Newest studies

Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor

33/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s Research & Therapy

Key finding: We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in design, data analysis, and publication of results for this and other lifestyle intervention studies.

• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Altered Default Mode Network Connectivity in Mild Cognitive Impairment: Insights from Resting-State fMRI Studies

33/100 ✓ Peer-reviewed Mild cognitive impairment Current Alzheimer Research

Key finding: Investigating the DMN using rs-fMRI in individuals with MCI allows researchers to identify early neural changes associated with cognitive decline, which may serve as biomarkers for the early detection of Alzheimer's disease or related dementias. +1 more finding

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Tau‐related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is influenced by Aβ

38/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: We found cortical regions where a reduced glucose metabolism was maximally correlated with distributed patterns of tau, accounting for the effect of Aβ and APOE ε4 genotype. +4 more findings

• Genetics
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Posterior cingulate cortex microRNA dysregulation differentiates cognitive resilience, mild cognitive impairment, and Alzheimer's disease

41/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: We identified specific miRNA groups, mRNA targets, and signaling pathways distinguishing AD, MCI, resilience, ante mortem neuropsychological test performance, post mortem neuropathological burden, and AD risk. +4 more findings

• Early Stage

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Prevalence of subjective cognitive decline and its association with physical health problems among urban community dwelling elderly population in South India

57/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: Among the participants, 377 (93.5%) reported subjective memory complaints. +4 more findings

• Early Stage
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Parallel changes in cognition, neuropsychiatric symptoms, and amyloid in cognitively unimpaired older adults and those with mild cognitive impairment

55/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: NPS was longitudinally associated with performance in each cognitive domain. +4 more findings

• Early Stage

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Tracer kinetic model detecting heterogeneous blood–brain barrier permeability to water and contrast agent in Alzheimer's disease and dementia with Lewy bodies

42/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: AD patients exhibited a significant reduction in the water exchange rates across the BBB, whereas DLB patients showed a significant increase in BBB permeability to contrast agent. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation

37/100 ✓ Peer-reviewed Lewy body dementia CNS Neuroscience & Therapeutics

Key finding: In this review, we outline the significant roles of necroptosis and its molecular mechanisms in the pathological process of VaD, with a particular focus on the role of necroptosis in modulating neuroinflammation and exacerbating the disruption of BBB permeability in VaD, and elaborate on the molecular regulatory mechanisms and the centrally involved cells of necroptosis mediated by tumor necrosis factor-α in neuroinflammation in VaD. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cholinergic degeneration and early cognitive signs in prodromal Lewy body dementia

48/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: cBF volume declined at comparable rates in iRBD-to-PD and iRBD-to-DLB converters, but atrophy was more severe at DLB phenoconversion. cBF atrophy correlated with attention, executive, and memory deficits. +4 more findings

• Other Dementias
• Early Stage

Full summary, score breakdown and related studies → Original source

Loneliness and social isolation correlate with multiple modifiable risk factors for chronic diseases including dementia

48/100 ✓ Peer-reviewed Risk factors Journal of Public Health

Key finding: The direct associations identified may present potential intervention targets, while the indirect relationships suggest that other factors are influential in the pathway linking social isolation and loneliness with chronic disease and dementia. +4 more findings

• Lifestyle
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Enhanced in silico QSAR-based screening of butyrylcholinesterase inhibitors using multi-feature selection and machine learning

34/100 ✓ Peer-reviewed Digital health tools SAR and QSAR in environmental research

Key finding: After integrating HIA data with existing machine learning algorithms, we observed a significant reduction of 89.63% in the number of inhibitors.

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study

52/100 ✓ Peer-reviewed Digital health tools BMJ Open

Key finding: 11 variables were critical in the training phase, including educational level, depression, insomnia, age, Body Mass Index (BMI), medication count, gender, stenting, systolic blood pressure (sbp), neurosis and rapid eye movement. +3 more findings

• Digital Tools
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

The impacts of air pollution on mortality and hospital readmission among Medicare beneficiaries with Alzheimer's disease and Alzheimer's disease-related dementias: a national retrospective cohort study in the USA

58/100 ✓ Peer-reviewed How common it is The Lancet Planetary Health

Key finding: In both the mortality and readmission cohorts we found significant associations with each pollutant. +4 more findings

• Risk Factors
• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

The Dementia SomaSignal Test (dSST): A plasma proteomic predictor of 20‐year dementia risk

59/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: In addition to outperforming existing plasma biomarkers, the dSST predicted mid-life dementia risk over a 20-year follow-up across two independent cohorts with different ethnic backgrounds (areas under the curve [AUCs]: dSST 0.68-0.70, dSST+age 0.75-0.81). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Risk factors of dementia in a cohort of individuals with mild cognitive impairment in the Italian Interceptor project

46/100 ✓ Peer-reviewed How common it is European Journal of Neurology

Key finding: From 356 participants, 104 were MCI-C, whereas 252 were MCI-NC. +4 more findings

• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

The Nun Study: Insights from 30 years of aging and dementia research

52/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: By examining published literature that reports on or utilizes Nun Study data, we provide an overview of its methodology and key findings, emphasizing its significant contributions to understanding cognitive impairment and related neuropathologies.

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The Incidence and Prevalence of Dementia Among Ontario Adults With and Without Intellectual and Developmental Disabilities

36/100 ✓ Peer-reviewed How common it is International Journal of Geriatric Psychiatry

Key finding: Compared to persons without IDD, cumulative incidence of dementia was on average 4.27 and 5.33 times higher in persons with Non-DS IDD and DS respectively and period prevalence of dementia was on average 4.87 and 5.93 times higher in persons with Non-DS IDD and DS respectively. +1 more finding

• Risk Factors

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Plasma proteomics for cognitive decline and dementia—A Southeast Asian cohort study

54/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: Of 1441 plasma proteins surveyed, a 12-protein signature significantly predicted cognitive decline (q-value < .05). +4 more findings

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The Holy Grail: highlighting the need for equitable access to dementia treatments and clinical trials

40/100 ✓ Peer-reviewed Disparities The Lancet Regional Health - Western Pacific

Key finding: In the last 5 years significant progress has been made in potential dementia treatments, yet many of these treatments come with significant burdens on the healthcare system that may limit access to treatment and care for patients.

• Health Equity
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Characterizing the olfaction and dementia association in the community‐based ARIC study

52/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Compared to good olfaction, moderate olfaction (hazard ratio [HR]: 1.53, 95% confidence interval [CI]: 1.26 to 1.86), hyposmia (HR: 2.24, 95% CI: 1.81 to 2.78), and anosmia (HR: 3.47, 95% CI: 2.77 to 4.34) were all associated with higher dementia hazard; these associations were consistent across age, race, sex, and APOE ε4 groups. +4 more findings

Full summary, score breakdown and related studies → Original source

Physical and mental demands of work associated with dementia risk in later life

52/100 ✓ Peer-reviewed Disparities The Journal of Prevention of Alzheimer s Disease

Key finding: Over a follow-up period of 6.2 years, 513 participants were diagnosed with dementia. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Development and internal validation of a risk prediction model for dementia in a rural older population in China

58/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: During the 4-year follow-up, 134 individuals were diagnosed with dementia. +4 more findings

• Health Equity

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Using a Trauma-Informed Care Approach to Understand Family Caregivers’ Experiences of Accessing Formal Supports in Dementia Care

46/100 ✓ Peer-reviewed Caregiving Journal of Family Nursing

Key finding: Deductive analyses demonstrated that participants' experiences aligned with existing TIC principles.

• Caregiving

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The Number Of Family Caregivers Helping Older US Adults Increased From 18 Million To 24 Million, 2011–22

52/100 ✓ Peer-reviewed Caregiving Health Affairs

Key finding: Drawing on the linked National Health and Aging Trends Study and National Study of Caregiving, we found that the numbers of family caregivers providing help to older adults increased by nearly six million between 2011 and 2022, rising from 18.2 million to 24.1 million. +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

State-dependent functional network connectivity alterations in post-stroke dementia with subcortical lesions

41/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: We identified 13 meaningful resting-state networks, and the dFNC among them derived four states exhibiting different connection patterns. +4 more findings

Full summary, score breakdown and related studies → Original source