Newest studies

Empowering Family Care Partners to Optimize Delirium Care for Persons Living With Dementia

29/100 ✓ Peer-reviewed Clinical safety Research in Gerontological Nursing

Key finding: The study highlights the significant role FCPs play in DSD care and the urgent need for interventions that address their educational and emotional needs to improve patient and caregiver well-being. [ Research in Gerontological Nursing, 18 (3), 113–123.] +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

Influence of Ibuprofen on glycerophospholipids and sphingolipids in context of Alzheimer´s Disease

35/100 ✓ Peer-reviewed Inflammation and the immune system Biomedicine & Pharmacotherapy

Key finding: Alzheimer's disease (AD) is a multifactorial disorder associated with neuroinflammation, elevated oxidative stress, lipid alterations as well as amyloid-deposits and the formation of neurofibrillary tangles. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Determination of balance, fall risk, and kinesiophobia in individuals with Alzheimer’s Dementia

38/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Psychology

Key finding: It was found that individuals with Alzheimer’s disease (AD) have poorer balance and a higher risk of falls compared to healthy individuals. +2 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model

41/100 ✓ Peer-reviewed Lewy body dementia Brain Behavior and Immunity

Key finding: Previous results from our laboratory showed a TAU P301L -dependent increase in CB 2 receptor expression in hippocampal neurons of a FTD mouse model, alongside the neuroprotective impact of CB 2 ablation. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia

40/100 ✓ Peer-reviewed Lewy body dementia Cells

Key finding: Recent investigations have illuminated the significant role of sEVs in the pathogenesis of vascular dementia.

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Autoimmune thyroid disease is a risk factor for mood disorders, a Mendelian randomization study

39/100 ✓ Peer-reviewed Risk factors Journal of Affective Disorders

Key finding: Gene-proxy for Graves' disease was associated with an increased risk of major depressive disorder (P-value = 0.02), whereas gene-proxy for autoimmune thyroiditis was linked to a greater risk of bipolar disorder (P-value = 0.043). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Improving Respite Outcomes for Caregivers: Who Benefits and Under What Conditions?

42/100 ✓ Peer-reviewed Caregiving Journal of Applied Gerontology

Key finding: Alzheimer’s disease and related dementias (ADRD) pose a substantial caregiving burden in the United States, yet efforts to improve caregiver well-being have seen mixed results. +2 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Implementation of Telemedicine for Patients With Dementia and Their Caregivers: Scoping Review

61/100 ✓ Peer-reviewed Caregiving Journal of Medical Internet Research

Key finding: This study included 54 articles, comprising 14,446 participants from 10 countries. +4 more findings

• Clinical Trials
• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Mayo Normative Studies: Regression-based normative data for remote self-administration of the Stricker Learning Span, Symbols Test, and Mayo Test Drive Screening Battery Composite and validation in individuals with mild cognitive impairment and dementia

50/100 ✓ Peer-reviewed Getting a diagnosis The Clinical Neuropsychologist

Key finding: No model terms met the a priori cut-off beyond the base model, including device type, response input source (e.g. mouse, etc.), or session interference. +4 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

A practical overview of the use of amyloid-PET Centiloid values in clinical trials and research

43/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage. Clinical

Key finding: The introduction of Centiloids in 2015 allowed for the transformation of amyloid-PET quantitative data to a common scale, enhancing comparability across studies and potentially enabling pooled analysis. +4 more findings

• Brain Scans
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Associations Between Stroke Type, Ischemic Stroke Subtypes, and Poststroke Cognitive Trajectories

59/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: We identified 1143 dementia-free individuals with acute stroke during follow-up: 1061 (92.8%) ischemic, 82 (7.2%) hemorrhagic, 49.9% female, and 30.8% Black. +4 more findings

Full summary, score breakdown and related studies → Original source

Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease Research

37/100 ✓ Peer-reviewed Disease mechanisms Physiological Research

Key finding: The TgF344-AD rat model offers significant potential in identifying biomarkers for early detection and therapeutic interventions, providing a robust platform for advancing translational AD research.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

UK Biobank data demonstrate long-term exposure to floods is a risk factor for incident dementia

46/100 ✓ Peer-reviewed Long-term cohort studies Communications Medicine

Key finding: In the fully adjusted model, the cumulative odds ratios (OR) are 1.28 (95% confidence interval [CI]: 1.25–1.31) for any dementia, 1.44 (95% CI: 1.36–1.53) for Alzheimer’s disease and 1.65 (95% CI: 1.48–1.83) for vascular dementia, associated with per unit increase in annual cumulative flooding exposure over lag 0–6 years. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort

41/100 ✓ Peer-reviewed Long-term cohort studies Environmental Health Perspectives

Key finding: , respectively. standards in late life. https://doi.org/10.1289/EHP14723.

Full summary, score breakdown and related studies → Original source

Epidemiology and risk factors of fungal pathogens in sepsis: a prospective nationwide multicenter cohort study

53/100 ✓ Peer-reviewed Risk factors BMC Infectious Diseases

Key finding: Of the 11,981 patients with sepsis, fungal pathogens were identified in 3.4% of cases. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Barriers and enablers to stakeholder engagement in the co-creation of disaster risk reduction solutions

45/100 ✓ Peer-reviewed Prevention and risk International Journal of Disaster Risk Reduction

Key finding: The results indicate that a first crucial but challenging step for a successful co-creation process is to increase stakeholder interest and motivation to participate, to raise awareness on the topic of risk and DRR by combining different tools, methods, as well as local and scientific knowledge.

• Prevention

Full summary, score breakdown and related studies → Original source

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

57/100 ✓ Peer-reviewed Prevention and risk Signal transduction and targeted therapy

Key finding: Ageing is the primary risk factor for neurodegenerative diseases and their associated comorbidities, such as vascular pathologies, in elderly individuals. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases

70/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: We analyzed 1,240 MRIs from 473 patients (age: 69.2 ± 7.4 [range: 49-87]; 32.8% women). +1 more finding

• Biomarkers
• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Opposite causal effects of type 2 diabetes and metformin on Alzheimer's disease

61/100 ✓ Peer-reviewed Drug development The journal of prevention of Alzheimer's disease

Key finding: Our two-sample MR analysis indicated that T2D is not associated with the risk of AD (OR: 1.03, CI: 0.99-1.08, P = 0.128). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Multi-Ancestry Transcriptome-Wide Association Studies of Cognitive Function, White Matter Hyperintensity, and Alzheimer’s Disease

43/100 ✓ Peer-reviewed Vascular contributions International Journal of Molecular Sciences

Key finding: Using the joint likelihood-based inference framework in Multi-ancEstry TRanscriptOme-wide analysis (METRO), we leveraged gene expression data from European ancestry (EA) and African ancestry (AA) samples to identify genes associated with general cognitive function, white matter hyperintensity (WMH), and AD. +3 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Delirium management in 2024: A status check and evolution in clinical practice since 2016

45/100 ✓ Peer-reviewed Clinical safety Intensive and Critical Care Nursing

Key finding: Participating ICU in both surveys (2016: n = 559, 2024: n = 447) had similar basic characteristics and enabled comparison. +4 more findings

Full summary, score breakdown and related studies → Original source

Alkaloids from Caliphruria subedentata (Amaryllidaceae) as Regulators of AChE, BuChE, NMDA and GSK3 Activity: An In Vitro and In Silico Approach for Mimicking Alzheimer´s Disease

38/100 ✓ Peer-reviewed Disease mechanisms Neurochemical Research

Key finding: Patients with Alzheimer's disease (AD) have two types of abnormal protein buildups: amyloid plaques and neurofibrillary tangles, in addition to the early synaptic dysfunction associated with the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence

44/100 ✓ Peer-reviewed Brain tissue and pathology Acta Neuropathologica Communications

Key finding: Our findings reveal progressive degenerative mechanisms in motor neurons expressing endogenous Tdp-43∆NLS mutant, independent of Tdp-43 overexpression or other confounding factors. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Apathy in Dementia: A Pilot Study Providing Insights from Neuropsychiatric and Radiological Perspectives

47/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Clinical Medicine

Key finding: Apathy was significantly more prevalent in dementia and MCI patients compared to HC. +4 more findings

Full summary, score breakdown and related studies → Original source

Comparison of Deep Learning and Traditional Machine Learning Models for Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers

48/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Molecular Sciences

Key finding: Based on grid search, the DNN model with an activation function of “Rectifier With Dropout” with 2 layers and 32 of 35 selected proteomic biomarkers revealed the best model with the highest accuracy of 0.995 and an F1 Score of 0.996, while among seven traditional ML methods, XGBoost was the best with an accuracy of 0.986 and an F1 Score of 0.985. +2 more findings

• Digital Tools
• Early Stage
• Biomarkers

Full summary, score breakdown and related studies → Original source