Newest studies

Evaluating the feasibility of a community-adapted multi-domain intervention for dementia prevention in older adults

38/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer s Disease

Key finding: Additionally, health outcomes, including cognitive function and overall lifestyle, were evaluated. +2 more findings

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Relationships Among Caregiver Burden, Psychological Flexibility Processes, and Anxiety in Family Caregivers of People with Dementia

41/100 ✓ Peer-reviewed Caregiving Clinical Gerontologist

Key finding: Caregiver burden had a significant direct effect on anxiety (59.1% of the total effect), while indirect effects accounted for 40.9%. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Enlarged perivascular spaces correlate with blood-brain barrier leakage and cognitive impairment in Alzheimer's disease

45/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer s Disease

Key finding: Finally, the relationship between CSO BBB permeability and cognition in AD patients was investigated. +1 more finding

• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Demographic Analysis of Occupational Safety in the Construction Sector: Strategies and Insights for Risk Reduction

36/100 ✓ Peer-reviewed Prevention and risk Buildings

Key finding: The construction sector is among the most dangerous industries, recognized for its significant rate of accidents with even more serious consequences, especially in developing countries. +2 more findings

• Prevention
• Side Effects

Full summary, score breakdown and related studies → Original source

The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study

58/100 ✓ Peer-reviewed Long-term cohort studies Molecular Psychiatry

Key finding: Late-life depression (LLD) has been linked to increased likelihood of dementia, although mechanisms responsible for this association remain largely unknown. +2 more findings

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Normal pressure hydrocephalus combined with quadruple misfolded proteinopathy: An autopsy case report and a short review of literature

47/100 ✓ Peer-reviewed Tau biomarkers Journal of Neuropathology & Experimental Neurology

Key finding: There are many reports about the comorbidity of NPH and other neurodegenerative diseases1–3; the primary findings in neuropathological studies of patients with NPH include amyloid plaques and hyperphosphorylated tau protein inclusions.2,4 This suggests that proteinopathy may be one of the potential causes of NPH. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Muscone enhances synaptic function in vascular dementia through activating BDNF-TrkB-NP2 signaling pathway

37/100 ✓ Peer-reviewed Lewy body dementia International Immunopharmacology

Key finding: • To clarify the key role of Muscone delayed the development of vascular dementia (VD). • To reveal synaptic function in VD associated with neuronal pentraxin receptor (NP2). • To reveal that Muscone alleviates VD through the BDNF-TrkB-NP2 signaling pathway initially. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Targeting Amyloid Pathology in Early Alzheimer's: The Promise of Donanemab-Azbt

43/100 ✓ Peer-reviewed Treatments Pharmacy (Basel, Switzerland)

Key finding: Key results included a 35% slowing of decline on the Integrated Alzheimer's Disease Rating Scale (iADRS) and a 36% slowing on the Clinical Dementia Rating-Sum of Boxes (CDR-SB). +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer’s Disease

35/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroimmune Pharmacology

Key finding: The data suggest that TNFSF10 system-targeted treatment effectively restrain overshooting central and peripheral inflammation by rebalancing the overall immune response, mitigating the progression of AD pathology. +3 more findings

• Brain Biology

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Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia

41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Ethnopharmacology

Key finding: LAPs improved cognitive function and increased the number of Nissl bodies, lactate secretion, the IL-10 content, the relative fluorescence intensity of the IBA1 and AXL proteins, and the protein expression levels of AXL, Mertk, Glut1, HK2, PI3K, p-Akt/Akt, p-mTOR/mTOR and HIF-1α of immune-tolerant AD mice. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of Rheumatoid Arthritis With Progression of Cognitive Impairment and Risk of Mortality in People With Dementia

54/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology

Key finding: We identified a worse cognitive function and an increased mortality risk in dementia patients with RA compared with non-RA. +2 more findings

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Nomogram for predicting changes in cognitive function in community dwelling older adults with mild cognitive impairment based on Korea Longitudinal Study of Ageing Panel Data: a retrospective study

50/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Korean Academy of Nursing

Key finding: The rate of reversion from MCI to normal cognition was 37.0% after 2 years and 32.9% after 12 years. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Understanding basic and social emotions in Alzheimer's disease and frontotemporal dementia

41/100 ✓ Peer-reviewed Lewy body dementia Frontiers in Psychology

Key finding: FTD patients performed significantly worse than HCs in most of the subtests of the basic emotion recognition batteries, where, instead, AD patients were significantly impaired only when required to match emotional facial expression in different individuals (subtask of the FERB). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults

65/100 ✓ Peer-reviewed Risk factors BMC Public Health

Key finding: Over a mean follow-up of 7.9 years, 694 incident dementia cases occurred. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study

44/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: • CircS was associated with a 40.1 % increased risk of incident all-cause dementia. • A graded increase in dementia risk with escalating severity of CircS. • The presence of ≥ 3 CircS components was significantly associated with dementia. • There was a synergistic effect of CircS and high genetic risk on dementia. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals

64/100 ✓ Peer-reviewed Caregiving JAMA Network Open

Key finding: Among 5390 participants (mean [SD] age, 76.9 [4.8] years; 2915 women [54.1%]), there were 2655 individuals (49.3%) with less than 12 years of education. +4 more findings

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Prevalence of Post-stroke Cognitive Impairment and Dementia in a Sudanese Cohort: A Single-center Retrospective Study

38/100 ✓ Peer-reviewed Getting a diagnosis International Journal of Biochemistry Research & Review

Key finding: Of 81 stroke survivors (mean age 61.9±13.9 years), 72.8% had ischemic stroke, and 27.2% had hemorrhagic stroke. +4 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Association Between Lifestyle at Different Life Periods and Brain Integrity in Older Adults

68/100 ✓ Peer-reviewed Treatments Neurology

Key finding: In 135 older adults (mean age = 69.3 years; women = 61.5%), no associations were found within AD-signature regions (all p > 0.25). +2 more findings

• Clinical Trials
• Brain Scans
• Lifestyle

Full summary, score breakdown and related studies → Original source

ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression

50/100 ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology

Key finding: ALS plasma showed elevation of the established biomarkers, neurofilament light chain (NEFL) and neurofilament heavy chain (NEFH). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Association of metabolic dysfunction‐associated fatty liver disease with white matter hyperintensity and cognitive decline: A longitudinal cohort study

49/100 ✓ Peer-reviewed Vascular contributions Diabetes Obesity and Metabolism

Key finding: MAFLD was associated with an increased risk of WMH over 4.1 years in middle‐aged adults. +4 more findings

• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Synaptosomal‐Associated Protein 25 kDA (SNAP‐25) Levels in Cerebrospinal Fluid: Implications for Alzheimer's Disease Diagnosis and Monitoring

49/100 ✓ Peer-reviewed Disease mechanisms Synapse

Key finding: CSF SNAP-25 concentration was higher in AD and non-neurodegenerative diseases (i.e., vascular dementia) compared with controls but did not differ between AD and non-AD neurodegenerative diseases. +4 more findings

• Biomarkers
• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

The Role of Gut Microbiota-Derived Trimethylamine N-Oxide in the Pathogenesis and Treatment of Mild Cognitive Impairment

43/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Molecular Sciences

Key finding: Emerging evidence has demonstrated a strong association between trimethylamine-N-oxide (TMAO), a prominent metabolite derived from the gut microbiota, and MCI, highlighting its potential as a biomarker and therapeutic target.

• Early Stage
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Frontotemporal dementia. How to deal with its diagnostic complexity?

43/100 ✓ Peer-reviewed Lewy body dementia Expert Review of Neurotherapeutics

Key finding: Frontotemporal dementia (FTD) encompasses a group of heterogeneous neurodegenerative disorders. +4 more findings

• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Who Are Midlife Women Family Caregivers With Negative Attitudes Toward Alzheimer’s Disease and Dementia Care?

38/100 ✓ Peer-reviewed Caregiving Western Journal of Nursing Research

Key finding: Participants' attitude toward Alzheimer's disease and related dementia scores were significantly associated with employment status, race/ethnicity (Hispanic), and instrumental activities of daily living. +2 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Unraveling the subjective well-being of formal and informal caregivers for people with dementia: a comparative analysis

44/100 ✓ Peer-reviewed Caregiving BMC Geriatrics

Key finding: Formal caregivers exhibited significantly better psychological well-being and self-rated health compared to informal caregivers. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source