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Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study
Yohanes Tandoro, Hui‐Fang Chiu, Chei-Ling Tan, Ming‐Hong Hsieh, Yi‐Wen Huang, Jianhua Yu, Li‐Shu Wang, Chi‐Ho Chan et al.. npj Science of Food, 2025-02-12
Topic: Brain proteins, microglia and lab models
Alzheimer's disease (AD) is the most common form of dementia. H. pylori infection and overweight have been implicated in AD via the gut-brain axis (GBA). This study aimed to determine whether supplementation of BRBs has a meaningful effect on H. pylori infection, overweight, and AD development in a clinical trial setting. We conducted a randomized placebo-controlled clinical trial in patients with mild clinical dementia who also had H. pylori infection and were overweight. The study was conducted over 10 weeks, consisting of an 8-week intervention period (25 g powder of black raspberries, BRBs, or placebo twice daily, morning and evening) and a 2-week follow-up. The primary outcomes were changes in Clinical Dementia Rating (CDR), Urea Breath Test (UBT), and Body Mass Index (BMI). Consumption of BRBs improved cognitive functions (p 0.05). Besides, BRBs ingestion decreased H. pylori infection and BMI (p < 0.00001 and p < 0.05 respectively) while the placebo group stayed statistically the same (p = 0.98 and p = 0.25 respectively). BRBs significantly decreased inflammatory markers, improved oxidative index, and adiponectin (p < 0.05) compared to the placebo group, while adenosine monophosphate-activated protein kinase (AMPK) and leptin did not significantly change. BRBs modulated the abundance of several fecal probiotics, particularly, Akkermansia muciniphila. Our results provided that BRBs suppressed H. pylori infection, decreased BMI, and rebalanced the gut microbiome, which could improve cognitive functions in mild dementia patients. Longer and larger randomized clinical trials of BRB interventions targeting H. pylori infection, overweight, or mild dementia are warranted to confirm the results from this pilot trial. Trial Registration: ClinicalTrials.gov identifier: NCT05680532.
Key findings
- BRBs significantly decreased inflammatory markers, improved oxidative index, and adiponectin (p < 0.05) compared to the placebo group, while adenosine monophosphate-activated protein kinase (AMPK) and leptin did not significantly change.
- Our results provided that BRBs suppressed H. pylori infection, decreased BMI, and rebalanced the gut microbiome, which could improve cognitive functions in mild dementia patients.
- Longer and larger randomized clinical trials of BRB interventions targeting H. pylori infection, overweight, or mild dementia are warranted to confirm the results from this pilot trial.
Why it matters
In a small 10-week pilot trial, black raspberry supplementation improved cognitive function and reduced H. pylori infection, BMI, and some inflammatory markers in overweight patients with mild dementia and H. pylori infection. The authors state that longer and larger randomized trials are needed, so this does not yet establish a treatment or prevention.
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Study details
- Evidence strengthHigh
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (npj Science of Food) |
| Journal's citation record | 0 / 4 | Npj Science of Food: journal h-index 58 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Chin‐Kun Wang: h-index 20 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | City Of Hope National Medical Center: institution h-index 752 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39939643) |
| Free to read | 2 / 2 | Free to read |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s41538-024-00356-w
- PubMed: 39939643
- Original source →
- Free full text: npj Science of Food →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Tandoro, Y., Chiu, H., Tan, C.-L., Hsieh, M., Huang, Y., Yu, J., et al. (2025). Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study. npj Science of Food. https://doi.org/10.1038/s41538-024-00356-w
Vancouver
Tandoro Y, Chiu H, Tan C.-L, Hsieh M, Huang Y, Yu J, et al. Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study. npj Science of Food. 2025. doi:10.1038/s41538-024-00356-w. PMID: 39939643.
BibTeX
@article{tandoro2025-39939643,
author = {Tandoro, Yohanes and Chiu, Hui‐Fang and Tan, Chei-Ling and Hsieh, Ming‐Hong and Huang, Yi‐Wen and Yu, Jianhua and Wang, Li‐Shu and Chan, Chi‐Ho and others},
title = {{Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study}},
journal = {npj Science of Food},
year = {2025},
doi = {10.1038/s41538-024-00356-w},
pmid = {39939643},
url = {https://doi.org/10.1038/s41538-024-00356-w}
}
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