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Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer's disease variants
Michael Rullmann, Dylan Henssen, Juliana T Melasch, Cordula Scherlach, Dorothee Saur, Matthias L Schroeter, Solveig Tiepolt, Norman Koglin et al.. European journal of nuclear medicine and molecular imaging, 2025-02-12
Topic: Plasma and spinal-fluid biomarkers
The aAD patients showed significantly higher tau accumulation, relative hypoperfusion and grey matter density loss in the temporal lobes compared to PCA and lvPPA patients. PCA patients, on the other hand, showed significantly higher tau accumulation in the occipital lobe as compared to aAD patients. Relative hypoperfusion in the occipital lobe and loss of functional connectivity of the posterior cingulate cortex to supplementary visual cortical regions helped to distinguish PCA from lvPPA. Tau accumulation in the cerebellum and microstructural changes in the cingulum were found to help differentiate lvPPA from aAD. This study highlights structural and functional differences between patients with different AD phenotypes. Differences in regional tau PET signals suggest that refinements in the Braak staging system are needed for the non-aAD cases. These patterns of tau accumulation align with the cascading network failure hypothesis, though more research is needed to warrant the here presented results in larger patient cohorts.
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APA 7th
Rullmann, M., Henssen, D., Melasch, J. T., Scherlach, C., Saur, D., Schroeter, M. L., et al. (2025). Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer's disease variants. European journal of nuclear medicine and molecular imaging. https://doi.org/10.1007/s00259-025-07135-z
Vancouver
Rullmann M, Henssen D, Melasch JT, Scherlach C, Saur D, Schroeter ML, et al. Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer's disease variants. European journal of nuclear medicine and molecular imaging. 2025. doi:10.1007/s00259-025-07135-z. PMID: 39937274.
BibTeX
@article{rullmann2025-39937274,
author = {Rullmann, Michael and Henssen, Dylan and Melasch, Juliana T and Scherlach, Cordula and Saur, Dorothee and Schroeter, Matthias L and Tiepolt, Solveig and Koglin, Norman and others},
title = {{Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer's disease variants}},
journal = {European journal of nuclear medicine and molecular imaging},
year = {2025},
doi = {10.1007/s00259-025-07135-z},
pmid = {39937274},
url = {https://doi.org/10.1007/s00259-025-07135-z}
}
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Key findings
- The aAD patients showed significantly higher tau accumulation, relative hypoperfusion and grey matter density loss in the temporal lobes compared to PCA and lvPPA patients.
- PCA patients, on the other hand, showed significantly higher tau accumulation in the occipital lobe as compared to aAD patients.
- Relative hypoperfusion in the occipital lobe and loss of functional connectivity of the posterior cingulate cortex to supplementary visual cortical regions helped to distinguish PCA from lvPPA.
- Tau accumulation in the cerebellum and microstructural changes in the cingulum were found to help differentiate lvPPA from aAD.
- This study highlights structural and functional differences between patients with different AD phenotypes.
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Study details
- Participants32
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of nuclear medicine and molecular imaging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 32 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39937274) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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