Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,901–7,925 of 27,380 studies, newest first · page 317 of 1096.
March 2023 18
-
2023-03-02
Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40
45/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Most participants were cognitively normal (427 of 491 [87%]) and the mean age was 69.0 ± 8.8 years. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-02
Effectiveness of non-pharmacological therapies on cognitive function in patients with dementia-A network meta-analysis of randomized controlled trials
78/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in aging neuroscience
Key finding: In this study, NPTs have excellent potential to improve cognition in people with dementia, and PBM may have more significant benefits in improving cognition than the other four NPTs. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-02
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
51/100 ✓ Peer-reviewed TREM2 and immune genetics Cancer cell
Key finding: Physiologically, neutrophils are known to have a short half-life. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders
43/100 ✓ Peer-reviewed Risk factors Human & Experimental Toxicology
Key finding: Recent extensive evidence suggests that ambient fine particulate matter (PM2.5, with an aerodynamic diameter ≤2.5 μm) may be neurotoxic to the brain and cause central nervous system damage, contributing to neurodevelopmental disorders, such as autism spectrum disorders, neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and mental disorders, such as schizophrenia, depression, and bipolar disorder. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03 month only
β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats
41/100 ✓ Peer-reviewed Inflammation and the immune system Neural regeneration research
Key finding: β2-Microglobulin (β2M), a component of the major histocompatibility complex class I molecule, is associated with aging-related cognitive impairment and Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03 month only
Acceptability and feasibility of plasma phosphorylated-tau181 in two memory services
41/100 ✓ Peer-reviewed Biomarkers International journal of geriatric psychiatry
Key finding: Twenty-nine participants' plasma p-tau181 samples were included (mean age 74 SD 8.5, 65% female). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Lecanemab: First Approval
40/100 ✓ Peer-reviewed Treatments Drugs
Key finding: It is being developed by Eisai, under a global licence from BioArctic (formerly BioArctic Neuroscience), and in collaboration with Biogen, for the treatment of Alzheimer's disease, and received its first approval for this indication on 6 January 2023 in the USA under the Accelerated Approval Pathway. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Anti-amyloid antibody therapies in Alzheimer's disease
43/100 ✓ Peer-reviewed Treatments Brain : a journal of neurology
Key finding: In addition to meeting the primary outcome of slowing clinical disease progression over 18 months, secondary clinical outcomes and amyloid-β lowering on PET also underpin the positive results of the trial. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Plasma biomarker profiles in autosomal dominant Alzheimer's disease
71/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology
Key finding: Here we aimed to explore the timing and performance of plasma biomarkers in mutation carriers compared to non-carriers in autosomal dominant Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration
62/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology
Key finding: Recent studies suggest that blood total-tau originates principally from peripheral, non-brain sources. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound
43/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology
Key finding: Whole brain vertex-based analysis of the 18F-florbetaben PET imaging demonstrated clusters of modest SUVR reduction in the right parahippocampal and inferior temporal lobe.
Full summary, score breakdown and related studies → Original source
-
2023-03-01
The impact of the mySupport advance care planning intervention on family caregivers' perceptions of decision-making and care for nursing home residents with dementia: pretest-posttest study in six countries
43/100 ✓ Peer-reviewed End-of-life care Age and ageing
Key finding: Family caregivers of nursing home residents with dementia received an educational booklet and a family care conference with a trained facilitator to discuss their relative's future care. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Social Determinants of Health and Traumatic Brain Injury: Implications for Rehabilitation Service Delivery and Outcomes
34/100 ✓ Peer-reviewed Risk factors Journal of Head Trauma Rehabilitation
Key finding: Taken together, findings weave a relatively cohesive narrative: recovery from TBI is inextricably connected to social forces, and such forces warrant increased attention in TBI care and research. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
A population-based retrospective cohort study of end-of-life emergency department visits by people with dementia: multilevel modelling of individual- and service-level factors using linked data
51/100 ✓ Peer-reviewed Health systems and care delivery Age and Ageing
Key finding: of 74,486 decedents (60.5% women; mean age 87.1 years (standard deviation: 7.1)), 82.6% had at least one ED visit in their last year of life. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment
48/100 ✓ Peer-reviewed TREM2 and immune genetics Brain : a journal of neurology
Key finding: Ozone (O3) is a reactive gas component of air pollution linked to increased AD risk, but is confined to the respiratory tract after inhalation, implicating the peripheral immune response to air pollution in AD neuropathology. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
56/100 ✓ Peer-reviewed Risk factors Cell death & disease
Key finding: Abnormal forms of α-syn trigger selective and progressive neuronal death through mitochondrial impairment, lysosomal dysfunction, and alteration of calcium homeostasis not only in PD but also in other α-syn-related neurodegenerative disorders such as dementia with Lewy bodies, multiple system atrophy, pure autonomic failure, and REM sleep behavior disorder. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2023-03-01
Lecanemab reduces brain amyloid-β and delays cognitive worsening
47/100 ✓ Peer-reviewed Treatments Cell reports. Medicine
Key finding: Lecanemab cleared amyloid-β in two-thirds and reduced the rate of cognitive and functional worsening in people with mild cognitive impairment and mild dementia due to Alzheimer disease in an 18-month double-blinded randomized placebo-controlled trial reported by van Dyck et al.
Full summary, score breakdown and related studies → Original source
-
2023-03-01
TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study
51/100 ✓ Peer-reviewed Biomarkers The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: After adjusting for confounders, Aβ 42/40 was not associated with nutritional or inflammatory markers. +2 more findings
Full summary, score breakdown and related studies → Original source
February 2023 7
-
2023-02-28
The β-adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry
Key finding: EE also suppresses neuroinflammation, suggesting that β2 -AR agonists may play a neuroprotective role.
Full summary, score breakdown and related studies → Original source
-
2023-02-28
Brain reserve contributes to distinguishing preclinical Alzheimer's stages 1 and 2
57/100 ✓ Peer-reviewed Risk factors Alzheimer's research & therapy
Key finding: In asymptomatic individuals, brain volumes of hippocampal subfields and of the parahippocampal cortex were numerically larger in stage 1 compared to HCs, whereas the opposite was the case in individuals with SCD. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2023-02-28
Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects
41/100 ✓ Peer-reviewed Drug development Inflammopharmacology
Key finding: Evidence from clinical trial studies revealed the little effect of metformin on AD. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2023-02-28
The association of MIND diet with cognitive resilience to neuropathologies
59/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The MIND diet is associated with both higher cognition and slower rates of cognitive decline, after controlling for neuropathology, indicating the MIND diet may be important to cognitive resilience. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2023-02-28
Masitinib for mild-to-moderate Alzheimer's disease: results from a randomized, placebo-controlled, phase 3, clinical trial
76/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy
Key finding: Masitinib is an orally administered tyrosine kinase inhibitor that targets activated cells of the neuroimmune system (mast cells and microglia). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2023-02-28
Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease
47/100 ✓ Peer-reviewed Drug development Expert opinion on investigational drugs
Key finding: Nearly a dozen monoclonal antibodies (mAbs) directed against beta-amyloid (Aβ) have been developed for the treatment of Alzheimer disease (AD), and most of these mAbs are undergoing clinical trials. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2023-02-27
Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments
41/100 ✓ Peer-reviewed Vascular contributions Stroke
Key finding: The endothelium is regulated by perivascular cells and components forming the neurovascular unit. +4 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →