reviewed Disease mechanisms Cell Metabolism

Key finding: Using the 5xFAD mouse model, we identify increased Clostridium abundance and decreased Bacteroides abundance as key features associated with β-amyloid (Aβ) burden. +2 more findings

• Brain Biology

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Implementing palliative and end of life care for people with dementia

43/100 ✓ Peer-reviewed End-of-life care Nursing older people

Key finding: Dementia is characterised by memory loss, behavioural changes and decline of cognitive, social and physical functions and is a life-limiting condition. +4 more findings

• End-of-Life Care

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A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice

43/100 ✓ Peer-reviewed Drug development Redox biology

Key finding: Transcriptome sequencing revealed increased expression of mitochondrial respiratory chain complex proteins in the brains of APP/PS1 mice after Givinostat treatment.

• Treatments
• Brain Biology
• Digital Tools

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Perspectives of municipal professionals on adopting a dementia-friendly and inclusive approach in urban planning and design in British Columbia, Canada

33/100 ✓ Peer-reviewed Health systems and care delivery Planning Practice and Research

Key finding: Municipalities in British Columbia (B.C.), Canada have committed to the vision of DFCs with action plans outlining priorities in planning, design, engineering, and services. +4 more findings

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Neuroinflammatory Biomarkers in Alzheimer's Disease: From Pathophysiology to Clinical Implications

47/100 ✓ Peer-reviewed TREM2 and immune genetics International journal of molecular sciences

Key finding: The neuroinflammatory fluid biomarkers GFAP, sTREM2, and YKL-40 have gained attention for their potential in early detection and monitoring of disease progression. +3 more findings

• Biomarkers
• Brain Biology

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AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer's disease mice

44/100 ✓ Peer-reviewed Genetics Molecular Therapy

Key finding: We tested the hypothesis that AAVrh.10-mediated CNS delivery of the human APOE2 allele with the Christchurch mutation (R136S) (E2Ch) will provide superior protection against APOE4-associated Alzheimer's disease (AD) in mice compared to the unmodified APOE2 allele (E2). +1 more finding

• Brain Biology
• Genetics

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Trace Lithium for Suicide Prevention and Dementia Prevention: A Qualitative Review

71/100 ✓ Peer-reviewed Drug development Pharmaceuticals (Basel, Switzerland)

Key finding: While most studies to date have been cross-sectional, limiting the establishment of causal relationships, the potential benefits of trace lithium for suicide prevention and dementia prevention are notable, especially in the absence of radical treatments for suicide and dementia. +4 more findings

• Treatments
• Prevention

Full summary, score breakdown and related studies → Original source