Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,726–17,750 of 27,380 studies, newest first · page 710 of 1096.
July 2014 25
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2014-07-19
Genome-wide pathway analysis of a genome-wide association study on Alzheimer's disease
79/100 ✓ Peer-reviewed Genetics Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Key finding: ICSNPathway analysis identified 3 candidate SNPs and 2 pathways, which provided 3 hypothetical biological mechanisms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-18
Hierarchical feature representation and multimodal fusion with deep learning for AD/MCI diagnosis
40/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage
Key finding: For the last decade, it has been shown that neuroimaging can be a potential tool for the diagnosis of Alzheimer's Disease (AD) and its prodromal stage, Mild Cognitive Impairment (MCI), and also fusion of different modalities can further provide the complementary information to enhance diagnostic accuracy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-18
Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry
Key finding: Recent in vitro studies have demonstrated that extracellular Aβ can bind to exosomes, which are cell-secreted nanovesicles with lipid membranes that are known to transport their cargos intercellularly. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-18
Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
47/100 ✓ Peer-reviewed How common it is Biological psychiatry
Key finding: These data reinforce the link between gut dysbiosis and neurologic dysfunction and suggest that dietary and/or pharmacologic manipulation of gut microbiota could attenuate the neurologic complications of obesity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-18
Validation of a polygenic risk score for dementia in black and white individuals
70/100 ✓ Peer-reviewed Disparities Brain and behavior
Key finding: Non-Hispanic white and NHB Health and Retirement Study (HRS) participants provided genetic information and either a composite memory score (n = 10,401) or a dementia probability score (n = 7690).
Full summary, score breakdown and related studies → Original source
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2014-07-17
American Geriatrics Society feeding tubes in advanced dementia position statement
36/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Moreover, tube feeding is associated with agitation, greater use of physical and chemical restraints, healthcare use due to tube-related complications, and development of new pressure ulcers.
Full summary, score breakdown and related studies → Original source
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2014-07-17
Insulin resistance predicts brain amyloid deposition in late middle-aged adults
55/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This is the first human study to demonstrate that insulin resistance may contribute to amyloid deposition in brain regions affected by AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-07-16
Motoric cognitive risk syndrome: multicountry prevalence and dementia risk
74/100 ✓ Peer-reviewed How common it is Neurology
Key finding: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-15
Free radicals: properties, sources, targets, and their implication in various diseases
36/100 ✓ Peer-reviewed Risk factors Indian journal of clinical biochemistry : IJCB
Key finding: Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-15
Comorbidity in dementia: update of an ongoing autopsy study
62/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Significant comorbidities were discovered at autopsy in individuals with dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-07-15
Physiological and pathological phosphorylation of tau by Cdk5
40/100 ✓ Peer-reviewed Disease mechanisms Frontiers in molecular neuroscience
Key finding: Several reports have indicated that tau is hyperphosphorylated by Cdk5-p25.
Full summary, score breakdown and related studies → Original source
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2014-07-15
Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies
50/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging
Key finding: EEG recordings were obtained at admission and at the end of the study. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-14
Association of hearing impairment and mortality in older adults
50/100 ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: HI in older adults is associated with increased mortality, independent of demographics and cardiovascular risk factors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-14
Specific Resting-State Brain Networks in Mesial Temporal Lobe Epilepsy
38/100 ✓ Peer-reviewed Risk factors Frontiers in Neurology
Key finding: Two reliable networks, corresponding to statistically significant clusters robustly detected with clustering were labeled as specific to MTLE and one as specific to the control group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-13
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
63/100 ✓ Peer-reviewed Prevention and risk The Lancet Neurology
Researchers analyzed population-based data and relative risks from existing meta-analyses to estimate the population-attributable risk of Alzheimer's disease worldwide, in the USA, Europe, and the UK for seven potentially modifiable risk factors.
Full summary, score breakdown and related studies → Original source
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2014-07-11
Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors
54/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Multiple CMBs or mixed CMBs independently showed higher risk of all-cause dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-10
Effects of several quinones on insulin aggregation
40/100 ✓ Peer-reviewed Treatments Scientific reports
Key finding: Protein misfolding and aggregation are associated with more than twenty diseases, such as neurodegenerative diseases and metabolic diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-10
Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD
53/100 ✓ Peer-reviewed Disease mechanisms Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Key finding: Aβ toxicity is related to oxidative stress, which results in synaptic loss in specific brain areas, eventually leading to cognitive decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-07-09
Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old
47/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology
Key finding: All measures distinguished the dementia and control groups and all markers associated with the cognitive test scores. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-09
Alternate Level of Care Patients in Hospitals: What Does Dementia Have To Do With This?
38/100 ✓ Peer-reviewed Health systems and care delivery Canadian Geriatrics Journal
Key finding: Thirty-three per cent of the hospital beds were occupied with ALC patients; 63% had a diagnosis of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-09
A data-driven model of biomarker changes in sporadic Alzheimer's disease
55/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: By fitting Cox proportional hazards models, we find that baseline model stage is a significant risk factor for conversion from both mild cognitive impairment to Alzheimer's disease (P = 2.06 × 10(-7)) and cognitively normal to mild cognitive impairment (P = 0.033). +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-07-09
Natural history of falls in a population-based cohort of patients with Parkinson's disease: an 8-year prospective study
45/100 ✓ Peer-reviewed Digital health tools Parkinsonism & related disorders
Key finding: Nearly ¾ of the PD cohort reported falling after 8 years of follow-up.
Full summary, score breakdown and related studies → Original source
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2014-07-08
Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia
63/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Carriers (n = 39) and noncarriers (n = 36) had similar neuropsychological performance, except for lower Letter Digit Substitution Test scores in carriers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-08
Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease - How Anti-Diabetics Could be a Solution for Dementia
40/100 ✓ Peer-reviewed Drug development Frontiers in endocrinology
Key finding: T2D principal hallmark is insulin resistance which also occurs in AD, rendering both pathologies more than mere unrelated diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-07-08
Pain and decreased cognitive function negatively impact physical functioning in older adults with knee osteoarthritis
36/100 ✓ Peer-reviewed Cognitive tests and assessment Pain medicine (Malden, Mass.)
Key finding: Worse pain scores and executive function scores were associated with worse physical function in older adults with painful knee OA. +4 more findings
Full summary, score breakdown and related studies → Original source
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