Newest studies

Clinical implication of anemia in older patients with dementia with lewy bodies

47/100 ✓ Peer-reviewed Disparities Aging Clinical and Experimental Research

Key finding: Participants in the study had an average age of 85.4 ± 7.1 years. +4 more findings

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

An integrated Artificial Intelligence and optimization model for operational efficiency and risk reduction in Letter of Credit examination process

39/100 ✓ Peer-reviewed Prevention and risk Decision Analytics Journal

Key finding: Digital transformation in banking has significantly improved efficiency, including in the critical Letter of Credit (LC) examination area. +1 more finding

• Prevention
• Digital Tools

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Aerobic exercise improves clearance of amyloid-β via the glymphatic system in a mouse model of Alzheimer's Disease

43/100 ✓ Peer-reviewed Prevention trials Brain research bulletin

Key finding: The funding showed that APP/PS1 mice have learning and memory impairment, and the glymphatic system is dysfunction. +3 more findings

• Brain Biology

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Biofluid biomarker changes following treatment with sabirnetug (ACU193) in INTERCEPT-AD, a phase 1 trial in early Alzheimer's disease

39/100 ✓ Peer-reviewed Disease mechanisms The Journal of Prevention of Alzheimer s Disease

Key finding: and neurogranin changes correlated with sabirnetug-AβO target engagement (p ≤ 0.01). +4 more findings

• Clinical Trials
• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Factors influencing time to support in young-onset dementia: survival analysis of data from the Swedish Dementia Registry (SveDem)

54/100 ✓ Peer-reviewed Cognitive tests and assessment Aging & Mental Health

Key finding: Living with another adult and higher MMSE scores were significantly associated with later access to home help services (p < 0.001) and care facilities (p < 0.001). +2 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

CONVERTING MOCA-J TO MMSE-J IN COMMUNITY-DWELLING JAPANESE OLDER ADULTS: A PILOT STUDY

39/100 ✓ Peer-reviewed Cognitive tests and assessment PSYCHOLOGIA

Key finding: In addition, our conversion table demonstrated the advantage of using the MoCA-J for early detection of cognitive decline.

• Diagnosis

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Dementia prevalence within the Kingdom of Saudi Arabia National Guard Health System (2015–2023): An exploratory epidemiological study

41/100 ✓ Peer-reviewed How common it is Journal of Alzheimer s Disease

Key finding: Significant differences between genders were observed, particularly in the age at diagnosis (p = 0.003) and the prevalence of ischemic strokes as a risk factor (p < 0.001).ConclusionsIn this multicenter study utilizing the NGHS cohort, Alzheimer's disease emerged as the most prevalent subtype of dementia.

• Care Services

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Global burden of young-onset dementia, from 1990 to 2021: an age-period-cohort analysis from the global burden of disease study 2021

52/100 ✓ Peer-reviewed How common it is Translational Psychiatry

Key finding: Smoking, high body-mass index and high fasting plasma glucose levels were main risk factors. +4 more findings

• Risk Factors

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Stacked CNN-based multichannel attention networks for Alzheimer disease detection

48/100 ✓ Peer-reviewed Brain scans and imaging Scientific Reports

Key finding: The proposed model's high performance surpassed state-of-the-art (SOTA) models and proved its excellence as a significant advancement in AD classification using MRI images.

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Exercise, the Gut Microbiome and Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms

49/100 ✓ Peer-reviewed Prevention and risk Gastroenterology

Key finding: In contrast, and despite the large interindividual variation in the human gut microbiome, reduced microbial diversity has been implicated in several diseases of the gastrointestinal (GI) tract, systemic immune diseases, and cancers. +4 more findings

• Treatments
• Lifestyle

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Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance

58/100 ✓ Peer-reviewed Tau biomarkers Annals of clinical and translational neurology

Key finding: However, a recent systematic review and meta-analysis did not support differences in orexin-A between AD and controls. +3 more findings

• Biomarkers

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Temporal Dynamics and Biological Variability of Alzheimer Biomarkers

65/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Among the plasma biomarkers, phosphorylated tau (p-tau) 217 exhibited the highest concordance rate with Aβ (2326 of 2571 [90.5%]) and tau (100 of 120 [83.3%]) PET. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Cost-utility of a new psychosocial goal-setting and manualised support intervention for independence in dementia (NIDUS-Family) versus goal setting and routine care: an economic evaluation embedded within a randomised controlled trial

68/100 ✓ Peer-reviewed Costs and economics The Lancet Healthy Longevity

Key finding: Between April 30, 2020, and May 9, 2022, we randomly allocated 204 participants (109 [53%] women and 95 [47%] men) to the intervention group and 98 (60 [61%] women and 38 [39%] men) to the control group. 218 (72%) participants at 6 months and 178 (59%) at 12 months provided cost data. +1 more finding

• Clinical Trials
• Policy
• Caregiving

Full summary, score breakdown and related studies → Original source

White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease

50/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

Key finding: We assessed the severity of amyloid-β accumulation and white matter lesions (WML) in the brain, and their association with cognitive decline, in patients (n = 47) with Alzheimer's disease (AD). +3 more findings

• Brain Scans

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Validation of a novel neuroimaging signature for dementia and clinical Alzheimer's disease in the population-based Rotterdam study

46/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer s Disease

Key finding: How these findings translate to other populations, remains undetermined.

• Brain Scans

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Prevalence and correlates of the head turning sign in mild cognitive impairment and dementia due to neurodegenerative, chronic cerebrovascular, and mixed etiologies

45/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease

Key finding: In patients with cognitive impairment due to diverse causes, the HTS might occur regardless of MCI versus dementia status and across different etiologies. +3 more findings

• Diagnosis
• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Overlap in the diagnostic criteria of frontotemporal dementia syndromes with parkinsonism

46/100 ✓ Peer-reviewed Lewy body dementia Journal of Alzheimer s Disease

Key finding: Higher cerebrospinal fluid levels of phosphorylated tau and tau were observed in the bvFTD group compared to PSP (p = 0.009, p = 0.002). +1 more finding

• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cultural variation in trust and acceptability of artificial intelligence diagnostics for dementia

34/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer s Disease

Key finding: Qualitative feedback from a diverse public engagement group indicated that cultural variations in trust and acceptability of AI diagnostics may be an unrecognised source of real-world inequity.

• Digital Tools

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Increased risk of dementia associated with herpes simplex virus infections: Evidence from a retrospective cohort study using U.S. electronic health records

51/100 ✓ Peer-reviewed How common it is Journal of Alzheimer s Disease

Key finding: There was a significant difference in dementia incidence in the HSV-infected group versus the control. +3 more findings

• Risk Factors

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Uncovering nutrition needs in dyads of caregivers and persons with dementia

37/100 ✓ Peer-reviewed Caregiving Journal of Alzheimer s Disease

Key finding: Nutrition risk was more common among caregivers when PWD demonstrated nutrition risk. +4 more findings

• Caregiving
• Lifestyle

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Gay Men as Caregivers for Spouses with Dementia: Intersections of Gender and Sexual Orientation

42/100 ✓ Peer-reviewed Caregiving The Journals of Gerontology Series B

Key finding: We find that sexual minority status and gender interact to shape gay men's caregiving approaches. +4 more findings

• Caregiving

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Ambient Air Pollution and Parkinson's Disease and Alzheimer's Disease: An Updated Meta-Analysis

71/100 ✓ Peer-reviewed Risk factors Toxics

Key finding: In total, 42 eligible studies were included. +4 more findings

• Risk Factors

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Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease

45/100 ✓ Peer-reviewed Disease mechanisms Acta Neuropathologica Communications

Key finding: Using the RGC marker ribonucleic acid binding protein with multiple splicing (RBPMS) and Nissl staining, we found a 46–56% reduction in RBPMS + RGCs and Nissl + neurons in the ganglion cell layer (GCL) of MCI and AD retinas ( P < 0.05–0.001). +4 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

From Big Data to the Clinic: Methodological and Statistical Enhancements to Implement the UK Biobank Imaging Framework in a Memory Clinic

47/100 ✓ Peer-reviewed Long-term cohort studies Human Brain Mapping

Key finding: We explored associations between resultant imaging-derived phenotypes (IDPs) and clinical phenotypes in the OBHC patient population (N = 213), applying hierarchical FDR correction to account for multiple testing. 14%-24% of scans were flagged by automated QC tools, but upon visual inspection, only 0%-2.4% of outputs were excluded. +4 more findings

• Brain Scans
• Care Services

Full summary, score breakdown and related studies → Original source

Diversity in United States Dementia Prevention Trials: An Updated Systematic Review of Eligibility Criteria and Recruitment Strategies

51/100 ✓ Peer-reviewed Health systems and care delivery Dementia and geriatric cognitive disorders

Key finding: Analyses demonstrated that criteria regarding cardiovascular disease, pulmonary disease, hearing impairment, and sedentary lifestyle were associated with relatively high participant diversity, while gastro-intestinal/liver disease, motivation to participate, and language proficiency criteria were associated with relatively little diversity. +3 more findings

• Prevention
• Health Equity

Full summary, score breakdown and related studies → Original source