Newest studies

Resting state electroencephalography alpha activity predicts cognitive scores in rapid eye movement sleep behavior disorder

32/100 ✓ Peer-reviewed Risk factors SLEEP Advances

Key finding: Spectral analysis of the rsEEG data revealed that overall power and transient bursting parameters of alpha activity negatively correlated with Montreal Cognitive Assessment test scores. +3 more findings

• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Spatial Distribution and Clustering Patterns of Cognitive Impairment Among the Older Population — 31 PLADs, China, 2024

37/100 ✓ Peer-reviewed Risk factors China CDC Weekly

Key finding: Cognitive impairment severely restricts daily activities and creates significant social and economic burdens.

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Assessment of Healthcare Workers' Compliance with the MIND Diet

27/100 ✓ Peer-reviewed Health systems and care delivery BOĞAZİÇİ TIP DERGİSİ

Key finding: The components of the MIND diet should be evaluated in relation to the dietary habits and cultural background of the population being studied.

• Lifestyle

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Alzheimer's disease and related dementias among Medicare beneficiaries aged ≥ 65 years in rural America, by Census region and select demographic characteristics: 2020

43/100 ✓ Peer-reviewed Health systems and care delivery The Journal of Rural Health

Key finding: The study population consisted of 54 million Medicare data Fee-for-Service (FFS) and Medicare Advantage enrollees aged ≥ 65; 5.3 million beneficiaries were diagnosed with ADRD, and 16.2% (n = 861,337) of beneficiaries diagnosed with ADRD resided in rural America. +3 more findings

• Health Equity
• Policy

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After Risk-Adjustment Change, Dementia Diagnoses Increased In Medicare Advantage Relative To Traditional Medicare

40/100 ✓ Peer-reviewed Health systems and care delivery Health Affairs

Key finding: Using 2017-20 data for 100 percent of community-dwelling beneficiaries enrolled in Medicare, we evaluated how the reintroduction of dementia to the risk-adjustment model affected rates of new (incident) dementia diagnoses among beneficiaries enrolled in MA relative to those enrolled in traditional Medicare. +4 more findings

• Policy

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Fainting Couch

25/100 ✓ Peer-reviewed Risk factors Fourth Genre Explorations in Nonfiction

Key finding: My feels Victorian because it is There are people feels Victorian because of I am I know I am I still for the and I could have If I make something it will not feel like such a but I might not be able to make anything I to make both for the and the I have something when I am I feel so from my own life that it is like a that I am When it happens when I am I the if the students think I am when I am just being much of teaching is anyway. won't know I am not in the When it happens and I am it feels like I am enough to be by the of When it happens and I am with my it is It is like and for each other when is in the I do not want to be a for them. +4 more findings

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Access to Neighborhood Amenities and Services and the Risk of 2-Year Nursing Home Placement Among Persons Living With Dementia

31/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: +1 more finding

• Care Services

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The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology

35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Handbook of clinical neurology

Key finding: It concludes with a description of the NGF metabolic pathway and its dysregulation in Alzheimer disease (AD) and Down syndrome pathology, explaining the progressive atrophy of BFCNs, which starts at preclinical stages and is reflected in body fluid biomarkers.

• Brain Biology

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Atrial Fibrillation: A Review

57/100 ✓ Peer-reviewed Prevention and risk JAMA

Key finding: AF is associated with significantly increased risk of stroke, heart failure, myocardial infarction, dementia, chronic kidney disease, and mortality. +3 more findings

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Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial

67/100 ✓ Peer-reviewed Treatments JAMA psychiatry

Key finding: Of 486 older adults who provided consent, 375 (with rMDD, MCI, or both) received at least 1 intervention session (mean [SD] age, 72.2 [6.4] years; 232 women [62%] and 143 men [38%]). +2 more findings

• Clinical Trials
• Early Stage

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Amyloid-Related Imaging Abnormalities (ARIA) in Clinical Trials of Gantenerumab in Early Alzheimer Disease

77/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: These results show that in addition to APOE ε4 allele count, severity of Aβ neuropathology and comorbid cerebrovascular pathology may be relevant for clinicians prescribing anti-Aβ monoclonal antibodies for early AD and developing individualized safety monitoring plans. +1 more finding

• Clinical Trials
• Side Effects
• Brain Scans

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Deferiprone in Alzheimer Disease: A Randomized Clinical Trial

78/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: Elevated brain iron observed in AD has been associated with accelerated cognitive decline and may be a tractable drug target. +4 more findings

• Clinical Trials

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Intranasal oxytocin for apathy in people with frontotemporal dementia (FOXY): a multicentre, randomised, double-blind, placebo-controlled, adaptive, crossover, phase 2a/2b superiority trial

69/100 ✓ Peer-reviewed Clinical trials The Lancet Neurology

Key finding: The primary outcome was difference in the change in Neuropsychiatric Inventory apathy scores for oxytocin versus placebo periods in the per-protocol population after 6 weeks of treatment. +1 more finding

• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Multiple-Dose Results from an Ongoing Phase 1 Study of Mivelsiran, an Investigational RNA Interference Therapeutic Targeting Amyloid-Beta Precursor Protein for Alzheimer's Disease

16/100 ⚠ Conference abstract — not peer-reviewed Clinical trials Alzheimer's & Dementia (AAIC 2025 conference abstract)

Key finding: Single ascending dose (100mg, n=9) cut CSF sAPPbeta by 84.5% at 1 month, still down 61.1% at 10 months +4 more findings

• Clinical Trials
• Brain Biology
• Treatments

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Interim biomarker results for trontinemab, a novel Brainshuttle antibody in development for the treatment of Alzheimer's disease

16/100 ⚠ Conference abstract — not peer-reviewed Clinical trials Alzheimer's & Dementia (AAIC 2025 conference abstract)

Key finding: Randomized, double-blind, placebo-controlled Phase Ib/IIa multiple ascending dose design +4 more findings

• Clinical Trials
• Treatments

Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Tablet-based cognitive assessment in a multisite study of early-onset AD: association with pen-and-paper tests and PET measures of amyloid and tau

16/100 ⚠ Conference abstract — not peer-reviewed Getting a diagnosis Alzheimer's & Dementia (AAIC 2025 conference abstract)

Key finding: 475 participants across 16 sites; 83 unimpaired, 146 MCI, 246 mild dementia (per associated TabCAT/LEADS abstract) +4 more findings

• Diagnosis

Scored 36 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Global burden of young-onset dementia, from 1990 to 2021: an age-period-cohort analysis from the global burden of disease study 2021

47/100 ✓ Peer-reviewed How common it is Translational Psychiatry

Key finding: Global young-onset dementia prevalence rose 211% from 3.7 million (1990) to 7.8 million cases (2021) +4 more findings

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Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform

68/100 ✓ Peer-reviewed Biomarkers Nature Medicine

Key finding: 1,767 participants across 5 cohorts, including a primary care cohort (n=548) +4 more findings

• Biomarkers

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Assessment of the efficacy of palliative sedation in advanced cancer patients by evaluating discomfort levels: a prospective, international, multicenter observational study

51/100 ✓ Peer-reviewed End-of-life care BMC medicine

Key finding: In 78 participants, discomfort levels were monitored during palliative sedation. +4 more findings

• End-of-Life Care

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Do Medicare Beneficiaries Under Accountable Care or Medicare Advantage Use Lower Quality Nursing Homes?

37/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Among SNF admissions from 2013 to 2018, the share of ACO-attributed beneficiaries increased from 7.6% to 20.2%, MA enrollees increased from 25.2% to 32.8%, and non-ACO-attributed TM enrollees decreased from 67.2% to 47.3%. +3 more findings

• Care Services
• Policy

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Clinical validity of IntelliSpace Cognition digital assessment platform in mild cognitive impairment

57/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in psychology

Key finding: After ranking the cognitive scores by effect size, we found that the memory score was the most impaired, followed by executive functioning. +1 more finding

• Diagnosis
• Early Stage
• Digital Tools

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Blood-based biomarkers and plasma Aβ assays in the differential diagnosis of Alzheimer's disease and behavioral-variant frontotemporal dementia

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: The novel IP-MS assay measuring the Aβ42/40 ratio demonstrated an AUC of 0.82 for differentiating AD from control subjects. +4 more findings

• Biomarkers
• Diagnosis
• Brain Biology

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Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution

43/100 ✓ Peer-reviewed Genetics Aging

Key finding: Moreover, CpGs from these clocks display a small but significant overlap with the causal DamAge-clock, mapping to key genes implicated in neurodegeneration.

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Longitudinal Pain Management Patterns and Risk of Adverse Outcomes in Older Adults: Insights from Group-Based Multi-Trajectory Modeling

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics Authorea Preprints

Key finding: These findings highlight that extensive long-term utilization of pain management strategies in older adults is associated with increased risks of adverse outcomes, particularly hospitalizations and incident dementia, especially among fit older adults, emphasizing the need for careful monitoring and personalized approaches to pain management in older populations, balancing effective pain control with minimization of potential long-term risks. +4 more findings

Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies

71/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Hallucinations, delusions, and depression were more common in DLB than in AD and, in a subgroup with longitudinal follow-up, persistent hallucinations and NPSs were associated with lower p-tau181 and p-tau231 in DLB. +4 more findings

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source