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Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence
Enzo Pereira de Lima, Lucas Fornari Laurindo, Vitor Cavallari Strozze Catharin, Rosa Direito, Masaru Tanaka, Íris Jasmin Santos German, Caroline Barbalho Lamas, Élen Landgraf Guiguer et al.. Metabolites, 2025-02-13
Topic: Brain proteins, microglia and lab models
They remain a significant focus of scientific and clinical interest due to their increasing medical and social importance. In summary, they show that the use of these compounds is related to significant improvements in cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, and mood disorders.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
de Lima, E. P., Laurindo, L. F., Catharin, V. C. S., Direito, R., Tanaka, M., German, Í. J. S., et al. (2025). Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence. Metabolites. https://doi.org/10.3390/metabo15020124
Vancouver
de Lima EP, Laurindo LF, Catharin VCS, Direito R, Tanaka M, German ÍJS, et al. Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence. Metabolites. 2025. doi:10.3390/metabo15020124. PMID: 39997749.
BibTeX
@article{delima2025-39997749,
author = {de Lima, Enzo Pereira and Laurindo, Lucas Fornari and Catharin, Vitor Cavallari Strozze and Direito, Rosa and Tanaka, Masaru and German, Íris Jasmin Santos and Lamas, Caroline Barbalho and Guiguer, Élen Landgraf and others},
title = {{Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence}},
journal = {Metabolites},
year = {2025},
doi = {10.3390/metabo15020124},
pmid = {39997749},
url = {https://doi.org/10.3390/metabo15020124}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- They remain a significant focus of scientific and clinical interest due to their increasing medical and social importance.
- In summary, they show that the use of these compounds is related to significant improvements in cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, and mood disorders.
Why it matters
This review reports that use of polyphenols, alkaloids, and terpenoids is related to improvements in cognition, memory, and several behavioral symptoms. It is a review of existing evidence and does not establish these compounds as proven treatments for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Metabolites) |
| Journal's citation record | 1 / 4 | Metabolites: journal h-index 117 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 94 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 31.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 6 / 6 | Cited 99.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 94 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Sandra Maria Barbalho: h-index 46 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Universidade de São Paulo: institution h-index 936 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39997749) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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