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Mediation of modifiable risk factors in two multidomain dementia prevention trials
Marieke P. Hoevenaar‐Blom, Jason Shourik, Jan Willem van Dalen, Willem A. van Gool, Sandrine Andrieu, Edo Richard, Nicola Coley, Eric Moll van Charante et al.. Alzheimer s & Dementia, 2025-01-27
Topic: Risk, prevention and care in population studies
Plain-language summary
We observed no mediation of individual risk factors in the effect of the interventions on dementia incidence. The interventions slightly lowered only blood pressure, but this did not translate into an effect on dementia incidence. In older populations, multidomain interventions may not sufficiently affect dementia risk factors to lower dementia incidence, particularly in settings where cardiovascular risk factor management is well implemented. HIGHLIGHTS: There is no mediating role of risk factor change in the effects of multidomain interventions on dementia incidence in two large dementia prevention randomized controlled trials. The lack of effect of the interventions on risk factors explains the absence of impact on dementia. Counteracting mediators do not explain the lack of effect of the interventions on dementia. A small effect of the interventions on blood pressure did not translate into a lower dementia incidence.
What this study adds
Evidence grade: High
The record lists 1,679 participants. In these two large prevention trials, the interventions did not lower dementia incidence, and changes in individual risk factors did not explain the results. The interventions slightly lowered only blood pressure, but this did not translate into less dementia.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Hoevenaar‐Blom, M. P., Shourik, J., van Dalen, J. W., van Gool, W. A., Andrieu, S., Richard, E., et al. (2025). Mediation of modifiable risk factors in two multidomain dementia prevention trials. Alzheimer s & Dementia. https://doi.org/10.1002/alz.14557
Vancouver
Hoevenaar‐Blom MP, Shourik J, van Dalen JW, van Gool WA, Andrieu S, Richard E, et al. Mediation of modifiable risk factors in two multidomain dementia prevention trials. Alzheimer s & Dementia. 2025. doi:10.1002/alz.14557. PMID: 39868821.
BibTeX
@article{hoevenaarblom2025-39868821,
author = {Hoevenaar‐Blom, Marieke P. and Shourik, Jason and van Dalen, Jan Willem and van Gool, Willem A. and Andrieu, Sandrine and Richard, Edo and Coley, Nicola and van Charante, Eric Moll and others},
title = {{Mediation of modifiable risk factors in two multidomain dementia prevention trials}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.14557},
pmid = {39868821},
url = {https://doi.org/10.1002/alz.14557}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- We observed no mediation of individual risk factors in the effect of the interventions on dementia incidence.
- The interventions slightly lowered only blood pressure, but this did not translate into an effect on dementia incidence.
- In older populations, multidomain interventions may not sufficiently affect dementia risk factors to lower dementia incidence, particularly in settings where cardiovascular risk factor management is well implemented.
- HIGHLIGHTS: There is no mediating role of risk factor change in the effects of multidomain interventions on dementia incidence in two large dementia prevention randomized controlled trials.
- The lack of effect of the interventions on risk factors explains the absence of impact on dementia.
Why it matters
In these two large prevention trials, the interventions did not lower dementia incidence, and changes in individual risk factors did not explain the results. The interventions slightly lowered only blood pressure, but this did not translate into less dementia.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Participants1,679
- Evidence strengthHigh
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 45 of the 96 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,679 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39868821) |
| Free to read | 2 / 2 | Free to read |
| Points | 45 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 45 of the 96 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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