Newest studies

Iatrogenic cerebral proteinopathies—The dawn of transmissible neurodegeneration? The example of cerebral amyloid angiopathy

39/100 ✓ Peer-reviewed Brain tissue and pathology Frontiers in Neurology

Key finding: Several reports confirmed possible inadvertent iatrogenic intracranial transmission of Aβ pathology via medical and surgical procedures (1,2).A common molecular mechanism, described in prion diseases, is proposed to trigger the replication and spread of different misfolded proteins in the central nervous system (CNS), causing different neurodegenerative diseases associated with disease-specific proteins such as α-synuclein in Parkinson's disease, and amyloid-beta (Aβ) in Alzheimer's disease, and cerebral amyloid angiopathy (CAA) (3). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Artificial Intelligence–Enhanced Multi-Algorithm R Shiny Application for Predictive Modeling and Analytics: Case Study of Alzheimer Disease Diagnostics

40/100 ✓ Peer-reviewed Brain scans and imaging JMIR Aging

Key finding: The Neural Network classifier achieved an accuracy of 91% with a 95% CI ranging from 0.79-0.97 and an AUC of 94%, on the test set after identifying the most significant features for AD prediction. +4 more findings

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study

65/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: Sample 1 included 1656 participants (mean [range] age, 58.1 [29.7-85.6] years; 903 female [54.5%]), and sample 2 included 935 participants (mean [range] age, 67.6 [60.0-85.6] years; 518 female [55.4%]). +3 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Blood-based biomarkers for detecting Alzheimer's disease pathology in cognitively impaired individuals within specialized care settings: A systematic review and meta-analysis

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: Studies evaluating the diagnostic test accuracy of plasma phosphorylated tau (p-tau) and amyloid beta (Aβ) tests (p-tau217, %p-tau217, p-tau181, p-tau231, and Aβ42/Aβ40) compared to reference standard tests (cerebrospinal fluid [CSF] AD biomarkers, amyloid positron emission tomography [PET], or neuropathology) in individuals with cognitive impairment (mild cognitive impairment or dementia) in specialized care settings were included. +3 more findings

• Biomarkers
• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Lymphoid gene expression supports neuroprotective microglia function

45/100 ✓ Peer-reviewed Laboratory science Nature

Key finding: Identified a microglial subpopulation enriched for lymphoid-associated genes that is neuroprotective against amyloid pathology +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Long-term cost-effectiveness of a more accurate diagnostic work-up for dementia

59/100 ✓ Peer-reviewed Costs and economics Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: PET participants lived longer in community (0.26 years, 95% confidence interval [CI]: 0.05 to 0.45) and overall (0.15, CI: 0.02 to 0.27), but did not have statistically different health insurance (€703, CI: -3974 to 5045) or total costs including institutionalization (-€8258, CI: -20,622 to 3377). +4 more findings

• Policy

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Amygdalar and hippocampal volume loss in limbic-predominant age-related TDP-43 encephalopathy

46/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

Key finding: LATE-NC is most commonly found in the amygdala and hippocampus and is associated with progressive amnestic decline in individuals with a neurodegenerative disease. +3 more findings

• Brain Biology
• Brain Scans

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Comparative safety of cholinesterase inhibitors and memantine for dementia: a protocol for a network meta-analysis of randomized controlled trials

71/100 ✓ Peer-reviewed Treatments Systematic reviews

Key finding: By addressing gaps in prior NMAs, this study aims to provide an in-depth evaluation of safety outcomes associated with different ChEI and memantine doses and formulations across various dementia types. +2 more findings

• Treatments
• Side Effects

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Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

46/100 ✓ Peer-reviewed Inflammation and the immune system Nature Metabolism

Key finding: Our findings establish CIII ROS as an important immunometabolic signal transducer and tractable therapeutic target in neurodegenerative disease.

• Brain Biology

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MMSE in primary care practice: why good tests can mislead in the wrong context

33/100 ✓ Peer-reviewed Cognitive tests and assessment European Journal of Ageing

Key finding: Similar results were obtained applying a cutoff score of 21. +3 more findings

• Diagnosis
• Care Services

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Association of zinc deficiency and risk of new-onset dementia: a retrospective cohort study

59/100 ✓ Peer-reviewed How common it is Frontiers in Nutrition

Key finding: Zinc deficiency represents an independent, modifiable risk factor for new-onset dementia with a clear dose-response relationship. +4 more findings

• Risk Factors

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Incidence and Risk of Stroke following Dementia: A Nationwide Cohort Study in South Korea

49/100 ✓ Peer-reviewed How common it is Dementia and Geriatric Cognitive Disorders

Key finding: During a mean follow-up of 2.49 years (median, 1.99; standard deviation, 2.07; interquartile range, 2.66), dementia was significantly associated with increased stroke risk (aHR, 3.19; 95% confidence interval, 2.84-3.57). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Prevalence of living alone with dementia and other progressive neurological conditions: findings from primary care data in England

49/100 ✓ Peer-reviewed Disparities BMC Medicine

Key finding: In 2023, there were 205,507 people with dementia in the CPRD database, 40,244 with Parkinson's disease, 3515 with MND and 1672 with Huntington's disease. +4 more findings

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Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study

46/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: < 0.035), consistent with a neurodegenerative pattern. +2 more findings

• Brain Scans

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Missing data and imputation in the international studies following the Harmonized Cognitive Assessment Protocol

38/100 ✓ Peer-reviewed Getting a diagnosis The Journals of Gerontology Series B

Key finding: Various missing codes were used to document reasons for missingness. +4 more findings

• Diagnosis

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Towards pharmacological prevention of Alzheimer disease

43/100 ✓ Peer-reviewed Drug development Nature reviews. Neurology

Key finding: Consequently, primary and secondary prevention of AD have become feasible goals. +4 more findings

• Treatments
• Brain Biology
• Prevention

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Genetic Downregulation of Interleukin‐6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis

41/100 ✓ Peer-reviewed Vascular contributions Journal of the American Heart Association

Key finding: variants) was not associated with small vessel stroke (odds ratio [OR], 1.02 [95% CI, 0.95-1.10]), magnetic resonance imaging-confirmed lacunar stroke (OR, 0.95, [95% CI, 0.81-1.11]), nonlobar intracerebral hemorrhage (OR, 1.04 [95% CI, 0.72-1.50]), or vascular dementia (OR, 1.09 [95% CI, 0.95-1.25]). +4 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Feasibility, acceptability, and preliminary efficacy protocol of an intervention for caregivers of hospice patients living with dementia: A pilot randomized control trial

45/100 ✓ Peer-reviewed End-of-life care PLoS ONE

Key finding: We have enrolled 29 clinicians and 53 FCPs and aim to have 24 clinicians matched with 96 FCPs (N = 120) to complete the intervention. +2 more findings

• End-of-Life Care
• Clinical Trials

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Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusion

35/100 ✓ Peer-reviewed Disease mechanisms Journal of Cerebral Blood Flow & Metabolism

Key finding: In this study, we sought to determine whether enhanced myelination could prevent cognitive impairment associated with CCH. +2 more findings

• Brain Biology

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Heart rate response and recovery during exercise and dementia risk: a prospective UK biobank study

44/100 ✓ Peer-reviewed Long-term cohort studies Scientific Reports

Key finding: We found that 519 participants were ascertained with dementia, including 232 with Alzheimer's disease (AD) and 85 with vascular dementia (VaD) during a median follow-up period of 12.62 years. +3 more findings

• Risk Factors
• Lifestyle

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Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

55/100 ✓ Peer-reviewed Digital health tools npj Dementia

Key finding: Explainability analyses revealed reduced linguistic informativeness as a key AD indicator.

• Digital Tools
• Diagnosis

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Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies

47/100 ✓ Peer-reviewed Digital health tools Molecular Neurodegeneration

Key finding: Emerging evidence suggests α-synuclein oligomers may be more toxic than Lewy-related pathology. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Supporting Dementia Caregiving With a Mobile Care Ecosystem: Development and Mixed Methods Study

38/100 ✓ Peer-reviewed Caregiving JMIR Aging

Key finding: In phase 1, the mean system usability scores increased from 65.4 (SD 11.8) in round 1 to 73.8 (SD 15.9) in round 3, exceeding the benchmark of 68. +4 more findings

• Clinical Trials
• Caregiving

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A multivariate approach to identify association between peripheral blood DNA methylation and cerebrospinal fluid biomarkers of Alzheimer disease

43/100 ✓ Peer-reviewed Tau biomarkers Scientific reports

Key finding: Although many studies have correlated DNA methylation in blood samples with risk of clinical AD diagnosis, few have examined links with AD neuropathology. +3 more findings

• Biomarkers

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Digital Detection of Dementia in Primary Care: A Randomized Clinical Trial

70/100 ✓ Peer-reviewed Getting a diagnosis JAMA Network Open

Key finding: Compared with the usual care clinics (12-month incidence, 213 of 1724 [12.4%]), the odds of an incident ADRD diagnosis were higher in the clinics randomized to QDRS plus PDM (12-month incidence, 355 of 2301 [15.4%]; adjusted odds ratio [AOR], 1.31; 95% CI, 1.05-1.64) but not the clinics randomized to PDM only (12-month incidence, 134 of 1300 [10.3%]; AOR, 0.84; 95% CI, 0.63-1.11]). +2 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source