Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,476–11,500 of 27,380 studies, newest first · page 460 of 1096.
July 2020 14
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2020-07-01
Association Between Cardiovascular Disease and Long-term Exposure to Air Pollution With the Risk of Dementia
74/100 ✓ Peer-reviewed Vascular contributions JAMA neurology
Key finding: This study found that long-term exposure to air pollution was associated with a higher risk of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-01
Economic Burden of Postoperative Neurocognitive Disorders Among US Medicare Patients
69/100 ✓ Peer-reviewed Clinical safety JAMA network open
Key finding: The findings of this cohort study suggest that among older Medicare patients undergoing surgical treatment, a diagnosis of a PND was associated with an increase in health care costs for up to 1 year following the surgical procedure. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-01
The role of diet in preventing and reducing cognitive decline
38/100 ✓ Peer-reviewed Prevention trials Current opinion in psychiatry
Key finding: This review summarises the most recent evidence regarding the effects of diet in preventing and reducing age-related cognitive decline and neurodegenerative diseases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-01
Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer's Disease
53/100 ✓ Peer-reviewed Inflammation and the immune system CNS drugs
Key finding: Infection results in neuroinflammation, leading to, and sustained by, systemic inflammation, causing eventual neurodegeneration, and the senescence of the immune cells.
Full summary, score breakdown and related studies → Original source
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2020-07-01
Alzheimer's Disease and Related Disorders Prevalence Differs by Appalachian Residence in Ohio
35/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Negative binomial regression was used to estimate prevalence overall, by Appalachian Regional Commission's Appalachian/non-Appalachian designation, and by rural/urban (Rural-Urban Continuum Codes) classification. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-01
Increased Prevalence in Alzheimer Disease in the Northeast Tennessee Region of the United States
32/100 ✓ Peer-reviewed Risk factors Southern Medical Journal
Key finding: The PORs of AD in rural counties in NTR increased by 18.3%, 4.7%, and 19% compared with urban counties for 2013, 2014, and 2015, respectively. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-01
Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning
50/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders
Key finding: Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-01
Subjective cognitive decline as a predictor of future cognitive decline: a systematic review
57/100 ✓ Peer-reviewed Mild cognitive impairment Dementia & neuropsychologia
Key finding: Recent studies suggest that SCD could be a risk factor for objective cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-01
Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium
82/100 ✓ Peer-reviewed How common it is Neurology
Key finding: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-01
Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals
67/100 ✓ Peer-reviewed Disparities JAMA neurology
Key finding: Among 34 349 participants, 19 378 individuals who were free of stroke and dementia and had longitudinal BP, cognitive, and covariate data were included in the analysis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-01
Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes
69/100 ✓ Peer-reviewed Getting a diagnosis JAMA neurology
Key finding: This study's findings suggest that PET imaging with [18F]flortaucipir could be used to identify the density and distribution of AD-type tau pathology and the presence of high levels of AD neuropathological change, supporting a neuropathological diagnosis of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-01
Dietary interventions and cognition of Alzheimer's disease patients: a systematic review of randomized controlled trial
49/100 ✓ Peer-reviewed Treatments Dementia & neuropsychologia
Key finding: It is estimated that by 2030 there will be 82 million people in the world with dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-01
Effect of Rotigotine vs Placebo on Cognitive Functions Among Patients With Mild to Moderate Alzheimer Disease: A Randomized Clinical Trial
65/100 ✓ Peer-reviewed Treatments JAMA network open
Key finding: In this randomized clinical trial, rotigotine treatment did not significantly affect global cognition in patients with mild to moderate AD; however, improvement was observed in cognitive functions highly associated with the frontal lobe and in activities of daily living. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-01
Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4
60/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: The genotype KL-VSHET+ is associated with reduced AD risk and Aβ burden in individuals who are aged 60 to 80 years, cognitively normal, and carrying APOE4. +4 more findings
Full summary, score breakdown and related studies → Original source
June 2020 11
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2020-06-30
TRIM32 Deficiency Impairs Synaptic Plasticity by Excitatory-Inhibitory Imbalance via Notch Pathway
39/100 ✓ Peer-reviewed Disease mechanisms Cerebral cortex (New York, N.Y. : 1991)
Key finding: Our electrophysiological studies using hippocampal slices revealed that long-term potentiation of CA1 synapses was impaired in TRIM32 deficient (KO) mice.
Full summary, score breakdown and related studies → Original source
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2020-06-30
Androgens' effects on cerebrovascular function in health and disease
39/100 ✓ Peer-reviewed Vascular contributions Biology of sex differences
Key finding: Men are at a greater risk for stroke and vascular contributions to cognitive impairment and dementia (VCID) compared to women throughout much of the lifespan.
Full summary, score breakdown and related studies → Original source
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2020-06-30
GABAergic Inhibitory Interneuron Deficits in Alzheimer's Disease: Implications for Treatment
41/100 ✓ Peer-reviewed Digital health tools Frontiers in neuroscience
Key finding: Furthermore, there is now evidence suggesting that neural network activity is aberrantly increased in AD patients and animal models due to functional deficits in and decreased activity of GABA inhibitory interneurons, contributing to cognitive deficits.
Full summary, score breakdown and related studies → Original source
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2020-06-30
Family Caregiving at the End of Life and Hospice Use: A National Study of Medicare Beneficiaries
64/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Older adults at the end of life receive a high number of hours of help at the end of life, many from more than one caregiver, which may shape hospice access. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-06-30
Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease
41/100 ✓ Peer-reviewed Disease mechanisms Frontiers in neuroscience
Key finding: Plaques and tangles are associated with sleep-wake cycle disruptions, including the disruptions in non-rapid eye movement (NREM) slow wave sleep (SWS). +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-06-30
Cross-sectional and Longitudinal Assessment of Brain Iron Level in Alzheimer Disease Using 3-T MRI
60/100 ✓ Peer-reviewed Brain scans and imaging Radiology
Key finding: Iron concentration in the deep gray matter and neocortical regions was higher in patients with Alzheimer disease than in healthy control participants. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-06-29
Leaky memories: Impact of APOE4 on blood-brain barrier and dementia
39/100 ✓ Peer-reviewed Vascular contributions Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Key finding: A new study suggests that the leading genetic risk factor for Alzheimer's disease, apolipoprotein E4 (APOE4), is linked to blood-brain barrier breakdown and subsequent cognitive decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-06-29
Gut Microbiota: Implications in Alzheimer's Disease
39/100 ✓ Peer-reviewed Disease mechanisms Journal of clinical medicine
Key finding: In recent years, mounting evidence has shown that there is a bidirectional interaction between the gut and brain, known as the brain-gut axis, and that the intestinal microbiota are closely related to the occurrence and development of neurodegenerative diseases.
Full summary, score breakdown and related studies → Original source
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2020-06-29
Defining a Centiloid scale threshold predicting long-term progression to dementia in patients attending the memory clinic: an [18F] flutemetamol amyloid PET study
48/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging
Key finding: In the 98 participants with long follow-up, Centiloid = 26 provided the highest overall predictive value = 87% (NPV = 85%, PPV = 88%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-06-29
Cellular senescence and Alzheimer disease: the egg and the chicken scenario
50/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neuroscience
Key finding: As ageing is the main risk factor for dementia-related neurodegeneration, changes in the timing or nature of the cellular hallmarks of normal ageing might be key to understanding the events that convert normal ageing into neurodegeneration. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-06-29
The substrate repertoire of γ-secretase/presenilin
48/100 ✓ Peer-reviewed TREM2 and immune genetics Seminars in cell & developmental biology
Key finding: However, in the 21 years since its discovery many more substrates and substrate candidates of γ-secretase were identified. +3 more findings
Full summary, score breakdown and related studies → Original source
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