Newest studies

Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study

61/100 ✓ Peer-reviewed Long-term cohort studies Brain, behavior, and immunity

Key finding: Recent studies have associated immune abnormalities with dementia. +3 more findings

• Risk Factors

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Gantenerumab for early Alzheimer's disease: a systematic review and meta-analysis

84/100 ✓ Peer-reviewed Treatments Expert review of neurotherapeutics

Key finding: In this meta-analysis, consistent results suggest that gantenerumab is not safe and efficient for early AD, showing no improvement in clinical scores for AD and being associated with the occurrence of ARIA-E and ARIA-H. +2 more findings

• Side Effects

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Mental Health Treatment Among Nursing Home Residents With Alzheimer's Disease and Related Dementias

75/100 ✓ Peer-reviewed Disparities Journal of the American Medical Directors Association

Key finding: receipt of (1) any mental health treatment (medication or psychotherapy); (2) any psychotherapy in a calendar quarter. +4 more findings

• Health Equity
• Treatments

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Electroacupuncture improves vascular cognitive impairment no dementia: A Randomized Clinical Trial

79/100 ✓ Peer-reviewed Brain scans and imaging Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Key finding: EA intervention could increase the MoCA score and improve the neutral and consistency response of the STROOP test in VCIND patients (P < 0.05). fMRI functional connectivity analysis showed that, after EA, the default mode network (DMN) function of the posterior cingulate gyrus, left middle frontal gyrus, left anterior cingulate gyrus, left and right superior temporal gyrus, right insula, left precentral gyrus and other brain regions were significantly higher than that in the control group. +4 more findings

• Clinical Trials

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Benchmarking of a multi-biomarker low-volume panel for Alzheimer's Disease and related dementia research

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Overall, we have found that CSF measures of Aß42/40, NfL, GFAP, and p-tau217 are highly correlated and have similar predictive performance when measured by immunoassay, mass-spectrometry or NULISA. +1 more finding

• Biomarkers

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Alzheimer's Disease Linkage to Real-World Evidence (AD-LINE) Study: Linking Claims Data to Phase 3 GRADUATE Study of Gantenerumab

46/100 ✓ Peer-reviewed Health systems and care delivery The Journal of Prevention of Alzheimer s Disease

Key finding: In total, 147 participants across 21 US sites were invited to participate and 111 provided informed consent. +4 more findings

• Clinical Trials

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A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial

79/100 ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy

Key finding: Within 17 months, participant recruitment has been successfully completed (N = 1210; mean age: 67.7 years (SD: 4.6); 64% female). +1 more finding

• Clinical Trials
• Lifestyle

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CSF and plasma biomarkers in cerebral amyloid angiopathy: A single-center study and a systematic review/meta-analysis

60/100 ✓ Peer-reviewed Tau biomarkers European stroke journal

Key finding: There are limited data regarding cerebrospinal fluid (CSF) and plasma biomarkers among patients with Cerebral Amyloid Angiopathy (CAA). +3 more findings

• Biomarkers

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Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion

43/100 ✓ Peer-reviewed Disease mechanisms Science advances

Key finding: Our results shed light on the mechanism underlying autophagy evasion by protein aggregates and their consequent accumulation in disease.

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Dementia and metabolic syndrome: a bibliometric analysis

52/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: A total of 717 articles were identified, showing an upward trend in annual publications. +4 more findings

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Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men

80/100 ✓ Peer-reviewed Drug development Metabolism: clinical and experimental

Key finding: Several bacterial species belonging to the Proteobacteria (Escherichia coli) and Verrucomicrobia (Akkermansia muciniphila) phyla were positively associated with metformin treatment, while bacterial species belonging to the Firmicutes phylum (Romboutsia timonensis, Romboutsia ilealis) were negatively associated. +4 more findings

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APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

46/100 ✓ Peer-reviewed Genetics Cellular & molecular biology letters

Key finding: The pathway analysis of six major cell types revealed a strong association between APOE2 and cellular stress and energy metabolism, particularly in excitatory and inhibitory neurons, which was found to be more pronounced in the presence of beta-amyloid (Aβ). +4 more findings

• Brain Biology

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Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice

41/100 ✓ Peer-reviewed TREM2 and immune genetics Science translational medicine

Key finding: As a result, normally innocuous visceral or somatic stimuli elicit uncontrolled activation of spinal sympathetic reflexes that contribute to systemic disease and organ-specific pathology. +1 more finding

• Brain Biology

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Remote and unsupervised digital memory assessments can reliably detect cognitive impairment in Alzheimer's disease

54/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Our results demonstrate that unsupervised digital memory assessments might be used for diagnosis and prognosis in Alzheimer's disease, potentially in combination with plasma biomarkers. +3 more findings

• Digital Tools
• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Acceptable performance of blood biomarker tests of amyloid pathology - recommendations from the Global CEO Initiative on Alzheimer's Disease

62/100 ✓ Peer-reviewed Biomarkers Nature Reviews Neurology

Key finding: Amyloid PET status was identified as the reference standard. +4 more findings

• Biomarkers

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Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions

45/100 ✓ Peer-reviewed Prevention trials Metabolites

Key finding: As a result, dietary polyphenols from natural plant-based antioxidants and adherence to the Mediterranean diet, along with physical exercise, are promising complementary therapies to delay or prevent the onset of metabolic syndrome and counteract diabesity and cardiovascular diseases, as well as to protect against neurodegenerative disorders and cognitive decline. +1 more finding

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

The risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis

50/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The cognitive impairment patterns and the association with Alzheimer's disease (AD) in mental disorders remain poorly understood. +3 more findings

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Reduced GLP-1R availability in the caudate nucleus with Alzheimer's disease

43/100 ✓ Peer-reviewed Drug development Frontiers in aging neuroscience

Key finding: Mounting evidence indicates that the potential of GLP-1R agonists, mimicking a 30 amino acid ligand, GLP-1, extends to the treatment of neurodegenerative conditions, with a particular focus on Alzheimer's disease (AD). +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer's disease

50/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica

Key finding: However, the side effects observed in clinical trials of BACE1 inhibitors, including reduction in brain volume and cognitive worsening, suggest that the exact role of BACE1 in AD pathology is not fully understood. +3 more findings

• Biomarkers
• Brain Scans

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Association of the Area Deprivation Index With Dementia Basic Workup and Diagnosis in Central and Western Virginia

40/100 ✓ Peer-reviewed Risk factors Neurology Clinical Practice

Key finding: The study included 13,431 individuals diagnosed with dementia at UVA (n = 7,152) and Carillion Clinic (n = 6,279). +4 more findings

• Diagnosis

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Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults

80/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: All autonomic networks were positively associated with Aβ42/40 ratio and remained so after adjustment for age, sex, and APOE4 carrier status. +4 more findings

• Biomarkers

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Tau, Glial Fibrillary Acidic Protein, and Neurofilament Light Chain as Brain Protein Biomarkers in Cerebrospinal Fluid and Blood for Diagnosis of Neurobiological Diseases

43/100 ✓ Peer-reviewed Biomarkers International journal of molecular sciences

Key finding: This combined detection system of brain protein biomarkers holds significant promise for developing more specific and accurate clinical tools that can identify the type and stage of human neurological diseases with greater precision.

• Biomarkers
• Diagnosis

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Home Health Quality among Hospitalized Older Adults with Alzheimer's Disease and Related Dementia: Association with Race/Ethnicity and Dual Eligibility before and during the COVID Pandemic

53/100 ✓ Peer-reviewed Risk factors Journal of the American Medical Directors Association

Key finding: Before the pandemic, Black and Hispanic individuals had significantly higher probabilities of discharge to below-average quality HHAs compared with white individuals (3.4 and 3.9 percentage points, respectively).

• Care Services
• Health Equity

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TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice

47/100 ✓ Peer-reviewed TREM2 and immune genetics Cell death & disease

Key finding: Its role in renal injury, in particular, unilateral ureteral obstruction (UUO) or ischemia-reperfusion injury (IRI)-induced renal injury remains unclear. +3 more findings

• Genetics
• Brain Biology

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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial

74/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy

Key finding: Fifty-one AD patients enrolled, mean age 73.5. +3 more findings

• Clinical Trials
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source