Newest studies

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

53/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica

Key finding: Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukodystrophy, Nasu-Hakola disease (NHD). +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

CSF alpha-synuclein aggregates by seed amplification and clinical presentation of AD

64/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: CSF was αSyn-SAA positive (αSyn+) in 36/80 AD patients (45%) and in 2/28 controls (7.1%). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Air pollution is associated with faster cognitive decline in Alzheimer's disease

66/100 ✓ Peer-reviewed Risk factors Annals of clinical and translational neurology

Key finding: Higher chronic exposure to SO2 was associated with a faster decline in memory score, whereas chronic exposure to CO, NO2 , and PM10 were not associated with the rate of cognitive decline. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Tau-PET imaging in Parkinson's disease: a systematic review and meta-analysis

79/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in neurology

Key finding: A total of 15 eligible studies were included in the meta-analysis. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Higher plasma β-synuclein indicates early synaptic degeneration in Alzheimer's disease

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma β-synuclein levels were higher in preclinical AD and even higher in MCI and AD dementia. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies

55/100 ✓ Peer-reviewed Biomarkers Nature aging

Key finding: Our results indicate that p-tau217, p-tau231 and p-tau205 are the plasma tau forms that best reflect AD-related brain changes, although with distinct emergences along the disease course and correlations with AD features-amyloid and tau. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Diversity of Studies on Neighborhood Greenspace and Brain Health by Racialized/Ethnic Group and Geographic Region: A Rapid Review

49/100 ✓ Peer-reviewed Risk factors International Journal of Environmental Research and Public Health

Key finding: This is a significant gap given the known disparities in both greenspace access and ADRD risk between racialized/ethnic groups and between developed versus developing countries.

• Health Equity

Full summary, score breakdown and related studies → Original source

Educational Attainment and Dementia: Mediation by Mid-Life Vascular Risk Factors

66/100 ✓ Peer-reviewed Prevention and risk Annals of Neurology

Key finding: A substantial proportion of the relationship between education and dementia was mediated through mid-life vascular risk factors. +1 more finding

• Risk Factors
• Prevention
• Genetics

Full summary, score breakdown and related studies → Original source

Amyloid β-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype

41/100 ✓ Peer-reviewed Genetics eNeuro

Key finding: The apolipoprotein E gene (APOE) confers the greatest genetic risk factor for Alzheimer's disease (AD), wherein the ε4 allele confers an elevated risk compared with the ε3 allele. +2 more findings

• Genetics
• Brain Biology
• Policy

Full summary, score breakdown and related studies → Original source

Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records

55/100 ✓ Peer-reviewed Digital health tools The Lancet. Public health

Key finding: We comprehensively estimated the risk of multiple morbidity across the lifespan in people with Down syndrome compared with the general population and controls with other forms of intellectual disability. +3 more findings

• Down Syndrome
• Risk Factors

Full summary, score breakdown and related studies → Original source

Associations of blood cell indices and anemia with risk of incident dementia: A prospective cohort study of 313,448 participants

64/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Low hemoglobin and anemia are associated with cognitive impairment and Alzheimer's disease (AD). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice

51/100 ✓ Peer-reviewed TREM2 and immune genetics Science translational medicine

Key finding: Considering the crucial role of immunomodulating genes such as that encoding the triggering receptor expressed on myeloid cells type 2 (TREM2) in removing pathogenic amyloid-β (Aβ) plaques and regulating neurodegeneration in the brain, our aim was to investigate whether and how sleep loss influences microglial function in mice. +3 more findings

• Brain Biology
• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

Diagnostic performance of plasma Aβ 1-42 , Aβ 1-40 and pTau 181 in the LUMIPULSE automated platform for the detection of Alzheimer disease

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's medRxiv

Key finding: Recently-developed blood markers for Alzheimer’s (AD) detection have high accuracy but usually require ultra-sensitive analytic tools not commonly available in clinical laboratories. +3 more findings

• Biomarkers

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease

57/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica communications

Key finding: We performed a genome-wide association study on the largest collection of amyloid imaging data (N = 13,409) to date, across multiple ethnicities from multicenter cohorts to identify variants associated with brain amyloidosis and AD risk. +3 more findings

• Genetics
• Brain Scans
• Health Equity

Full summary, score breakdown and related studies → Original source

The association between personality and plasma biomarkers of astrogliosis and neuronal injury

66/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: Personality traits have been associated with the risk of dementia and Alzheimer's disease neuropathology, including amyloid and tau. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Mitochondria: It is all about energy

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in physiology

Key finding: This review focuses on understanding the mitochondrial mechanisms of action that allow for the maintenance of mitochondrial health and the pathways toward dysregulated mechanisms. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Cognitive Function and its Decline: A Prospective Study and Meta-analysis of Cohort Studies

78/100 ✓ Peer-reviewed Prevention trials The American journal of clinical nutrition

Key finding: Our findings suggest that higher adherence to the MIND diet was associated with better cognitive function and potentially slower cognitive decline in later life. +3 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

47/100 ✓ Peer-reviewed Disease mechanisms Nature communications

Key finding: We previously demonstrated that soluble pathogenic forms of tau (tau oligomers) accumulate in brain microvasculature of AD and other tauopathies, including prominently in microvascular endothelial cells. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Does the Area Deprivation Index (ADI) influence dementia evaluation and diagnosis in Virginia? (S29.004)

41/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: 14,292 patients were diagnosed with dementia over 2018–2021 (age 76.5+/−10.3 years; 53.1% female), with 96.3% linked to a census-tract-level ADI. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Fusing the Virtual and Physical Worlds to Identify Declines in Instrumental Activities of Daily Living Associated with Parkinson’s Disease (S37.008)

31/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Motor and cognitive performance differed across PD and control groups. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

CSF neurochemical profile and cognitive changes in Parkinson's disease with mild cognitive impairment

64/100 ✓ Peer-reviewed Biomarkers NPJ Parkinson's disease

Key finding: Among all biomarkers considered, only NfL/p-NfH ratio was significantly higher in PD-MCI vs. +1 more finding

• Biomarkers
• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience

61/100 ✓ Peer-reviewed Inflammation and the immune system Nature neuroscience

Key finding: Here, we report that activation of cyclic GMP-AMP synthase (cGAS) diminishes cognitive resilience by decreasing the neuronal transcriptional network of myocyte enhancer factor 2c (MEF2C) through type I interferon (IFN-I) signaling. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial

71/100 ✓ Peer-reviewed Genetics Nature Medicine

Key finding: Tau plays a key role in Alzheimer's disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology.

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

56/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: Overall, our results provide insights into the transcriptional diversity resulting from AD genetic architecture and cellular heterogeneity.

• Genetics

Full summary, score breakdown and related studies → Original source

Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum

57/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Our findings suggest that the informant report is particularly relevant in patients with MCI where it strongly relates to higher amyloid-PET, indicative of impairment due to AD. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source