Newest studies

Neurovascular Decoupling Is Associated With Lobar Intracerebral Hemorrhages and White Matter Hyperintensities

47/100 ✓ Peer-reviewed Vascular contributions Journal of the American Heart Association

Key finding: This raises the suggestion that a decreased neurovascular coupling in the disease process of AD is related to comorbid small vessel disease. +1 more finding

• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Mechanistic Insights into the Inhibitory and Destabilizing Effects of K353 Acetylation on Tau Peptides and Protofibrils

37/100 ✓ Peer-reviewed Disease mechanisms The Journal of Physical Chemistry B

Key finding: AD is the most common type of dementia associated with aging, and CTE is a special tauopathy that mostly affects contact sports athletes (such as those active in American football and boxing). +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

A New Computer-Based Cognitive Measure for Early Detection of Dementia Risk (Japan Cognitive Function Test): Validation Study

53/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of medical Internet research

Key finding: Significant hazard ratios (HRs) for dementia incidence were found using the MMSE cutoff between 23 and 24 point (HR 1.93, 95% CI 1.13-3.27) and the J-Cog cutoff between 43 and 44 points (HR 2.42, 95% CI 1.50-3.93). +3 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Engaging Health and Aged Care Workers in Rural and Remote Australia Around Factors Impacting Their Access to and Participation in Dementia Training

35/100 ✓ Peer-reviewed Disparities Geriatrics

Key finding: Commonalities emerged in barriers for accessing dementia training. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

ALZENET: Deep learning-based early prediction of Alzheimer's disease through magnetic resonance imaging analysis

48/100 ✓ Peer-reviewed Brain scans and imaging Telematics and Informatics Reports

Key finding: It generally occurs in people aged over 65, and currently, there are around 55 million Alzheimer's patients which is becoming a growing concern, and the death rate due to AD has increased significantly. +2 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Montreal Cognitive Assessment vs the Mini-Mental State Examination as a Screening Tool for Patients With Genetic Frontotemporal Dementia

62/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: < 0.001] total scores differed significantly between groups, with controls (median MoCA 28.5, 95% CI 28.0-29.0; median MMSE 30, 95% CI 30.0-30.0) outperforming prodromal (median MoCA 26, 95% CI 23.0-27.0; median MMSE 29, 95% CI 27.5-29.5) and symptomatic (median MoCA 20.5, 95% CI 17.0-24.0; median MMSE 26, 95% CI 23.5-29.0) carriers. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Childhood Lifestyle Behaviors and Mental Health Symptoms in Adolescence

60/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: Altogether, 187 adolescents (97 boys [51.9%]; mean age, 15.8 [0.4] years) had valid data on self-reported lifestyle behaviors, and 170 adolescents had valid data on device-assessed lifestyle behaviors. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control

43/100 ✓ Peer-reviewed Disease mechanisms The Journal of experimental medicine

Key finding: Here, we found that microglia-specific deletion of Atg7 in an AD mouse model impaired microglia coverage of Aβ plaques, increasing plaque diffusion and neurotoxicity. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Acceptance of Unsupervised App-Based Cognitive Assessment in Outpatient Care: An Implementation Study

50/100 ✓ Peer-reviewed Cognitive tests and assessment JMIR formative research

Key finding: We received completed questionnaires from physicians for 45 patients. +4 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

‘Getting Everyone on the Same Page’: Long‐Term‐Care Nurses' Experiences With Advance Care Planning

30/100 ✓ Peer-reviewed End-of-life care International Journal of Older People Nursing

Key finding: The basic social process that emerged from the data was that of nurses trying to identify an ACP level and craft a corresponding care plan that they believed would optimise residents' comfort in LTC during both acute medical events and at the end-of-life (EOL). +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Nurses’ usage of validated tools to assess for delirium in general acute care settings: A scoping review protocol

29/100 ✓ Peer-reviewed Clinical safety HRB Open Research

Key finding: The PRISMA-ScR flow diagram will present the results of the search. +4 more findings

Full summary, score breakdown and related studies → Original source

Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence

49/100 ✓ Peer-reviewed Disease mechanisms Metabolites

Key finding: They remain a significant focus of scientific and clinical interest due to their increasing medical and social importance. +1 more finding

Full summary, score breakdown and related studies → Original source

Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study

46/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: Over a median follow-up period of 10.44 years, 725 participants developed incident dementia. +4 more findings

• Risk Factors
• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

Machine learning to predict dementia for American Indian and Alaska native peoples: a retrospective cohort study

48/100 ✓ Peer-reviewed How common it is The Lancet Regional Health - Americas

Key finding: The study cohort included 17,398 AI/AN adults aged ≥ 65 years who were dementia-free at baseline, of whom 59.8% were female. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Effect of Initiation and Continuous Adherence to ARBs Versus ACEIs on Risk of Adjudicated Mild Cognitive Impairment or Dementia

55/100 ✓ Peer-reviewed Disparities The Journals of Gerontology Series A

Key finding: Of 9,361 SPRINT participants (mean age 67.1 ± 9.5 years, 36.7% female, 58.7% non-Hispanic White), 710 and 1,289 were new users of an ARB or ACEI. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Caring for People With Dementia: Mapping the Experience and Journey From Diagnosis

50/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Data indicated that participants' needs fluctuated, with 3 key time points of heightened need: dementia diagnosis, in-home care, and transition into residential care. +2 more findings

• Caregiving
• Diagnosis

Full summary, score breakdown and related studies → Original source

Development and validation of the Montreal Cognitive Assessment for People with Vision Impairment (MOCA-VI)

48/100 ✓ Peer-reviewed Getting a diagnosis Psychological Assessment

Key finding: With the optimal item set, the final MoCA-VI had an area under the curve of 0.96 (95% CI [0.93, 0.99]). +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia

44/100 ✓ Peer-reviewed Biomarkers Alzheimer s Research & Therapy

Key finding: and amyloid composite in the context of AD. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer's disease variants

50/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging

Key finding: The aAD patients showed significantly higher tau accumulation, relative hypoperfusion and grey matter density loss in the temporal lobes compared to PCA and lvPPA patients. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice

45/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Pharmacology and Experimental Therapeutics

Key finding: Similar to studies with different inhibitors of Aβ synthesis, we found that 28 days of once-daily oral treatment with the GSM AZ4126 (100 μmol/kg) resulted in a strong reduction in plaque formation and plaque growth. +2 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease

38/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: Based on the fusion of the topological features of the multimodal FBN and SBN, the accuracy for the diagnosis of MCI in patients with unilateral MCA steno-occlusive disease reached 90.00%. +3 more findings

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Identifying pathways to the prevention of dementia: the Netherlands consortium of dementia cohorts

54/100 ✓ Peer-reviewed How common it is BMC Neurology

Key finding: We increased the findability, accessibility, interoperability and reusability (FAIR) status of the cohorts through harmonization of data across cohorts, implementation of medical imaging repositories for scan management, implementation of the Personal Health Train infrastructure and provision of meta-data in existing cohort catalogues. +4 more findings

Full summary, score breakdown and related studies → Original source

Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study

42/100 ✓ Peer-reviewed Disparities npj Science of Food

Key finding: BRBs significantly decreased inflammatory markers, improved oxidative index, and adiponectin (p < 0.05) compared to the placebo group, while adenosine monophosphate-activated protein kinase (AMPK) and leptin did not significantly change. +2 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo

44/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Aging Neuroscience

Key finding: Among the 45 individuals with dementia, mixed dementia had the highest prevalence (42.4%), followed by AD-only (24.4%), non-AD other dementia (22.2%), and non-AD vascular dementia subtypes (11.1%). +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Interpreter Communication Quality in Cognitive Assessments for Dementia

52/100 ✓ Peer-reviewed Getting a diagnosis JAMA Network Open

Key finding: At baseline, there were 126 participants (106 [84.1%] women); mean (SD) age was 44.13 (12.71) years, mean years of interpreting experience was 8.57 (8.48) years, and 106 of 120 (88.3%) lived in an urban area. +4 more findings

• Diagnosis
• Clinical Trials

Full summary, score breakdown and related studies → Original source